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Aziz sancar
 Lindur m谷: 8 Shtator,1946 n谷 Savur, Turqi.
 sht谷 nj谷 nga tet谷 femij谷t e familjes Sancar dhe I martuar me Gwen
Sancar. S谷 bashku kan谷 themeluar Carolina T端rk Evi.
 Shkoll谷n fillore e kreu n谷 Savur, aty ku lindi.
 Studimet I kreu n谷 Universitetin e Stambollit.(1969)
 Vazhimet me tej I kreu n谷 Universitetin e Teksasit, n谷 Dallas, n谷
laboratorin e Dr. C. Stan Rupert.(1977)
 Tani Aziz Sancar punon n谷 Universtietin Mjeksis谷 n谷 New York dhe n谷
Shkollen e Mjeksis谷 n谷 Yales.
 Biokimi.
 Biologji Molekulare.
 Biofizik谷 molekulare.
 Riparimi i ADN.
 K谷rkime mbi kancerin(s谷mundjet malinje).
 sht谷 nominuar p谷r 巽mimin Presidential Young
Investigator nga National Science Foundation n谷
Biofizik谷 molekulare n谷 1984.
 TB聴TAK-mim shkencor (1995)
 mimi -Vehbi Ko巽 (2007)
 mimi NOBEL n谷 Kimi (2015)
 mimi ASBMB Vallee (2016)
 Mahnitja e Aziz Sancar me jet谷n e molekulave filloi gjate koh谷s q谷 ai po
studionte p谷r diplom谷n e tij mjek谷sore n谷 Stamboll.Pas diplomimit ai punoi
si mjek dhe m谷 pas ai studioi p谷r biokimi. Interesi i tij u t谷rhoq nga nj谷
fenomen n谷 m谷nyr谷 t谷 ve巽ant谷: kur bakteret jan谷 t谷 ekspozuar ndaj doza
vdekjeprur谷se e rrezatimit UV, ato papritmas mund t谷 sh谷rohen n谷 qoft谷 se
ata jan谷 t谷 ndri巽uar me drit谷 t谷 dukshme blu . SANCAR ishte kurioz p谷r
k谷t谷 ngjarje thuajse magjike; si funksiononte ajo kimikisht?
 Claud Rupert kishte studiuar k谷t谷 fenomen dhe Aziz SANCAR u bashkua n谷
laboratorin e tij n谷 Universitetin e Teksasit n谷 Dallas. Ne 1976 me mjetet e
asaj kohe p谷r Biologjin谷 molekulare, ai arriti te klonoj谷 gjenin, p谷r enzim谷n
e cila riparon d谷mtimin e b谷r谷 nga rrezet UV,(Photolyase) dhe gjithashtu
b谷ri q谷 bakteria t谷 mbi-prodhoj谷 enzim谷. Por kjo nuk u mir谷prit dhe shum谷
her谷 u kund谷rshtua nga t谷 tjer谷t, k谷shtu q谷 SANCAR e braaktisi Photolyase
dhe u pun谷sua si teknik laboratori n谷 Shkoll谷n Mjek谷sore YALE, ku aty do
t谷 vazhdote pun谷n e tij mbi riparimin e ADN-s谷. Dhe k谷tu filloi puna e tij e
cila do ta drejtonte drejt fitimit t谷 巽mimit NOBEL n谷 KIMI.
 Deri at谷her谷 ishte e qart谷 se bakteret kishin dy sisteme p谷r riparimin
e d谷mit nga rrezet UV: P谷rve巽 photolyase, u zbulua nj谷 sistem i dyt谷
q谷 funksiononte n谷 err谷sir谷. Koleg谷t e Sancar n谷 YALE e kishin
studiuar k谷t谷 fenomen q谷 n谷 1960 duke p谷rdorur tre shtame t谷
bakterieve t谷 ndjeshme nga rrezet UV dhe u realizuan tre mutacione
t谷 ndryshme gjenetike: uvrA, uvrB dhe uvrC.
 Sancar vazhdoi studimin e tij dhe n谷 shum谷 pak vjet ai arriti t谷
identifikoj, izoloj谷 dhe karakterizoj enzimat e koduara nga gjenet
uvrA, uvrB dhe uvrC. N谷 terrenin In Vitro ai tregoi se k谷to enzima
mund t谷 identifikonin d谷mtimin e b谷r谷 nga rrezet UV dhe pastaj
b谷nte dy prerje t谷 extremiteteve t谷 ADN, pra n谷 dy an谷t e pjes谷ve t谷
d谷mtuara. Nj谷 fragment prej 12-13 nukleotidesh duke p谷rfshir谷 k谷tu
dhe pjes谷n e d谷mtuar do t谷 hiqej.
Aziz sancar
 Njohurit谷 q谷 Aziz Sancar dispononte p谷r detajet e proceseve molekulare
ndryshuan t谷r谷sin谷 e fushave t谷 k谷rkimit. N谷 1983 ai i publikoi ato. M谷
von谷, paralelisht me Tomas Lidahl ai punoi p谷r ti perfkesionuar fazat e
m谷tejshme t谷 riparimit. Punoi fort p谷r ti v谷n谷 n谷 zbatim edhe n谷 njer谷z.
 Rezultoi se n谷 njer谷z proceset jan谷 m谷 komplekse sesa te bakteriet, por n谷
terma kimike le t谷 themi q谷 riparimi i d谷mtimit te ADN-s谷 nga rrezatimi
UV n谷 vija t谷 p谷rgjithshme 谷sht谷 nj谷soj tek t谷 gjitha organzmat.
 Interesi fillestar i Sancar p谷r enzim谷n photolyase nuk u la me aq.Iu
rikthye p谷rs谷ri zbulimit t谷 mekanizmit p谷rgjegj谷s p谷r ringjalljen e bakterit.
 Aziz Sancar gjithashtu ndihmoi p谷r t谷 treguar se nj谷 ekuialent i njeriut p谷r
photolyases na ndihmon p谷r t谷 vendosur or谷n cirkadiane.
 Riparimi i prerjes s谷 nukleotideve 谷sht谷 nj谷 mekaniz谷m riparimi i ADN-
s谷. ADN-ja d谷mtohet si rezultat i kimikateve dhe rrezatimeve t谷
ndryshme. Ekzistojn谷 tre rrug谷 riparimi:
1. NER-riparimi I prerjes s谷 nukleotideve.
2. BER-riparimi I prerjes baz谷.
3. MMR-riparimi i mosp谷rputhjes s谷 ADN-s谷.
NER heq d谷me t谷 ADN-s谷 t谷 shkaktuara nga rrezatimi UV. Kryesisht
d谷mtohen dimeret eTimin谷s dhe 6,4 photoproducts. Njohja e d谷mit
巽on n谷 heqjen e segmentit t谷 ADN-s谷 q谷 ka plag谷n. Mbetet ADN-ja e
pad谷mtuar dhe ADN polimeraza e p谷rdor at谷 si shabllon p谷r t谷
sintetizuar nj谷 rend t谷 shkurt谷r plot谷sues. NER mund t谷 kryhet n谷 dy
rrug谷
1.NER globale gjenomike(GG-NER)
2.NER 巽iftit transkpriptues(TC-NER)
K谷to dy rrug谷 ndryshojn谷 vet谷m n谷 m谷nyren sesi e njohin d谷min e ADN-
s谷, por kan谷 t谷 nj谷jtin proces p谷rsa i p谷rket prerjes s谷 plag谷s dhe
riparimit.
Aziz sancar
Aziz sancar
 Q谷llimi i k谷tij projekti p谷rkon po ashtu dhe me
r谷nd谷sin谷 e tij.T谷 njiheshim me figur谷n e njohur
t谷 Biologjis谷 Molekulare Aziz Sancar dhe
veprimtarin谷 e tij.
 el谷si i suksesit t谷 tij p谷r t谷 fituar NOBEL n谷
Kimi ishte puna e pandalur dhe besimi q谷 kishte
n谷 vetveten e tij pavar谷sisht kund谷rshtimeve t谷
shumta. Puna e tij rezultoi si p谷rfitim p谷r t谷
gjitha k谷rkimet shkencore por mbi t谷 gjitha p谷r
shoq谷rin谷 humane.Tashm谷 谷sht谷 b谷r谷 m谷 e
leht谷 p谷r ti b谷r谷 ball谷 s谷mundjeve malinje.
 https://en.wikipedia.org/wiki/Aziz_Sancar
 https://en.wikipedia.org/wiki/Nucleotide_excisio
n_repair
 http://www.med.unc.edu/biochem/people/facult
y/primary/asancar
 http://www.nobelprize.org/nobel_prizes/chemist
ry/laureates/2015/popular-
chemistryprize2015.pdf
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Aziz sancar

  • 2. Lindur m谷: 8 Shtator,1946 n谷 Savur, Turqi. sht谷 nj谷 nga tet谷 femij谷t e familjes Sancar dhe I martuar me Gwen Sancar. S谷 bashku kan谷 themeluar Carolina T端rk Evi. Shkoll谷n fillore e kreu n谷 Savur, aty ku lindi. Studimet I kreu n谷 Universitetin e Stambollit.(1969) Vazhimet me tej I kreu n谷 Universitetin e Teksasit, n谷 Dallas, n谷 laboratorin e Dr. C. Stan Rupert.(1977) Tani Aziz Sancar punon n谷 Universtietin Mjeksis谷 n谷 New York dhe n谷 Shkollen e Mjeksis谷 n谷 Yales.
  • 3. Biokimi. Biologji Molekulare. Biofizik谷 molekulare. Riparimi i ADN. K谷rkime mbi kancerin(s谷mundjet malinje).
  • 4. sht谷 nominuar p谷r 巽mimin Presidential Young Investigator nga National Science Foundation n谷 Biofizik谷 molekulare n谷 1984. TB聴TAK-mim shkencor (1995) mimi -Vehbi Ko巽 (2007) mimi NOBEL n谷 Kimi (2015) mimi ASBMB Vallee (2016)
  • 5. Mahnitja e Aziz Sancar me jet谷n e molekulave filloi gjate koh谷s q谷 ai po studionte p谷r diplom谷n e tij mjek谷sore n谷 Stamboll.Pas diplomimit ai punoi si mjek dhe m谷 pas ai studioi p谷r biokimi. Interesi i tij u t谷rhoq nga nj谷 fenomen n谷 m谷nyr谷 t谷 ve巽ant谷: kur bakteret jan谷 t谷 ekspozuar ndaj doza vdekjeprur谷se e rrezatimit UV, ato papritmas mund t谷 sh谷rohen n谷 qoft谷 se ata jan谷 t谷 ndri巽uar me drit谷 t谷 dukshme blu . SANCAR ishte kurioz p谷r k谷t谷 ngjarje thuajse magjike; si funksiononte ajo kimikisht? Claud Rupert kishte studiuar k谷t谷 fenomen dhe Aziz SANCAR u bashkua n谷 laboratorin e tij n谷 Universitetin e Teksasit n谷 Dallas. Ne 1976 me mjetet e asaj kohe p谷r Biologjin谷 molekulare, ai arriti te klonoj谷 gjenin, p谷r enzim谷n e cila riparon d谷mtimin e b谷r谷 nga rrezet UV,(Photolyase) dhe gjithashtu b谷ri q谷 bakteria t谷 mbi-prodhoj谷 enzim谷. Por kjo nuk u mir谷prit dhe shum谷 her谷 u kund谷rshtua nga t谷 tjer谷t, k谷shtu q谷 SANCAR e braaktisi Photolyase dhe u pun谷sua si teknik laboratori n谷 Shkoll谷n Mjek谷sore YALE, ku aty do t谷 vazhdote pun谷n e tij mbi riparimin e ADN-s谷. Dhe k谷tu filloi puna e tij e cila do ta drejtonte drejt fitimit t谷 巽mimit NOBEL n谷 KIMI.
  • 6. Deri at谷her谷 ishte e qart谷 se bakteret kishin dy sisteme p谷r riparimin e d谷mit nga rrezet UV: P谷rve巽 photolyase, u zbulua nj谷 sistem i dyt谷 q谷 funksiononte n谷 err谷sir谷. Koleg谷t e Sancar n谷 YALE e kishin studiuar k谷t谷 fenomen q谷 n谷 1960 duke p谷rdorur tre shtame t谷 bakterieve t谷 ndjeshme nga rrezet UV dhe u realizuan tre mutacione t谷 ndryshme gjenetike: uvrA, uvrB dhe uvrC. Sancar vazhdoi studimin e tij dhe n谷 shum谷 pak vjet ai arriti t谷 identifikoj, izoloj谷 dhe karakterizoj enzimat e koduara nga gjenet uvrA, uvrB dhe uvrC. N谷 terrenin In Vitro ai tregoi se k谷to enzima mund t谷 identifikonin d谷mtimin e b谷r谷 nga rrezet UV dhe pastaj b谷nte dy prerje t谷 extremiteteve t谷 ADN, pra n谷 dy an谷t e pjes谷ve t谷 d谷mtuara. Nj谷 fragment prej 12-13 nukleotidesh duke p谷rfshir谷 k谷tu dhe pjes谷n e d谷mtuar do t谷 hiqej.
  • 8. Njohurit谷 q谷 Aziz Sancar dispononte p谷r detajet e proceseve molekulare ndryshuan t谷r谷sin谷 e fushave t谷 k谷rkimit. N谷 1983 ai i publikoi ato. M谷 von谷, paralelisht me Tomas Lidahl ai punoi p谷r ti perfkesionuar fazat e m谷tejshme t谷 riparimit. Punoi fort p谷r ti v谷n谷 n谷 zbatim edhe n谷 njer谷z. Rezultoi se n谷 njer谷z proceset jan谷 m谷 komplekse sesa te bakteriet, por n谷 terma kimike le t谷 themi q谷 riparimi i d谷mtimit te ADN-s谷 nga rrezatimi UV n谷 vija t谷 p谷rgjithshme 谷sht谷 nj谷soj tek t谷 gjitha organzmat. Interesi fillestar i Sancar p谷r enzim谷n photolyase nuk u la me aq.Iu rikthye p谷rs谷ri zbulimit t谷 mekanizmit p谷rgjegj谷s p谷r ringjalljen e bakterit. Aziz Sancar gjithashtu ndihmoi p谷r t谷 treguar se nj谷 ekuialent i njeriut p谷r photolyases na ndihmon p谷r t谷 vendosur or谷n cirkadiane.
  • 9. Riparimi i prerjes s谷 nukleotideve 谷sht谷 nj谷 mekaniz谷m riparimi i ADN- s谷. ADN-ja d谷mtohet si rezultat i kimikateve dhe rrezatimeve t谷 ndryshme. Ekzistojn谷 tre rrug谷 riparimi: 1. NER-riparimi I prerjes s谷 nukleotideve. 2. BER-riparimi I prerjes baz谷. 3. MMR-riparimi i mosp谷rputhjes s谷 ADN-s谷. NER heq d谷me t谷 ADN-s谷 t谷 shkaktuara nga rrezatimi UV. Kryesisht d谷mtohen dimeret eTimin谷s dhe 6,4 photoproducts. Njohja e d谷mit 巽on n谷 heqjen e segmentit t谷 ADN-s谷 q谷 ka plag谷n. Mbetet ADN-ja e pad谷mtuar dhe ADN polimeraza e p谷rdor at谷 si shabllon p谷r t谷 sintetizuar nj谷 rend t谷 shkurt谷r plot谷sues. NER mund t谷 kryhet n谷 dy rrug谷 1.NER globale gjenomike(GG-NER) 2.NER 巽iftit transkpriptues(TC-NER) K谷to dy rrug谷 ndryshojn谷 vet谷m n谷 m谷nyren sesi e njohin d谷min e ADN- s谷, por kan谷 t谷 nj谷jtin proces p谷rsa i p谷rket prerjes s谷 plag谷s dhe riparimit.
  • 12. Q谷llimi i k谷tij projekti p谷rkon po ashtu dhe me r谷nd谷sin谷 e tij.T谷 njiheshim me figur谷n e njohur t谷 Biologjis谷 Molekulare Aziz Sancar dhe veprimtarin谷 e tij. el谷si i suksesit t谷 tij p谷r t谷 fituar NOBEL n谷 Kimi ishte puna e pandalur dhe besimi q谷 kishte n谷 vetveten e tij pavar谷sisht kund谷rshtimeve t谷 shumta. Puna e tij rezultoi si p谷rfitim p谷r t谷 gjitha k谷rkimet shkencore por mbi t谷 gjitha p谷r shoq谷rin谷 humane.Tashm谷 谷sht谷 b谷r谷 m谷 e leht谷 p谷r ti b谷r谷 ball谷 s谷mundjeve malinje.
  • 13. https://en.wikipedia.org/wiki/Aziz_Sancar https://en.wikipedia.org/wiki/Nucleotide_excisio n_repair http://www.med.unc.edu/biochem/people/facult y/primary/asancar http://www.nobelprize.org/nobel_prizes/chemist ry/laureates/2015/popular- chemistryprize2015.pdf