bacterias de peixe
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This document summarizes research presented at the XXVII Brazilian Congress in Biomedical Engineering on developing new drugs from maleimides to combat bacteria in tambaqui fish. Key findings include: - Synthesis and characterization of methyl 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl) benzoate, which achieved 68% yield and was supported by NMR and mass spectrometry data. - Determination of minimum inhibitory concentrations and minimum bactericidal concentrations of synthesized compounds against A. jandaei and A. hydrophila bacteria, with compounds B, C, D, and E showing potential antimicrobial activity. - Evaluation of
bacterias de peixe
- 1. XXVII Brazilian Congress in BiomedicalEngineering(CBEB 2020) October26-30 2020 Vitoria(Brazil) Pesquisas com maleimidas contra bact辿rias de tambaqui
- 2. MBR Technology LTDA Dra. Claire Juliana Francisco
- 4. (Peixe BR, 2020) 4,9% Produ巽達o aqu鱈cola brasileira: 758.000 t Tambaqui (Colossoma macropomum); Matrinx達 (Brycon amazonicus); Pirarucu (Arapaima gigas). 20.596 t . AMAZONAS Disciplina Procad 2020
- 7. Subclasses de Imidas Antividade antimicrobiana Disciplina Procad 2020
- 8. A B C Disciplina Procad 2020
- 11. Sintese
- 12. XXVII Brazilian Congressin BiomedicalEngineering(CBEB 2020) October26-30 2020 Vitoria(Brazil) Caracteriza巽ao Methyl 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1- yl) benzoate. HPLC-Exact Mass calculated for C12H10NO4 232.0604 (M + 1), and determined at 232.0609. 68% Disciplina Procad 2020
- 13. XXVII Brazilian Congressin BiomedicalEngineering(CBEB 2020) October26-30 2020 Vitoria(Brazil) Caracteriza巽ao Spectrum of RMN 1H, in CDCl3 a 500 MHz 4- (2,5-dioxo-2,5- dihydro-1H-pyrrol-1-yl) benzoate. Spectrum of RMN 13C, in CDCl3 a 125 MHz 4-(2,5- dioxo-2,5- dihydro-1H-pyrrol-1-yl) benzoate. Disciplina Procad 2020
- 16. MALDI-TOF Biologia Molecular Disciplina Procad 2020 PESQUISA
- 17. A B C D E F Disciplina Procad 2020 PESQUISA
- 18. (MUT)=mutag棚nico; (TUM)=tumorogenico; (IRRI)=Irritante; (REP)=Interferencia na reprodu巽達o); (PM)=peso molecular; (cLogP)=hidrofilicidade; (SOL)=solubilidade; (DL)=druglikeness (DS)= drugscore Disciplina Procad 2020 PESQUISA
- 19. RESULTADOS Concentra巽達o M鱈nima Inibit坦ria (CIM) e Concentra巽達o M鱈nima Bactericida (CBM) Mol辿cula A. jandaei (袖g/mL) A. hydrophila (袖g/mL) CIM CBM CBM/CIM CIM CBM CBM/CIM A >1000 - - >1000 - - B 62,5 62,5 1 125 125 1 C 62,5 62,5 1 62,5 62,5 1 D 62,5 62,5 1 250 250 1 E 166,25 166,25 1 166,25 166,25 1 F 500 500 1 500 500 1 G >1000 - - >1000 - - Disciplina Procad 2020
- 20. Riscos de toxicidade Farmacocin辿tico Drug F坦rmula qu鱈mica MUT TUM IRRI REP PM cLogP SOL DL DS (A) C28H43NO2 425,0 8,77 -6,9 -24,9 0,12 (B) C12H12N202 216,0 0,64 -2,11 -13,02 0,17 (C) C12H9NO2 199,0 1,45 -2,88 -9,86 0,22 (D) C10H6ClNO2 207,0 1,35 -2,81 -6,31 0,28 (E) C10H7NO2 173,0 0,74 -2,07 -4,49 0,29 (F) C11H7NO4 217,0 0,23 -2,09 -8,11 0,48 (G) C15H15NO4 273,0 1,8 -3,0 -30,33 0,27 Oxitetraciclina 460,0 2,18 -1,45 5,36 0,8 Florfenicol 357,0 0,2 -2,91 2,55 0,11 Avalia巽達o da citotoxicidade Disciplina Procad 2020 RESULTADOS
- 22. XXVII Brazilian Congress in BiomedicalEngineering(CBEB 2020) October26-30 2020 Vitoria(Brazil) Dra. Claire JulianaFrancisco email: aquicultura2005@hotmail.com Obrigada