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Banned in Singapore!

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Michael Fraser
Michael Fraser

This document proposes using chewing gum as a delivery method for over-the-counter pharmaceuticals. It notes that chewing gum has a long history and is a multi-billion dollar industry. The document outlines how drugs could be loaded into biodegradable microspheres and released through chewing gum over a sustained period. This approach could reduce medical costs and increase access to care. It discusses testing nicotine and aspirin through this method and developing the business model, including crowd funding and FDA approval. The goal is to deliver drugs non-invasively for conditions like allergies, coughs, and skin issues.

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Banned in Singapore! Presented by Gray Ghosts 1
Brief History and Economic Impact Chewing gum has a 5,000 year history! Post-WWII, ingredients shifted to more artificial mixes more like polymers now Sales exceed $20 Billion per year! 2
Traditional Uses Glue or sealer Blow bubbles (bubble gum) Relaxation Breath cleanser Window putty 3
Artistic Uses Sculpture Base for miniature painting Wall paper Wrapper origami shapes 4
Interesting Uses Insect repellant (spearmint oil) Bait for catfish or crabs Political advertising on wrappers Personalized party favors Weight loss Peak performance enhancer for tests Recycled as running track or fertilizer 5
Re-Framed Use Non-invasive drug delivery for Over The Counter (OTC) pharmaceuticals US Market $23 Billion in 2010 Benefits estimated at $6-7 per $1 of sales or Range of $138 to 161 Billion times 3 per cent Estimate Value = $4.14 4.83 Billion per year (Consumer Health-US, Enomaster Intl, 2011) 6
Expected Benefits Reduce number of sick days Reduce time off from work for medical office visits Increase access for medical care for 180 Million US residents Avoid the need for costly prescription drugs (Knowledge Network Survey) 7
How Would It Work? Drugs loaded in biodegradable microspheres Size up to 1 mm Drugs best matched for sustained release over a specific period of time 8
Goals Deliver a pharmaceutical compound to the body as needed to safely achieve the desired therapeutic effect. Modify the drug release profile absorption, distribution, and elimination for the benefit of improving product efficiency, safety as well as patient convenience and compliance. 9
Over The Counter (OTC) Target Areas Allergies Analgesics Anti-fungal Cough/colds/flu Lower/upper Gastrointestinal (GI) tract Medicated skin 10
Possible Pathways for Treatments By mouth Topical (skin) Nasal Vaginal, ocular, rectal or inhalation 11
Have Similar Approaches Ever Been Tested? Nicotine Aspirin 12
Solution Avoids Most Delivery Problems Some drugs require injection or nano-needles to administer because of molecule size or charge issues Others are susceptible to enzyme degradation No known additional allergy problems 13
Next Steps Use Kickstarter to crowd source startup funding Evolve the Business Case Canvas Complete a pilot that can scale up Identify and form partnerships Finish any required FDA testing 14
Customer Discovery Philosophy Ascertain whether theres product/market fit by finding early evangelists, understanding their needs, and verifying that the initial minimum viable product (MVP) solves a problem theyll eagerly pay to have solved. If not, use near-continuous customer feedback to drive agile, frequent changes in product and business model alike. 15
Key Partners (Others essential to success of business) Key Activities (Potential show stoppers) (Critical path) Value Proposition (Market size; Product/Service) (What is the product/service, its benefits, and MVP) Market type hypothesis and competitive set differentiation Customer Relationships (How will demand be created?) Customer Segments (Who is the customer and what problems the product solves?) Key Resources (Suppliers, commodities or other essential elements) Channels (How distributed and sold?) Cost Structure (Inside sales/field sales, development costs, infrastructure costs, support costs) Revenue Streams (Revenue and profit sources and size) Business Model Canvas (Blank and Dorf, 2012) 16
Forward! Are there any questions or comments? 17

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Banned in Singapore!

  • 2. Brief History and Economic Impact Chewing gum has a 5,000 year history! Post-WWII, ingredients shifted to more artificial mixes more like polymers now Sales exceed $20 Billion per year! 2
  • 3. Traditional Uses Glue or sealer Blow bubbles (bubble gum) Relaxation Breath cleanser Window putty 3
  • 4. Artistic Uses Sculpture Base for miniature painting Wall paper Wrapper origami shapes 4
  • 5. Interesting Uses Insect repellant (spearmint oil) Bait for catfish or crabs Political advertising on wrappers Personalized party favors Weight loss Peak performance enhancer for tests Recycled as running track or fertilizer 5
  • 6. Re-Framed Use Non-invasive drug delivery for Over The Counter (OTC) pharmaceuticals US Market $23 Billion in 2010 Benefits estimated at $6-7 per $1 of sales or Range of $138 to 161 Billion times 3 per cent Estimate Value = $4.14 4.83 Billion per year (Consumer Health-US, Enomaster Intl, 2011) 6
  • 7. Expected Benefits Reduce number of sick days Reduce time off from work for medical office visits Increase access for medical care for 180 Million US residents Avoid the need for costly prescription drugs (Knowledge Network Survey) 7
  • 8. How Would It Work? Drugs loaded in biodegradable microspheres Size up to 1 mm Drugs best matched for sustained release over a specific period of time 8
  • 9. Goals Deliver a pharmaceutical compound to the body as needed to safely achieve the desired therapeutic effect. Modify the drug release profile absorption, distribution, and elimination for the benefit of improving product efficiency, safety as well as patient convenience and compliance. 9
  • 10. Over The Counter (OTC) Target Areas Allergies Analgesics Anti-fungal Cough/colds/flu Lower/upper Gastrointestinal (GI) tract Medicated skin 10
  • 11. Possible Pathways for Treatments By mouth Topical (skin) Nasal Vaginal, ocular, rectal or inhalation 11
  • 12. Have Similar Approaches Ever Been Tested? Nicotine Aspirin 12
  • 13. Solution Avoids Most Delivery Problems Some drugs require injection or nano-needles to administer because of molecule size or charge issues Others are susceptible to enzyme degradation No known additional allergy problems 13
  • 14. Next Steps Use Kickstarter to crowd source startup funding Evolve the Business Case Canvas Complete a pilot that can scale up Identify and form partnerships Finish any required FDA testing 14
  • 15. Customer Discovery Philosophy Ascertain whether theres product/market fit by finding early evangelists, understanding their needs, and verifying that the initial minimum viable product (MVP) solves a problem theyll eagerly pay to have solved. If not, use near-continuous customer feedback to drive agile, frequent changes in product and business model alike. 15
  • 16. Key Partners (Others essential to success of business) Key Activities (Potential show stoppers) (Critical path) Value Proposition (Market size; Product/Service) (What is the product/service, its benefits, and MVP) Market type hypothesis and competitive set differentiation Customer Relationships (How will demand be created?) Customer Segments (Who is the customer and what problems the product solves?) Key Resources (Suppliers, commodities or other essential elements) Channels (How distributed and sold?) Cost Structure (Inside sales/field sales, development costs, infrastructure costs, support costs) Revenue Streams (Revenue and profit sources and size) Business Model Canvas (Blank and Dorf, 2012) 16
  • 17. Forward! Are there any questions or comments? 17

Editor's Notes

  • #17: Story about Steve Blank and warranty cards. Most recent 300 and customer follow-up. All because he was observant.