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Bevor get labeled as ME patient 2009

Institut for Symptom Research
Institut for Symptom Research

The Question is how to deal with the rest of the symptoms while taking a high doses of oral Doxicycline?

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Sheet 1 Analysis of the progress of an antibiotic therapy to control the typical symptoms of the Lyme borreliosis infection of G. Torbohm
Sheet 2 The meaning of the following numbers 0 = no symptoms 1 = low symptoms 2 = constant mild symptoms 3 = constant symptoms 4 = constant strong Symptoms 5 = deep impact on ability to work 6 = heavy impact on ability to anything 7 = etc
Sheet 3 Data basis for the following analysis of progress in a case of Lyme borreliosis. February 2009 Symptoms of Gunnar Torbohm Day: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 Arthritis in knees, elbows etc. 2 3 4 3 3 4 3 4 2 3 3 2 3 2 3 3 4 5 5 4 3 2 1 0 0 0 0 0 Stiff or painful neck 3 3 2 2 2 3 3 2 2 3 3 3 2 2 2 3 2 2 2 2 3 3 2 2 1 1 1 1 Meningitis infection 4 4 3 3 3 4 3 3 3 3 3 4 3 3 3 3 3 4 3 3 3 2 2 1 1 1 1 1 Constant headache 4 4 3 3 3 4 4 3 3 3 4 4 3 3 3 4 5 5 4 4 3 2 1 0 0 0 0 0 Missing ability to concentrate 2 4 2 1 1 4 4 1 1 1 3 2 1 1 2 0 2 4 4 4 3 1 0 0 0 0 0 0 Brain fog 2 4 2 1 1 4 4 1 1 1 3 2 1 1 2 0 2 4 4 4 3 1 0 0 0 0 0 0 Fatigue 2 3 2 2 3 3 2 2 3 3 2 2 2 3 2 2 5 5 5 3 2 2 1 0 0 0 0 0 Missing energy in the morning 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Numbness in face/extremities 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Conjunctivitis night + morning 4 3 3 4 4 3 3 4 4 4 3 3 4 3 3 4 5 5 6 5 4 4 2 2 2 2 2 2 Irritable bladder 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 4 4 4 4 4 4 4 4 4 4 4 Constant pain in liver 3 3 3 2 2 2 1 1 2 2 2 3 2 2 2 2 3 3 2 1 0 0 0 0 0 0 0 0 Muscle pain or cramps 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 3 4 4 4 3 3 2 0 0 0 0 0 Pain in prostate gland 2 2 1 1 1 2 2 1 1 2 2 1 1 2 1 1 2 2 2 3 3 4 4 4 3 3 3 2 Quality of sleep in the night 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Verbal competencies 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Missing energy during day 4 0 0 3 3 4 3 2 4 3 2 2 0 2 4 2 5 4 5 5 4 3 4 3 3 2 1 1 Tachycardia; racing heart at night 2 2 2 2 1 1 1 1 2 2 2 1 1 1 2 2 3 3 3 3 2 2 2 2 1 1 0 0 Bone pain, joint pain 2 2 3 2 2 2 3 3 2 2 2 3 2 2 2 2 4 5 4 3 2 1 0 0 0 0 0 0 Pain in the region of the heart 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Shortness of breath 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Serious stomach problems 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 3 1 Fungal infection 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 3 4 3 2 1 Therapy 1 Doxycycline 400 mg/d, 2X2, 9:00am/9:00pm Nothing at all for about 24 months Therapy 2 Fluconazol 200mg/d X X Accumulation 38 39 32 31 31 42 38 30 32 34 36 34 27 29 33 31 51 59 57 52 42 34 26 21 24 22 17 13 Specials A B C Mo. Mo. Mo. Mo. Do. Do. Do. Do. Mi. Mi. Mi. Mi. So. So. So. So. Di. Sa. Di. Di. Di. Sa. Sa. Sa. Fr. Fr. Fr. Fr. Day of the week:
Sheet 4 Data basis for the following analysis of progress in a case of Lyme borreliosis. March 2009 Symptoms of G. Torbohm Day: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Arthritis in knees, elbows etc. 1 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Stiff or painful neck 1 1 1 1 1 1 0 0 0 0 1 1 1 1 2 2 2 2 2 1 1 1 1 1 2 3 3 2 2 2 2 Meningitis infection 1 1 1 1 1 1 1 1 2 2 2 2 3 3 3 3 3 3 3 2 2 2 2 2 3 4 4 4 3 2 3 Constant headache 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 1 1 Missing ability to concentrate 0 0 0 0 0 0 0 0 0 0 1 1 2 2 2 2 2 2 2 2 1 1 1 0 1 2 2 2 1 0 1 Brain fog 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 2 2 1 0 0 Fatigue 0 0 0 0 0 0 0 0 0 3 3 1 0 0 0 0 0 0 0 0 0 0 0 0 1 2 2 2 1 0 0 Missing energy in the morning 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Numbness in face/extremities 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Conjunctivitis night + morning 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Irritable bladder 4 3 2 2 1 1 1 1 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 2 2 2 1 1 Constant pain in liver 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Muscle pain or cramps 0 0 0 0 0 0 4 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Pain in prostate gland 2 1 1 1 1 1 1 1 1 1 0 0 0 1 0 0 1 0 0 1 0 0 0 0 1 2 1 0 0 1 1 Quality of sleep in the night 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Verbal competencies 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Missing energy during day 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 2 2 2 2 1 0 0 Tachycardia; racing heart at night 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 1 2 Bone pain, joint pain 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Pain in the region of the heart 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 2 Shortness of breath 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Serious stomach problems 2 3 4 4 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 1 0 0 0 0 0 0 1 1 Fungal infection 1 0 0 0 0 0 0 0 2 3 3 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ? ? Therapie 1 2X200 mg/d ----------Doxycycline 300 mg/d 3X1------------ 2 X 200 mg/d Doxycycline 9:00am/9:00pm Therapie 2 Fluconazol 100mg/d !!! X X accumulation 14 11 11 11 5 5 8 6 8 12 11 7 8 9 9 9 10 10 9 8 7 6 8 8 15 22 23 21 15 7 6 specials D E F G Photo-toxic-reaction on the nose H Mo. Mo. Mo. Mo. Mo. Do. Do. Do. Do. Mi. Mi. Mi. Mi. So. So. So. So. So. Sa. Sa. Di. Di. Sa. Di. Sa. Di. Di. Fr. Fr. Fr. Fr. day of the week:
Sheet 5 Data basis for the following analysis of progress in a case of Lyme borreliosis April 2009 Symptoms of G. Torbohm day: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 Arthritis in knees, elbows etc. 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Stiff or painful neck 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 Meningitis infection 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 Constant headache 2 2 2 2 1 1 1 1 2 2 2 1 1 2 2 2 2 2 Missing ability to concentrate 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Brain fog 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Fatigue 4 2 0 0 2 1 0 0 2 0 0 0 2 0 2 2 0 2 Missing energy in the morning 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Numbness in face/extremities 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Conjunctivitis night + morning 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Irritable bladder 1 1 1 1 1 0 0 0 1 1 1 0 0 0 1 1 1 0 Constant pain in liver 0 0 1 1 1 1 0 0 1 0 0 1 1 0 0 1 1 1 Muscle pain or cramps 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Pain in prostate gland 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Quality of sleep in the night 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Verbal competencies 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Missing energy during day 2 1 0 0 0 0 0 0 2 0 0 2 2 0 0 2 2 1 Tachycardia; racing heart at night 2 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Bone pain, joint pain 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Pain in the region of the heart 2 2 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Shortness of breath 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Serious stomach problems 4 3 2 1 0 0 0 0 1 1 0 1 1 1 1 0 0 0 Fungal infection ? ? ? ? ? ? ? 0 0 0 0 0 0 0 0 0 0 0 Therapie 1 Doxycycline 400mg Therapie 2 Fluconazol X X X X X . accumulation 17 13 10 10 11 10 8 8 14 9 9 11 13 9 11 14 12 13 specials I Mo. Mo. Mo. Mo. Do. Do. Do. Do. Do. Mi. Mi. Mi. Mi. Mi. So. So. So. So. Sa. Sa. Di. Di. Sa. Di. Sa. Di. Fr. Fr. Fr. Fr. day of the week:
Sheet 6 Specials A: Start of Doxycycline 300-400 mg a day. B: 4 days in bed, sleeping, strong pains, poor concentration C: Symptoms of fungal infection D: Serious stomach problems change from 400 (2X2) to 300 mg (100X3)!!! E: First time dancing after 15 jeers F: Symptoms of fungal infection G: Photo-toxic-reaction on the nose H: 2 days in bed, sleeping, strong pains, poor concentration I: There is a microbiological, scientific explanation behind the rest of the symptoms!?
Sheet 7 - Overview without further information Graphic analysis of a therapy period with Doxicycline under the Diagnosis of a Lyme disease infection of Mr G. Torbohm starting on the16th February 2009. Serie1 A B C D E F H 1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55 57 59
Sheet 8 - The level of Doxicycline and the progress of the symptoms Graphic analysis of a therapy period with Doxicycline under the Diagnosis of a Lyme disease infection of Mr G. Torbohm starting on 16 February 2009. Start Serie1 February March 09 2 X 200 mg Doxycyclin / d 3 X 100 mg Doxycyclin / d 2 X 200 mg Doxycyclin / d 1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55 57 59
Sheet 9 - Moments of a rising level in the symptoms Graphic analysis of a therapy period with Doxicycline under the Diagnosis of a Lyme disease infection of Mr G. Torbohm starting on 16 February 2009. Serie1 Start February March 09 ? ? ? ? 1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55 57 59
Sheet 10 Explanations of the rising level of symptoms Graphic analysis of a therapy period with Doxicycline under the Diagnosis of a Lyme disease infection of Mr G. Torbohm starting on 16 February 2009. Serie1 Start February March 09 Why is the progress stopping ? Herxheimer- Fluconazol Reaction ? Disco Fluconazol 1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55 57 59
Sheet 11 - Overview of progress without further information from the16th February to the 18th of April 2009. The Question is how to deal with the rest of the symptoms while taking a high doses of oral Doxicycline? ? February March April 1 4 7 10 13 16 19 22 25 28 31 34 37 40 43 46 49 52 55 58 61 64 67 70 73 76
Sheet 12 The current treatment started after two years without any pharmaceutics therapy at all. Lets have a closer look on some of the symptoms at the beginning of the therapy and their response to Doxycycline.
The beginning of the therapy cycle on the 16the of February 09. Sheet 13 The red arrow represents the progress in a short form Symptoms of: Gunnar Torbohm Day: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 Arthritis in knees, elbows etc. 2 3 4 3 3 4 3 4 2 3 3 2 3 2 3 3 4 5 5 4 3 2 1 0 0 0 0 0 ? Stiff or painful neck 3 3 2 2 2 3 3 2 2 3 3 3 2 2 2 3 2 2 2 2 3 3 2 2 1 1 1 1 ? Meningitis infection 4 4 3 3 3 4 3 3 3 3 3 4 3 3 3 3 3 4 3 3 3 2 2 1 1 1 1 1 ? Constant headache 4 4 3 3 3 4 4 3 3 3 4 4 3 3 3 4 5 5 4 4 3 2 1 0 0 0 0 0 ? Missing ability to ? concentrate 2 4 2 1 1 4 4 1 1 1 3 2 1 1 2 0 2 4 4 4 3 1 0 0 0 0 0 0 Fatigue 2 3 2 2 3 3 2 2 3 3 2 2 2 3 2 2 5 5 5 3 2 2 1 0 0 0 0 0 ? Conjunctivitis night + ? morning 4 3 3 4 4 3 3 4 4 4 3 3 4 3 3 4 5 5 6 5 4 4 2 2 2 2 2 2 Constant pain in liver 3 3 3 2 2 2 1 1 2 2 2 3 2 2 2 2 3 3 2 1 0 0 0 0 0 0 0 0 ? Muscle pain or ?X cramps 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 3 4 4 4 3 3 2 0 0 0 0 0 Pain in prostate ? gland 2 2 1 1 1 2 2 1 1 2 2 1 1 2 1 1 2 2 2 3 3 4 4 4 3 3 3 2 Missing energy ? during day 4 0 0 3 3 4 3 2 4 3 2 2 0 2 4 2 5 4 5 5 4 3 4 3 3 2 1 1 Bone pain, joint pain 2 2 3 2 2 2 3 3 2 2 2 3 2 2 2 2 4 5 4 3 2 1 0 0 0 0 0 0 ? Accumulation 38 39 32 31 31 42 38 30 32 34 36 34 27 29 33 31 51 59 57 52 42 34 26 21 24 22 17 13
Sheet 14 Lets have a closer look to the symptoms are left under a powerful Doxycycline therapy and their location in the different body systems after about 60 Days of treatment.
Sheet 15 The red arrow represents the progress in a short form. The X symbolises a non significant progress of a symptom. Symptoms of: Gunnar Torbohm in April 2009 Day: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 Arthritis in knees, etc. 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Stiff or painful neck 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 ? Meningitis infection 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 ? Constant headache 2 2 2 2 1 1 1 1 2 2 2 1 1 2 2 2 2 2 ? Concentration 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0X Fatigue 4 2 0 0 2 1 0 0 2 0 0 0 2 0 2 2 0 2 ? Conjunctivitis 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 ? Constant pain in liver 0 0 1 1 1 1 0 0 1 0 0 1 1 0 0 1 1 1 ? Muscle pain or cramps 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0X Pain in prostate gland 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 ? Missing energy during ? 2 1 0 0 0 0 0 0 2 0 0 2 2 0 0 2 2 1 day Bone pain, joint pain 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0X Accumulation 17 13 10 10 11 10 8 8 14 9 9 11 13 9 11 14 12 13
Sheet 16 It seems that some of the persistent symptoms are related to the brain-blood-barrier. This also explains the symptoms in the prostate gland and the conjunctivitis! Nervous system Joints Stiff or painful neck Arthritis in knees, etc. Meningitis infection Stiff or painful neck Constant headache Fatigue Conjunctivitis Pain in prostate gland Missing energy during day
Sheet 17 To me there occur two questions I would like to ask you as my doctor. Is there evident research on the effectiveness of different antibiotics and their concentrations including Doxycycline to eradicate different genospecies of Borrelia burgdorferi sensu lato? & How to get a constant and significant influence on the persisting symptoms?
Sheet 18 The answer to the first question is yes: The Dissertation of Dr. Martin Sicklinger analyses the in-vitro-sensitivity of Borrelia burgdorferi sensu lato against four different Antibiotics. A comparison of genospecies Borrelia afzelii, Borrelia garinii and Borrelia burgdorferi sensu stricto. University of Munich 2006
Sheet 19 Abstract of this Dissertation Amoxicillin was especially effective against Borrelia burgdorferi sensu stricto, Azithromycin showed very good results against Borrelia garinii, while Borrelia afzelii reacted very sensitive to Ceftriaxon. Doxycycline showed evidently worse results in this in-vitro-test and on top of that the highest range of clusters in the test results.
Sheet 20 The answer to the second question is still open. Please give me advise about the next steps of treatment. Dr. Powell New Hayesbank Surgery, Bybrook, Kennington, Ashford, Kent, TN24 9JZ is still open to support my therapy and asks for advice too. It would be helpful if you could send a short letter of advice.

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Bevor get labeled as ME patient 2009

  • 1. Sheet 1 Analysis of the progress of an antibiotic therapy to control the typical symptoms of the Lyme borreliosis infection of G. Torbohm
  • 2. Sheet 2 The meaning of the following numbers 0 = no symptoms 1 = low symptoms 2 = constant mild symptoms 3 = constant symptoms 4 = constant strong Symptoms 5 = deep impact on ability to work 6 = heavy impact on ability to anything 7 = etc
  • 3. Sheet 3 Data basis for the following analysis of progress in a case of Lyme borreliosis. February 2009 Symptoms of Gunnar Torbohm Day: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 Arthritis in knees, elbows etc. 2 3 4 3 3 4 3 4 2 3 3 2 3 2 3 3 4 5 5 4 3 2 1 0 0 0 0 0 Stiff or painful neck 3 3 2 2 2 3 3 2 2 3 3 3 2 2 2 3 2 2 2 2 3 3 2 2 1 1 1 1 Meningitis infection 4 4 3 3 3 4 3 3 3 3 3 4 3 3 3 3 3 4 3 3 3 2 2 1 1 1 1 1 Constant headache 4 4 3 3 3 4 4 3 3 3 4 4 3 3 3 4 5 5 4 4 3 2 1 0 0 0 0 0 Missing ability to concentrate 2 4 2 1 1 4 4 1 1 1 3 2 1 1 2 0 2 4 4 4 3 1 0 0 0 0 0 0 Brain fog 2 4 2 1 1 4 4 1 1 1 3 2 1 1 2 0 2 4 4 4 3 1 0 0 0 0 0 0 Fatigue 2 3 2 2 3 3 2 2 3 3 2 2 2 3 2 2 5 5 5 3 2 2 1 0 0 0 0 0 Missing energy in the morning 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Numbness in face/extremities 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Conjunctivitis night + morning 4 3 3 4 4 3 3 4 4 4 3 3 4 3 3 4 5 5 6 5 4 4 2 2 2 2 2 2 Irritable bladder 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 4 4 4 4 4 4 4 4 4 4 4 Constant pain in liver 3 3 3 2 2 2 1 1 2 2 2 3 2 2 2 2 3 3 2 1 0 0 0 0 0 0 0 0 Muscle pain or cramps 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 3 4 4 4 3 3 2 0 0 0 0 0 Pain in prostate gland 2 2 1 1 1 2 2 1 1 2 2 1 1 2 1 1 2 2 2 3 3 4 4 4 3 3 3 2 Quality of sleep in the night 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Verbal competencies 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Missing energy during day 4 0 0 3 3 4 3 2 4 3 2 2 0 2 4 2 5 4 5 5 4 3 4 3 3 2 1 1 Tachycardia; racing heart at night 2 2 2 2 1 1 1 1 2 2 2 1 1 1 2 2 3 3 3 3 2 2 2 2 1 1 0 0 Bone pain, joint pain 2 2 3 2 2 2 3 3 2 2 2 3 2 2 2 2 4 5 4 3 2 1 0 0 0 0 0 0 Pain in the region of the heart 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Shortness of breath 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Serious stomach problems 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 3 1 Fungal infection 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 3 4 3 2 1 Therapy 1 Doxycycline 400 mg/d, 2X2, 9:00am/9:00pm Nothing at all for about 24 months Therapy 2 Fluconazol 200mg/d X X Accumulation 38 39 32 31 31 42 38 30 32 34 36 34 27 29 33 31 51 59 57 52 42 34 26 21 24 22 17 13 Specials A B C Mo. Mo. Mo. Mo. Do. Do. Do. Do. Mi. Mi. Mi. Mi. So. So. So. So. Di. Sa. Di. Di. Di. Sa. Sa. Sa. Fr. Fr. Fr. Fr. Day of the week:
  • 4. Sheet 4 Data basis for the following analysis of progress in a case of Lyme borreliosis. March 2009 Symptoms of G. Torbohm Day: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Arthritis in knees, elbows etc. 1 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Stiff or painful neck 1 1 1 1 1 1 0 0 0 0 1 1 1 1 2 2 2 2 2 1 1 1 1 1 2 3 3 2 2 2 2 Meningitis infection 1 1 1 1 1 1 1 1 2 2 2 2 3 3 3 3 3 3 3 2 2 2 2 2 3 4 4 4 3 2 3 Constant headache 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 1 1 Missing ability to concentrate 0 0 0 0 0 0 0 0 0 0 1 1 2 2 2 2 2 2 2 2 1 1 1 0 1 2 2 2 1 0 1 Brain fog 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 2 2 1 0 0 Fatigue 0 0 0 0 0 0 0 0 0 3 3 1 0 0 0 0 0 0 0 0 0 0 0 0 1 2 2 2 1 0 0 Missing energy in the morning 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Numbness in face/extremities 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Conjunctivitis night + morning 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Irritable bladder 4 3 2 2 1 1 1 1 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 2 2 2 1 1 Constant pain in liver 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Muscle pain or cramps 0 0 0 0 0 0 4 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Pain in prostate gland 2 1 1 1 1 1 1 1 1 1 0 0 0 1 0 0 1 0 0 1 0 0 0 0 1 2 1 0 0 1 1 Quality of sleep in the night 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Verbal competencies 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Missing energy during day 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 2 2 2 2 1 0 0 Tachycardia; racing heart at night 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 1 2 Bone pain, joint pain 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Pain in the region of the heart 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 2 Shortness of breath 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Serious stomach problems 2 3 4 4 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 1 0 0 0 0 0 0 1 1 Fungal infection 1 0 0 0 0 0 0 0 2 3 3 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ? ? Therapie 1 2X200 mg/d ----------Doxycycline 300 mg/d 3X1------------ 2 X 200 mg/d Doxycycline 9:00am/9:00pm Therapie 2 Fluconazol 100mg/d !!! X X accumulation 14 11 11 11 5 5 8 6 8 12 11 7 8 9 9 9 10 10 9 8 7 6 8 8 15 22 23 21 15 7 6 specials D E F G Photo-toxic-reaction on the nose H Mo. Mo. Mo. Mo. Mo. Do. Do. Do. Do. Mi. Mi. Mi. Mi. So. So. So. So. So. Sa. Sa. Di. Di. Sa. Di. Sa. Di. Di. Fr. Fr. Fr. Fr. day of the week:
  • 5. Sheet 5 Data basis for the following analysis of progress in a case of Lyme borreliosis April 2009 Symptoms of G. Torbohm day: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 Arthritis in knees, elbows etc. 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Stiff or painful neck 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 Meningitis infection 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 Constant headache 2 2 2 2 1 1 1 1 2 2 2 1 1 2 2 2 2 2 Missing ability to concentrate 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Brain fog 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Fatigue 4 2 0 0 2 1 0 0 2 0 0 0 2 0 2 2 0 2 Missing energy in the morning 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Numbness in face/extremities 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Conjunctivitis night + morning 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Irritable bladder 1 1 1 1 1 0 0 0 1 1 1 0 0 0 1 1 1 0 Constant pain in liver 0 0 1 1 1 1 0 0 1 0 0 1 1 0 0 1 1 1 Muscle pain or cramps 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Pain in prostate gland 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Quality of sleep in the night 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Verbal competencies 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Missing energy during day 2 1 0 0 0 0 0 0 2 0 0 2 2 0 0 2 2 1 Tachycardia; racing heart at night 2 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Bone pain, joint pain 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Pain in the region of the heart 2 2 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Shortness of breath 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Serious stomach problems 4 3 2 1 0 0 0 0 1 1 0 1 1 1 1 0 0 0 Fungal infection ? ? ? ? ? ? ? 0 0 0 0 0 0 0 0 0 0 0 Therapie 1 Doxycycline 400mg Therapie 2 Fluconazol X X X X X . accumulation 17 13 10 10 11 10 8 8 14 9 9 11 13 9 11 14 12 13 specials I Mo. Mo. Mo. Mo. Do. Do. Do. Do. Do. Mi. Mi. Mi. Mi. Mi. So. So. So. So. Sa. Sa. Di. Di. Sa. Di. Sa. Di. Fr. Fr. Fr. Fr. day of the week:
  • 6. Sheet 6 Specials A: Start of Doxycycline 300-400 mg a day. B: 4 days in bed, sleeping, strong pains, poor concentration C: Symptoms of fungal infection D: Serious stomach problems change from 400 (2X2) to 300 mg (100X3)!!! E: First time dancing after 15 jeers F: Symptoms of fungal infection G: Photo-toxic-reaction on the nose H: 2 days in bed, sleeping, strong pains, poor concentration I: There is a microbiological, scientific explanation behind the rest of the symptoms!?
  • 7. Sheet 7 - Overview without further information Graphic analysis of a therapy period with Doxicycline under the Diagnosis of a Lyme disease infection of Mr G. Torbohm starting on the16th February 2009. Serie1 A B C D E F H 1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55 57 59
  • 8. Sheet 8 - The level of Doxicycline and the progress of the symptoms Graphic analysis of a therapy period with Doxicycline under the Diagnosis of a Lyme disease infection of Mr G. Torbohm starting on 16 February 2009. Start Serie1 February March 09 2 X 200 mg Doxycyclin / d 3 X 100 mg Doxycyclin / d 2 X 200 mg Doxycyclin / d 1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55 57 59
  • 9. Sheet 9 - Moments of a rising level in the symptoms Graphic analysis of a therapy period with Doxicycline under the Diagnosis of a Lyme disease infection of Mr G. Torbohm starting on 16 February 2009. Serie1 Start February March 09 ? ? ? ? 1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55 57 59
  • 10. Sheet 10 Explanations of the rising level of symptoms Graphic analysis of a therapy period with Doxicycline under the Diagnosis of a Lyme disease infection of Mr G. Torbohm starting on 16 February 2009. Serie1 Start February March 09 Why is the progress stopping ? Herxheimer- Fluconazol Reaction ? Disco Fluconazol 1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55 57 59
  • 11. Sheet 11 - Overview of progress without further information from the16th February to the 18th of April 2009. The Question is how to deal with the rest of the symptoms while taking a high doses of oral Doxicycline? ? February March April 1 4 7 10 13 16 19 22 25 28 31 34 37 40 43 46 49 52 55 58 61 64 67 70 73 76
  • 12. Sheet 12 The current treatment started after two years without any pharmaceutics therapy at all. Lets have a closer look on some of the symptoms at the beginning of the therapy and their response to Doxycycline.
  • 13. The beginning of the therapy cycle on the 16the of February 09. Sheet 13 The red arrow represents the progress in a short form Symptoms of: Gunnar Torbohm Day: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 Arthritis in knees, elbows etc. 2 3 4 3 3 4 3 4 2 3 3 2 3 2 3 3 4 5 5 4 3 2 1 0 0 0 0 0 ? Stiff or painful neck 3 3 2 2 2 3 3 2 2 3 3 3 2 2 2 3 2 2 2 2 3 3 2 2 1 1 1 1 ? Meningitis infection 4 4 3 3 3 4 3 3 3 3 3 4 3 3 3 3 3 4 3 3 3 2 2 1 1 1 1 1 ? Constant headache 4 4 3 3 3 4 4 3 3 3 4 4 3 3 3 4 5 5 4 4 3 2 1 0 0 0 0 0 ? Missing ability to ? concentrate 2 4 2 1 1 4 4 1 1 1 3 2 1 1 2 0 2 4 4 4 3 1 0 0 0 0 0 0 Fatigue 2 3 2 2 3 3 2 2 3 3 2 2 2 3 2 2 5 5 5 3 2 2 1 0 0 0 0 0 ? Conjunctivitis night + ? morning 4 3 3 4 4 3 3 4 4 4 3 3 4 3 3 4 5 5 6 5 4 4 2 2 2 2 2 2 Constant pain in liver 3 3 3 2 2 2 1 1 2 2 2 3 2 2 2 2 3 3 2 1 0 0 0 0 0 0 0 0 ? Muscle pain or ?X cramps 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 3 4 4 4 3 3 2 0 0 0 0 0 Pain in prostate ? gland 2 2 1 1 1 2 2 1 1 2 2 1 1 2 1 1 2 2 2 3 3 4 4 4 3 3 3 2 Missing energy ? during day 4 0 0 3 3 4 3 2 4 3 2 2 0 2 4 2 5 4 5 5 4 3 4 3 3 2 1 1 Bone pain, joint pain 2 2 3 2 2 2 3 3 2 2 2 3 2 2 2 2 4 5 4 3 2 1 0 0 0 0 0 0 ? Accumulation 38 39 32 31 31 42 38 30 32 34 36 34 27 29 33 31 51 59 57 52 42 34 26 21 24 22 17 13
  • 14. Sheet 14 Lets have a closer look to the symptoms are left under a powerful Doxycycline therapy and their location in the different body systems after about 60 Days of treatment.
  • 15. Sheet 15 The red arrow represents the progress in a short form. The X symbolises a non significant progress of a symptom. Symptoms of: Gunnar Torbohm in April 2009 Day: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 Arthritis in knees, etc. 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Stiff or painful neck 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 ? Meningitis infection 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 ? Constant headache 2 2 2 2 1 1 1 1 2 2 2 1 1 2 2 2 2 2 ? Concentration 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0X Fatigue 4 2 0 0 2 1 0 0 2 0 0 0 2 0 2 2 0 2 ? Conjunctivitis 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 ? Constant pain in liver 0 0 1 1 1 1 0 0 1 0 0 1 1 0 0 1 1 1 ? Muscle pain or cramps 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0X Pain in prostate gland 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 ? Missing energy during ? 2 1 0 0 0 0 0 0 2 0 0 2 2 0 0 2 2 1 day Bone pain, joint pain 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0X Accumulation 17 13 10 10 11 10 8 8 14 9 9 11 13 9 11 14 12 13
  • 16. Sheet 16 It seems that some of the persistent symptoms are related to the brain-blood-barrier. This also explains the symptoms in the prostate gland and the conjunctivitis! Nervous system Joints Stiff or painful neck Arthritis in knees, etc. Meningitis infection Stiff or painful neck Constant headache Fatigue Conjunctivitis Pain in prostate gland Missing energy during day
  • 17. Sheet 17 To me there occur two questions I would like to ask you as my doctor. Is there evident research on the effectiveness of different antibiotics and their concentrations including Doxycycline to eradicate different genospecies of Borrelia burgdorferi sensu lato? & How to get a constant and significant influence on the persisting symptoms?
  • 18. Sheet 18 The answer to the first question is yes: The Dissertation of Dr. Martin Sicklinger analyses the in-vitro-sensitivity of Borrelia burgdorferi sensu lato against four different Antibiotics. A comparison of genospecies Borrelia afzelii, Borrelia garinii and Borrelia burgdorferi sensu stricto. University of Munich 2006
  • 19. Sheet 19 Abstract of this Dissertation Amoxicillin was especially effective against Borrelia burgdorferi sensu stricto, Azithromycin showed very good results against Borrelia garinii, while Borrelia afzelii reacted very sensitive to Ceftriaxon. Doxycycline showed evidently worse results in this in-vitro-test and on top of that the highest range of clusters in the test results.
  • 20. Sheet 20 The answer to the second question is still open. Please give me advise about the next steps of treatment. Dr. Powell New Hayesbank Surgery, Bybrook, Kennington, Ashford, Kent, TN24 9JZ is still open to support my therapy and asks for advice too. It would be helpful if you could send a short letter of advice.