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Stem Cells & Cloning 3/23/05
Bio Ethics
Timeline and
Controversies
Stem Cells & Cloning 3/23/05
What is Bio-Ethics?
? The study of the ethical and moral
implications of new biological
discoveries and biomedical
advances, as in the fields of genetic
engineering and drug research
? Examples?
Stem Cells & Cloning 3/23/05
Why Bioethics?
Stem Cells & Cloning 3/23/05
Current Bioethical Issues
? Check the local news paper
? Stem cells (state, national, international)
? Genetically Engineered Organisms
? Knowing your genes
? In vetro fertilization ¨C choosing your child's
genes and characteristics
? Chemicals exposures ¨C human health
? Environmental health
Stem Cells & Cloning 3/23/05
¡°The Commons¡±
The Tragedy of the Commons
By Garrett Hardin, Science, 1968
Stem Cells & Cloning 3/23/05
"Biology combined with diverse
humanistic knowledge forging a
science that sets a system of
medical and environmental
priorities for acceptable survival.¡°
Global Bioethics (1988)
Bioethics
-------- 1911 - 2001 --------
Van Rensselaer Potter
Stem Cells & Cloning 3/23/05
1860¡¯s - Scientific method in medicine, Gregor Mendel
1928 - Penicillin discovered ¨C widely used WWII
1920¡¯s - Lead in gasoline, lead in paint
1931 - 30 states had sterilization laws on books
1932 - Tuskegee syphilis study initiated
1947 - Nuremberg - The Doctors Trial
1952 - First open heart surgery & Chlorpromazine
1953 - Structure of DNA ¨C Watson & Crick
60¡¯s - Thalidomide, mercury, chronic hemodialysis,
amniocentesis, informed consent, IRB¡¯s
70¡¯s - Hastings Center founded, bioethics defined,
Tuskegee noticed
Ethics and Science
Stem Cells & Cloning 3/23/05
1973 ¨C Roe V. Wade Unrestricted access to abortion
1978- First Test Tube ever born
80¡¯s - Recombinant microorganism could be patented,
lead is harmful to developing brain
90¡¯s - molecular biology, sequencing of human
genome (other species), Jurassic Park
1996- Dolly the sheep is the first Mammal ever cloned
00¡¯s - US stem cell research restricted
2003- Human Genome project complete
? - Human cloned?
Ethics and Science
Stem Cells & Cloning 3/23/05
Human Clones?
Are there human clones?
Yes ¨C Identical Twins
(Time 2.19.01)
Stem Cells & Cloning 3/23/05
Cloning Defined
? What is cloning?
? Asexual reproduction
? Examples?
? Bacteria, fungus
? Plants ¨C cutting ¨C potato
? Farm animals
Stem Cells & Cloning 3/23/05
Cloning Dolly
1997 - 2003
(Roslin Institute http://www.roslin.ac.uk/library/)
Stem Cells & Cloning 3/23/05
Cloning A Sheep
(Roslin Institute http://www.roslin.ac.uk/library/)
Stem Cells & Cloning 3/23/05
IVF ¨C In Vitro Fertilization
? Baby conceived in a test tube and
implanted in a Uterus
? Available since 1986
? About 100,000 IVF kids in U.S.
? Often creates extra embryos some
would like to use for Stem Cell
research.
? U.S. - About 400,000 frozen embryos
(unregulated)
? England ¨C 52,000 (regulated by
government)
Stem Cells & Cloning 3/23/05
Controversies:
Should a mother be legally liable for
drinking or doing drugs while
pregnant? This of course would
cause harm to their unborn child.
Opinion?
Stem Cells & Cloning 3/23/05
Controversies:
? Should you be allowed to genetically
modify your children before they are
born to prevent disease?
? What about to change eye color,
make them taller, stronger, smarter,
better behaved?
? Opinion:
Stem Cells & Cloning 3/23/05
Controversies:
? Should college students be forced to
get the meningitis vaccine?
? Opinion
Stem Cells & Cloning 3/23/05
Controversies:
? Should food and chemical corporations
genetically modify food to yield more
product, make food more nutritious, or
make food taste better? Would you eat
this food?
? Opinion
Stem Cells & Cloning 3/23/05
Controversies:
? Should people be allowed to sell their
extra kidney or a portion of their liver to
a person in need of a transplant? This is
currently illegal
? Opinion

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Bio ethics

  • 1. Stem Cells & Cloning 3/23/05 Bio Ethics Timeline and Controversies
  • 2. Stem Cells & Cloning 3/23/05 What is Bio-Ethics? ? The study of the ethical and moral implications of new biological discoveries and biomedical advances, as in the fields of genetic engineering and drug research ? Examples?
  • 3. Stem Cells & Cloning 3/23/05 Why Bioethics?
  • 4. Stem Cells & Cloning 3/23/05 Current Bioethical Issues ? Check the local news paper ? Stem cells (state, national, international) ? Genetically Engineered Organisms ? Knowing your genes ? In vetro fertilization ¨C choosing your child's genes and characteristics ? Chemicals exposures ¨C human health ? Environmental health
  • 5. Stem Cells & Cloning 3/23/05 ¡°The Commons¡± The Tragedy of the Commons By Garrett Hardin, Science, 1968
  • 6. Stem Cells & Cloning 3/23/05 "Biology combined with diverse humanistic knowledge forging a science that sets a system of medical and environmental priorities for acceptable survival.¡° Global Bioethics (1988) Bioethics -------- 1911 - 2001 -------- Van Rensselaer Potter
  • 7. Stem Cells & Cloning 3/23/05 1860¡¯s - Scientific method in medicine, Gregor Mendel 1928 - Penicillin discovered ¨C widely used WWII 1920¡¯s - Lead in gasoline, lead in paint 1931 - 30 states had sterilization laws on books 1932 - Tuskegee syphilis study initiated 1947 - Nuremberg - The Doctors Trial 1952 - First open heart surgery & Chlorpromazine 1953 - Structure of DNA ¨C Watson & Crick 60¡¯s - Thalidomide, mercury, chronic hemodialysis, amniocentesis, informed consent, IRB¡¯s 70¡¯s - Hastings Center founded, bioethics defined, Tuskegee noticed Ethics and Science
  • 8. Stem Cells & Cloning 3/23/05 1973 ¨C Roe V. Wade Unrestricted access to abortion 1978- First Test Tube ever born 80¡¯s - Recombinant microorganism could be patented, lead is harmful to developing brain 90¡¯s - molecular biology, sequencing of human genome (other species), Jurassic Park 1996- Dolly the sheep is the first Mammal ever cloned 00¡¯s - US stem cell research restricted 2003- Human Genome project complete ? - Human cloned? Ethics and Science
  • 9. Stem Cells & Cloning 3/23/05 Human Clones? Are there human clones? Yes ¨C Identical Twins (Time 2.19.01)
  • 10. Stem Cells & Cloning 3/23/05 Cloning Defined ? What is cloning? ? Asexual reproduction ? Examples? ? Bacteria, fungus ? Plants ¨C cutting ¨C potato ? Farm animals
  • 11. Stem Cells & Cloning 3/23/05 Cloning Dolly 1997 - 2003 (Roslin Institute http://www.roslin.ac.uk/library/)
  • 12. Stem Cells & Cloning 3/23/05 Cloning A Sheep (Roslin Institute http://www.roslin.ac.uk/library/)
  • 13. Stem Cells & Cloning 3/23/05 IVF ¨C In Vitro Fertilization ? Baby conceived in a test tube and implanted in a Uterus ? Available since 1986 ? About 100,000 IVF kids in U.S. ? Often creates extra embryos some would like to use for Stem Cell research. ? U.S. - About 400,000 frozen embryos (unregulated) ? England ¨C 52,000 (regulated by government)
  • 14. Stem Cells & Cloning 3/23/05 Controversies: Should a mother be legally liable for drinking or doing drugs while pregnant? This of course would cause harm to their unborn child. Opinion?
  • 15. Stem Cells & Cloning 3/23/05 Controversies: ? Should you be allowed to genetically modify your children before they are born to prevent disease? ? What about to change eye color, make them taller, stronger, smarter, better behaved? ? Opinion:
  • 16. Stem Cells & Cloning 3/23/05 Controversies: ? Should college students be forced to get the meningitis vaccine? ? Opinion
  • 17. Stem Cells & Cloning 3/23/05 Controversies: ? Should food and chemical corporations genetically modify food to yield more product, make food more nutritious, or make food taste better? Would you eat this food? ? Opinion
  • 18. Stem Cells & Cloning 3/23/05 Controversies: ? Should people be allowed to sell their extra kidney or a portion of their liver to a person in need of a transplant? This is currently illegal ? Opinion

Editor's Notes

  • #10: Every cell contains a complete copy of ¡°the blueprint of life¡± DNA consists of two strands of nucleotides - 4 bases (A,G,T,C) 23 pairs of chromosomes If unwound and tied together, human DNA in one cell would stretch ~ 5 feet, but would be only 50 trillionths of an inch wide! Genes are specific sequences of DNA, each of which ¡°codes¡± for a protein with a specific function Genes are copied each time a cell divides, passing on the blueprint
  • #11: Every cell contains a complete copy of ¡°the blueprint of life¡± DNA consists of two strands of nucleotides - 4 bases (A,G,T,C) 23 pairs of chromosomes If unwound and tied together, human DNA in one cell would stretch ~ 5 feet, but would be only 50 trillionths of an inch wide! Genes are specific sequences of DNA, each of which ¡°codes¡± for a protein with a specific function Genes are copied each time a cell divides, passing on the blueprint
  • #12: Every cell contains a complete copy of ¡°the blueprint of life¡± DNA consists of two strands of nucleotides - 4 bases (A,G,T,C) 23 pairs of chromosomes If unwound and tied together, human DNA in one cell would stretch ~ 5 feet, but would be only 50 trillionths of an inch wide! Genes are specific sequences of DNA, each of which ¡°codes¡± for a protein with a specific function Genes are copied each time a cell divides, passing on the blueprint
  • #13: Every cell contains a complete copy of ¡°the blueprint of life¡± DNA consists of two strands of nucleotides - 4 bases (A,G,T,C) 23 pairs of chromosomes If unwound and tied together, human DNA in one cell would stretch ~ 5 feet, but would be only 50 trillionths of an inch wide! Genes are specific sequences of DNA, each of which ¡°codes¡± for a protein with a specific function Genes are copied each time a cell divides, passing on the blueprint
  • #14: Every cell contains a complete copy of ¡°the blueprint of life¡± DNA consists of two strands of nucleotides - 4 bases (A,G,T,C) 23 pairs of chromosomes If unwound and tied together, human DNA in one cell would stretch ~ 5 feet, but would be only 50 trillionths of an inch wide! Genes are specific sequences of DNA, each of which ¡°codes¡± for a protein with a specific function Genes are copied each time a cell divides, passing on the blueprint