birc-csd2012
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The document describes the Bioinformatics Research Centre (BiRC) in Denmark. It was established in 2001 and has approximately 45 employees, including researchers, PhD students, masters students, and programmers. The BiRC uses computers and algorithms to analyze biological data and answer questions in fields like evolutionary genomics, mathematical biology, medical genetics, and structural bioinformatics. It develops tools for applications such as gene annotation, sequence alignment, phylogenetic analysis, and protein modeling.
birc-csd2012
- 1. Paula Tataru paula@birc.au.dk 1/12www.birc.au.dk BioinformaticsComputer Science Day 2012
- 2. Paula Tataru paula@birc.au.dk 2/12www.birc.au.dk Bioinformatics Research Centre Established in 2001 ~45 BiRC-people VIP Christian Storm Pedersen (director), Thomas Mailund, S淡ren Besenbacher PhD Andreas Sand, Paula Tataru Master Daniel Kjeldsen, Jakob Sandholm, Carsten S淡rensen, Peter Sandberg Brun, Mads Sandberg Brun Programmers Kasper F淡ns, Anders Halager, Troels Hansen, Jacob Hougaard, Baban Ketabi
- 3. Paula Tataru paula@birc.au.dk 3/12www.birc.au.dk Bioinformatics? Using computers to answer biological questions. Developing and using algorithms and programs for collecting, handling and analyzing biological data. Combines biology, genetics, medicine, mathematics, statistics and computer science.
- 4. Paula Tataru paula@birc.au.dk 4/12www.birc.au.dk Research at BiRC Evolutionary genomics Mathematical biology Medical genetics Structural bioinformatics Algorithmic bioinformaticsa: 0.3 b: 0.7 a: 0.8 b: 0.2 a: 0.5 b: 0.5 0.9 0.1 0.4 0.6 1.0 0.1 0.9
- 5. Paula Tataru paula@birc.au.dk 5/12www.birc.au.dk Research at BiRC Evolutionary genomics Mathematical biology Medical genetics Structural bioinformatics Algorithmic bioinformaticsa: 0.3 b: 0.7 a: 0.8 b: 0.2 a: 0.5 b: 0.5 0.9 0.1 0.4 0.6 1.0 0.1 0.9
- 6. Paula Tataru paula@birc.au.dk 6/12www.birc.au.dk An automaton? An HMM? a b a b a a: 0.3 b: 0.7 a: 0.8 b: 0.2 a: 0.5 b: 0.5 0.9 0.1 0.4 0.6 1.0 0.1 0.9
- 7. Paula Tataru paula@birc.au.dk 7/12www.birc.au.dk Applications Bioinformatics Gene annotation Sequence alignment Phylogenetic analysis Protein modeling Other areas Speech recognition Gesture recognition Pervasive positioning a: 0.3 b: 0.7 a: 0.8 b: 0.2 a: 0.5 b: 0.5 0.9 0.1 0.4 0.6 1.0 0.1 0.9
- 8. Paula Tataru paula@birc.au.dk 8/12www.birc.au.dk Fundamental questions a: 0.3 b: 0.7 a: 0.8 b: 0.2 a: 0.5 b: 0.5 0.9 0.1 0.4 0.6 1.0 0.1 0.9X = Y = X's likelihood Prediction Y with highest joint probability a b b a b b a
- 9. Paula Tataru paula@birc.au.dk 9/12www.birc.au.dk Restricting on regular expressions R = X = Y = Restricted likelihood -> distribution Restricted prediction Space & time consumption a: 0.3 b: 0.7 a: 0.8 b: 0.2 a: 0.5 b: 0.5 0.9 0.1 0.4 0.6 1.0 0.1 0.9a b b a b b a
- 12. Paula Tataru paula@birc.au.dk 12/12www.birc.au.dk www.birc.au.dk More information So we use the power of computers together with our knowledge of biology to answer biological questions. This is called Bioinformatics.