The Black Death was a devastating pandemic that originated in Asia and spread to Europe between 1346-1353, killing an estimated 75-200 million people. It was caused by the bacterium Yersinia pestis, which was often carried by fleas on rats and spread to humans. There were three main forms: bubonic plague caused swollen lymph nodes, pneumonic plague led to lung infection, and septicemic plague caused blood poisoning. In the absence of modern medicine, treatments were ineffective and mortality rates were extremely high. The Black Death had profound social and economic impacts on medieval Europe. While rare, plague still occurs today but modern sanitation and antibiotics have controlled its spread.