Brigitta peterson vm1_3ruhm_

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This study examined heart tissue samples from 16 dogs and 13 cats to investigate whether chlamydial infections are correlated with coronary arteriosclerotic lesions in canines and felines. Real-time PCR, microarray, and immunohistochemistry testing found chlamydia in some samples but no obvious connection between spontaneous lesions and infections. While arteriosclerosis was present in all cat hearts, only two dogs showed atherosclerosis, and chlamydia was not correlated with these solely atherosclerotic cases. More sample testing is needed to make definitive conclusions about links between chlamydial infections and canine or feline coronary arteriosclerosis.

Education

CHLAMYDIA IN CANINE
OR FELINE CORONARY
ARTERIOSCLEROTIC
LESIONS

Brigitta Peterson VM I, 3. rühm 2011

Introduction
 The study was conducted by Croatian and
Swiss veterinarians
 Hardening of the vessels is generally
denominated as "arteriosclerosis"
 The aim of the present study was to examine
whether there is a correlation between canine
and feline spontaneous atherosclerosis or
arteriosclerosis and the presence of
Chlamydia.

Background
 The purpose of this study was to try to
establish a correlation between any type of
arteriosclerotic changes in hearts of dogs and
cats and chlamydial infection.
 Numerous reports linking Chlamydia infection
to human coronary atherosclerosis
 Heart tissue samples of 16 dogs and 13 cats
were examined

Methods
 Real-time PCR

 ArrayTube Microarray

 Immunohistochemistry.

Results
 Of dogs, 15 animals had recorded lesions only
in the heart (n = 14) or aorta (n = 1). Only two
cases had atherosclerotic lesions, while the
remaining lesions were classified as
arteriosclerosis (n = 14).
 Arteriosclerosis was present in all 13 cat
hearts. Of cats, seven animals expressed
arteriosclerotic lesions only in the heart.

Discussion
 The aim of this study was to correlate
spontaneous atherosclerotic and
arteriosclerotic lesions in heart tissues of dogs
and cats with the presence of Chlamydia.
 Regarding solely atherosclerotic cases, no
connection was established between these
lesions and chlamydial infections.

Conclusions
 This investigation indicates that there is no
obvious correlation between spontaneous
coronary arteriosclerotic lesions of dogs and
cats and chlamydial infections.
 To make final conclusions, more samples of
canine and feline atherosclerotic lesions
should be investigated.

References
 Ivan C Sostaric-Zuckermann1, Nicole
Borel, Carmen Kaiser, Zeljko
Grabarevic1, Andreas Pospischil . 2011.
„Chlamydia in canine or feline coronary
arteriosclerotic lesions“ Available at
http://www.biomedcentral.com/1756-
0500/4/350

The study examined heart tissue samples from 16 dogs and 13 cats for the presence of Chlamydia and correlations with arteriosclerotic lesions. Real-time PCR, microarray, and immunohistochemistry testing found Chlamydia in some samples but no obvious connection between Chlamydia infections and spontaneous coronary arteriosclerotic lesions in dogs and cats. More samples would need to be investigated to make final conclusions about potential links between Chlamydia and arteriosclerosis in these animals.

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Brigitta peterson vm1_3ruhm_

1. CHLAMYDIA IN CANINE OR FELINE CORONARY ARTERIOSCLEROTIC LESIONS Brigitta Peterson VM I, 3. rühm 2011

2. Introduction  The study was conducted by Croatian and Swiss veterinarians  Hardening of the vessels is generally denominated as "arteriosclerosis"  The aim of the present study was to examine whether there is a correlation between canine and feline spontaneous atherosclerosis or arteriosclerosis and the presence of Chlamydia.

3. Background  The purpose of this study was to try to establish a correlation between any type of arteriosclerotic changes in hearts of dogs and cats and chlamydial infection.  Numerous reports linking Chlamydia infection to human coronary atherosclerosis  Heart tissue samples of 16 dogs and 13 cats were examined

4. Methods  Real-time PCR  ArrayTube Microarray  Immunohistochemistry.

5. Results  Of dogs, 15 animals had recorded lesions only in the heart (n = 14) or aorta (n = 1). Only two cases had atherosclerotic lesions, while the remaining lesions were classified as arteriosclerosis (n = 14).  Arteriosclerosis was present in all 13 cat hearts. Of cats, seven animals expressed arteriosclerotic lesions only in the heart.

6. Discussion  The aim of this study was to correlate spontaneous atherosclerotic and arteriosclerotic lesions in heart tissues of dogs and cats with the presence of Chlamydia.  Regarding solely atherosclerotic cases, no connection was established between these lesions and chlamydial infections.

7. Conclusions  This investigation indicates that there is no obvious correlation between spontaneous coronary arteriosclerotic lesions of dogs and cats and chlamydial infections.  To make final conclusions, more samples of canine and feline atherosclerotic lesions should be investigated.

8. References  Ivan C Sostaric-Zuckermann1, Nicole Borel, Carmen Kaiser, Zeljko Grabarevic1, Andreas Pospischil . 2011. „Chlamydia in canine or feline coronary arteriosclerotic lesions“ Available at http://www.biomedcentral.com/1756- 0500/4/350

9. Thank you for your attention!

�ݺ�ߣ

Brigitta peterson vm1_3ruhm_

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