This document outlines key concepts related to estimation and confidence intervals. It defines point estimates as single values used to estimate population parameters and interval estimates as ranges of values within which the population parameter is expected to occur. Confidence intervals provide an interval range based on sample observations within which the population parameter is expected to fall at a specified confidence level, such as 95% or 99%. The document discusses how to construct confidence intervals for the population mean when the population standard deviation is known or unknown.
Here are the key steps to construct confidence intervals in R:
1. Generate sample data from a population distribution. For example, to generate a random sample of size 30 from a normal distribution with mean 100 and standard deviation 15:
x <- rnorm(30, 100, 15)
2. Calculate the sample mean and standard deviation:
mean(x)
sd(x)
3. Determine the appropriate t-statistic value based on the confidence level and degrees of freedom (n-1). For example, for a 95% CI with 29 df, the t-stat is 2.045:
qt(0.975, 29)
4. Calculate the confidence interval limits as:
This document outlines key concepts related to constructing confidence intervals for estimating population means and proportions. It discusses how to calculate confidence intervals when the population standard deviation is known or unknown. Specifically, it provides the formulas and assumptions for constructing confidence intervals for a population mean using the normal and t-distributions. It also outlines how to calculate confidence intervals for a population proportion using the normal approximation. Examples are provided to demonstrate how to construct 95% confidence intervals for a mean and proportion based on sample data.
Inferential statistics are used to draw conclusions about populations based on samples. The two primary inferential methods are estimation and hypothesis testing. Estimation involves using sample statistics to estimate unknown population parameters, such as means or proportions. Interval estimation provides a range of plausible values for the population parameter based on the sample data and a level of confidence, such as a 95% confidence interval. The width of the confidence interval depends on factors like the sample size, standard deviation, and desired confidence level.
This document discusses inferential statistics and confidence intervals. It introduces confidence intervals for a population mean using the t-distribution when the sample size is small (less than 30). When the population variance is known, the z-distribution can be used. It provides examples of how to calculate 95% and 99% confidence intervals for a population mean using the t-distribution and normal distribution. Formulas for the standard error and reliability coefficients are also presented.
This document discusses statistical confidence interval estimation. It covers:
1) Confidence interval estimation for the mean when the population standard deviation is known and unknown.
2) Confidence interval estimation for the proportion.
3) Factors that affect confidence interval width like data variation, sample size, and confidence level.
4) How to estimate sample sizes needed to estimate a population mean or proportion within a given level of precision and confidence.
1. The standard deviation is a measure of how spread out numbers are from the average value.
2. It is calculated by taking the square root of the variance, which is the average of the squared differences from the mean.
3. When only a sample of data is available rather than the entire population, the sample standard deviation is estimated using N-1 in the denominator rather than N to reduce bias, though some bias still remains for small samples.
1) The document provides information about statistics homework help and tutoring services offered by Homework Guru. It discusses various types of statistics help available, including online tutoring, homework help, and exam preparation.
2) Key aspects of their tutoring services are highlighted, including the qualifications of tutors, availability, and interactive online classrooms. Confidence intervals and how to calculate them are also explained in detail.
3) Examples are given to demonstrate how to calculate 95% and 99% confidence intervals for a population mean when the population standard deviation is known or unknown. Interval estimation procedures and when to use z-tests or t-tests are summarized.
This document discusses various methods for constructing confidence intervals to estimate population parameters using sample statistics. It covers confidence interval estimation for the mean when the population standard deviation is known and unknown, estimation for the proportion, and addresses situations involving finite populations. Factors that influence confidence interval width and formulas for determining necessary sample sizes are also presented. Examples are provided to illustrate how to set up confidence intervals and calculate required sample sizes.
The document discusses estimation and confidence intervals. It explains the central limit theorem, which states that sample means will approximate a normal distribution as long as sample sizes are sufficiently large. This allows constructing confidence intervals for a population mean using z-scores. The document provides formulas for calculating confidence intervals using point estimates from sample data and outlines how to interpret the resulting confidence intervals. It notes that when the population standard deviation is unknown, a t-distribution can be used if sample sizes are large enough.
This document discusses statistical estimation and confidence intervals. It begins with an overview of the central limit theorem, which states that as sample size increases, the sampling distribution of the sample means will approximate a normal distribution. It then covers how to construct confidence intervals to estimate population parameters like the mean and proportion when the population standard deviation is both known and unknown. The document explains how the t-distribution is used when the population standard deviation is unknown and the sample size is small. It provides examples of how to calculate confidence intervals and determine sample sizes needed based on the central limit theorem.
Confidence Intervals in the Life Sciences PresentationNamesS.docxmaxinesmith73660
油
Confidence Intervals in the Life Sciences Presentation
Names
Statistics for the Life Sciences STAT/167
Date
Fahad M. Gohar M.S.A.S
1
Conservation Biology of Bears
Normal Distribution
Standard normal distribution
Confidence Interval
Population Mean
Population Variance
Confidence Level
Point Estimate
Critical Value
Margin of Error
Welcome to the presentation on Confidence Intervals of Conservation Biology on Bears.
The team will define normal distribution and use an example of variables why this is important. A standard and normal distribution is discussed as well as the difference between standard and other normal distributions. Confidence interval will be defined and how it is used in Conservation Biology and Bears. We will learn how a confidence interval helps researchers estimate of population mean and population variance. The presenters defined a point estimate and try to explain how a point estimate found from a confidence interval. Confidence level is defined and a short explanation of confidence level is related to the confidence interval. Lastly, a critical value and margin of error are explained with examples from the Statdisk.
2
Normal Distribution
A normal distribution is one which has the mean, median, and mode are the same and the standard deviations are apart from the mean in the probabilities that go with the empirical rule. Not all data has the measures of central tendency, since some data sets may not have one unique value which occurs more than once. But every data set has a mean and median. The mean is only good with interval and ratio data, while the median can be used with interval, ratio and ordinal data. Mean is used when they're a lot of outliers, and median is used when there are few.
The normal distribution is continuous, and has only two parameters - mean and variance. The mean can be any positive number and variance can be any positive number (can't be negative - the mean and variance), so there are an infinite number of normal distributions. You want your data to represent the population distribution because when you make claims from the distribution of the sample you took, you want it to represent the whole entire population.
Some examples in the business world: Some industries which use normal distributions are pharmaceutical companies. They model the average blood pressure through normal distributions, and can make medicine which will help majority of the people with high blood pressure. A company can also model its average time to create something using the normal distribution. Several statistics can be calculated with the normal distribution, and hypothesis tests can be done with the normal distribution which models the average time.
Our chosen life science is BEARS. The age of the bears can be modeled by normal distributions and it is important to monitor since that tells us the average age of the bear, and can tell us a lot about the population. If the mean is high and the standard deviatio.
This document provides an overview of key concepts related to the normal distribution, sampling distributions, estimation, and hypothesis testing. It defines important terms like the normal curve, z-scores, sampling distributions, point and interval estimates, and the steps of hypothesis testing including stating hypotheses, collecting data, and determining whether to reject the null hypothesis. It also reviews concepts like the central limit theorem, standard error, bias, confidence intervals, types of errors in hypothesis testing, and factors that influence test statistics.
We review important concepts from Chapters 1-5 of the statistics textbook.
1) Descriptive statistics summarize sample data, while inferential statistics make predictions about populations from samples.
2) Variables can be categorical (nominal, ordinal) or quantitative (continuous, discrete), which affects analysis methods.
3) Random sampling and random assignment in experiments reduce bias to obtain reliable data.
4) Probability distributions, the normal distribution, and the Central Limit Theorem are important concepts for statistical inference.
Please Subscribe to this Channel for more solutions and lectures
http://www.youtube.com/onlineteaching
Chapter 7: Estimating Parameters and Determining Sample Sizes
7.3: Estimating a Population Standard Deviation or Variance
Please Subscribe to this Channel for more solutions and lectures
http://www.youtube.com/onlineteaching
Chapter 7: Estimating Parameters and Determining Sample Sizes
7.3: Estimating a Population Standard Deviation or Variance
This document discusses estimating parameters and determining sample sizes from populations. It covers estimating population proportions, means, standard deviations, and variances. For each parameter, it describes how to construct confidence intervals and determine the necessary sample size. Formulas are provided for margin of error, t-scores, z-scores and the chi-square distribution, which is used for estimating variances and standard deviations. Examples show how to apply the concepts to find confidence intervals and critical values for specific population problems.
This document discusses key concepts in statistical estimation including:
- Estimation involves using sample data to infer properties of the population by calculating point estimates and interval estimates.
- A point estimate is a single value that estimates an unknown population parameter, while an interval estimate provides a range of plausible values for the parameter.
- A confidence interval gives the probability that the interval calculated from the sample data contains the true population parameter. Common confidence intervals are 95% confidence intervals.
- Formulas for confidence intervals depend on whether the population standard deviation is known or unknown, and the sample size.
The document discusses confidence intervals, which provide a range of values that are likely to contain an unknown population parameter based on a sample statistic. It covers how to construct confidence intervals for a population mean when the population standard deviation is known and unknown, using the t-distribution when the standard deviation is unknown. The document also discusses how confidence intervals provide more information than point estimates and how their width and confidence level are determined.
1) The sample shows the mean weight of men is 172.55 lbs with a standard deviation of 26 lbs.
2) A 95% confidence interval for the population mean weight is estimated to be between 164.49 lbs and 180.61 lbs.
3) This suggests that the outdated estimate of 166.3 lbs used for safety capacities is likely an underestimate, and updating to the point estimate of 172.55 lbs could help prevent overloading issues.
Ch3_Statistical Analysis and Random Error Estimation.pdfVamshi962726
油
Here are the steps to solve this example:
(a) Compute the sample statistics:
Mean (x) = (裡xi)/n = (56.13)/10 = 5.613 cm
Standard deviation (s) = [(裡(xi - x)2)/(n-1)] = 0.6266 cm
(b) The interval over which 95% of measurements should lie is:
x 賊 t0.025,9s = 5.613 賊 2.262(0.6266) = 5.613 賊 1.417 cm
(c) The estimated true mean value at 95% probability is:
亮x = x
This document discusses statistical estimation and provides information about objectives, outline, statistical inference, estimation types (point and interval), confidence intervals, and sample size calculation. The key points are:
- The objectives are to describe statistical inference, differentiate between point and interval estimation, compute confidence intervals, and describe sample size calculation methods.
- Point estimation provides a single value to estimate a population parameter, while interval estimation provides a range of values that the population parameter is likely to fall within.
- Confidence intervals account for sample to sample variation and give a measure of precision for estimates. Common confidence levels are 90%, 95%, and 99%.
This document discusses key concepts related to normal distributions and z-scores. It provides examples of how to calculate z-scores based on a data set's mean and standard deviation. It also shows how to use z-score values and the normal distribution table to determine the probability that a random value will fall within a given range. The key points are that z-scores indicate how many standard deviations a value is from the mean, and the normal distribution allows converting between z-scores and probabilities.
This document discusses confidence intervals, which are interval estimates of population parameters that indicate the reliability of sample estimates. The document defines confidence intervals and explains how they are constructed. It also discusses point estimates versus interval estimates and describes how to calculate confidence intervals for means, proportions, and when the population standard deviation is unknown using the t-distribution. Examples are provided to illustrate how to construct confidence intervals in different situations.
This document discusses estimating population parameters such as proportions, means, and standard deviations from sample data. It covers how to calculate confidence intervals for a population proportion based on a sample proportion. The key steps are to determine the sample proportion, calculate the margin of error using the sample size and a critical z-value, and use these to estimate the confidence interval. An example is provided to demonstrate calculating the confidence interval for a population proportion based on survey data. The summary accurately conveys the main topic and methods discussed in the document in under 3 sentences.
Stability of Dosage Forms as per ICH GuidelinesKHUSHAL CHAVAN
油
This presentation covers the stability testing of pharmaceutical dosage forms according to ICH guidelines (Q1A-Q1F). It explains the definition of stability, various testing protocols, storage conditions, and evaluation criteria required for regulatory submissions. Key topics include stress testing, container closure systems, stability commitment, and photostability testing. The guidelines ensure that pharmaceutical products maintain their identity, purity, strength, and efficacy throughout their shelf life. This resource is valuable for pharmaceutical professionals, researchers, and regulatory experts.
Solubilization in Pharmaceutical Sciences: Concepts, Mechanisms & Enhancement...KHUSHAL CHAVAN
油
This presentation provides an in-depth understanding of solubilization and its critical role in pharmaceutical formulations. It covers:
Definition & Mechanisms of Solubilization
Role of surfactants, micelles, and bile salts in drug solubility
Factors affecting solubilization (pH, polarity, particle size, temperature, etc.)
Methods to enhance drug solubility (Buffers, Co-solvents, Surfactants, Complexation, Solid Dispersions)
Advanced approaches (Polymorphism, Salt Formation, Co-crystallization, Prodrugs)
This resource is valuable for pharmaceutical scientists, formulation experts, regulatory professionals, and students interested in improving drug solubility and bioavailability.
More Related Content
Similar to Chapter 7 note Estimation.ppt biostatics (20)
1) The document provides information about statistics homework help and tutoring services offered by Homework Guru. It discusses various types of statistics help available, including online tutoring, homework help, and exam preparation.
2) Key aspects of their tutoring services are highlighted, including the qualifications of tutors, availability, and interactive online classrooms. Confidence intervals and how to calculate them are also explained in detail.
3) Examples are given to demonstrate how to calculate 95% and 99% confidence intervals for a population mean when the population standard deviation is known or unknown. Interval estimation procedures and when to use z-tests or t-tests are summarized.
This document discusses various methods for constructing confidence intervals to estimate population parameters using sample statistics. It covers confidence interval estimation for the mean when the population standard deviation is known and unknown, estimation for the proportion, and addresses situations involving finite populations. Factors that influence confidence interval width and formulas for determining necessary sample sizes are also presented. Examples are provided to illustrate how to set up confidence intervals and calculate required sample sizes.
The document discusses estimation and confidence intervals. It explains the central limit theorem, which states that sample means will approximate a normal distribution as long as sample sizes are sufficiently large. This allows constructing confidence intervals for a population mean using z-scores. The document provides formulas for calculating confidence intervals using point estimates from sample data and outlines how to interpret the resulting confidence intervals. It notes that when the population standard deviation is unknown, a t-distribution can be used if sample sizes are large enough.
This document discusses statistical estimation and confidence intervals. It begins with an overview of the central limit theorem, which states that as sample size increases, the sampling distribution of the sample means will approximate a normal distribution. It then covers how to construct confidence intervals to estimate population parameters like the mean and proportion when the population standard deviation is both known and unknown. The document explains how the t-distribution is used when the population standard deviation is unknown and the sample size is small. It provides examples of how to calculate confidence intervals and determine sample sizes needed based on the central limit theorem.
Confidence Intervals in the Life Sciences PresentationNamesS.docxmaxinesmith73660
油
Confidence Intervals in the Life Sciences Presentation
Names
Statistics for the Life Sciences STAT/167
Date
Fahad M. Gohar M.S.A.S
1
Conservation Biology of Bears
Normal Distribution
Standard normal distribution
Confidence Interval
Population Mean
Population Variance
Confidence Level
Point Estimate
Critical Value
Margin of Error
Welcome to the presentation on Confidence Intervals of Conservation Biology on Bears.
The team will define normal distribution and use an example of variables why this is important. A standard and normal distribution is discussed as well as the difference between standard and other normal distributions. Confidence interval will be defined and how it is used in Conservation Biology and Bears. We will learn how a confidence interval helps researchers estimate of population mean and population variance. The presenters defined a point estimate and try to explain how a point estimate found from a confidence interval. Confidence level is defined and a short explanation of confidence level is related to the confidence interval. Lastly, a critical value and margin of error are explained with examples from the Statdisk.
2
Normal Distribution
A normal distribution is one which has the mean, median, and mode are the same and the standard deviations are apart from the mean in the probabilities that go with the empirical rule. Not all data has the measures of central tendency, since some data sets may not have one unique value which occurs more than once. But every data set has a mean and median. The mean is only good with interval and ratio data, while the median can be used with interval, ratio and ordinal data. Mean is used when they're a lot of outliers, and median is used when there are few.
The normal distribution is continuous, and has only two parameters - mean and variance. The mean can be any positive number and variance can be any positive number (can't be negative - the mean and variance), so there are an infinite number of normal distributions. You want your data to represent the population distribution because when you make claims from the distribution of the sample you took, you want it to represent the whole entire population.
Some examples in the business world: Some industries which use normal distributions are pharmaceutical companies. They model the average blood pressure through normal distributions, and can make medicine which will help majority of the people with high blood pressure. A company can also model its average time to create something using the normal distribution. Several statistics can be calculated with the normal distribution, and hypothesis tests can be done with the normal distribution which models the average time.
Our chosen life science is BEARS. The age of the bears can be modeled by normal distributions and it is important to monitor since that tells us the average age of the bear, and can tell us a lot about the population. If the mean is high and the standard deviatio.
This document provides an overview of key concepts related to the normal distribution, sampling distributions, estimation, and hypothesis testing. It defines important terms like the normal curve, z-scores, sampling distributions, point and interval estimates, and the steps of hypothesis testing including stating hypotheses, collecting data, and determining whether to reject the null hypothesis. It also reviews concepts like the central limit theorem, standard error, bias, confidence intervals, types of errors in hypothesis testing, and factors that influence test statistics.
We review important concepts from Chapters 1-5 of the statistics textbook.
1) Descriptive statistics summarize sample data, while inferential statistics make predictions about populations from samples.
2) Variables can be categorical (nominal, ordinal) or quantitative (continuous, discrete), which affects analysis methods.
3) Random sampling and random assignment in experiments reduce bias to obtain reliable data.
4) Probability distributions, the normal distribution, and the Central Limit Theorem are important concepts for statistical inference.
Please Subscribe to this Channel for more solutions and lectures
http://www.youtube.com/onlineteaching
Chapter 7: Estimating Parameters and Determining Sample Sizes
7.3: Estimating a Population Standard Deviation or Variance
Please Subscribe to this Channel for more solutions and lectures
http://www.youtube.com/onlineteaching
Chapter 7: Estimating Parameters and Determining Sample Sizes
7.3: Estimating a Population Standard Deviation or Variance
This document discusses estimating parameters and determining sample sizes from populations. It covers estimating population proportions, means, standard deviations, and variances. For each parameter, it describes how to construct confidence intervals and determine the necessary sample size. Formulas are provided for margin of error, t-scores, z-scores and the chi-square distribution, which is used for estimating variances and standard deviations. Examples show how to apply the concepts to find confidence intervals and critical values for specific population problems.
This document discusses key concepts in statistical estimation including:
- Estimation involves using sample data to infer properties of the population by calculating point estimates and interval estimates.
- A point estimate is a single value that estimates an unknown population parameter, while an interval estimate provides a range of plausible values for the parameter.
- A confidence interval gives the probability that the interval calculated from the sample data contains the true population parameter. Common confidence intervals are 95% confidence intervals.
- Formulas for confidence intervals depend on whether the population standard deviation is known or unknown, and the sample size.
The document discusses confidence intervals, which provide a range of values that are likely to contain an unknown population parameter based on a sample statistic. It covers how to construct confidence intervals for a population mean when the population standard deviation is known and unknown, using the t-distribution when the standard deviation is unknown. The document also discusses how confidence intervals provide more information than point estimates and how their width and confidence level are determined.
1) The sample shows the mean weight of men is 172.55 lbs with a standard deviation of 26 lbs.
2) A 95% confidence interval for the population mean weight is estimated to be between 164.49 lbs and 180.61 lbs.
3) This suggests that the outdated estimate of 166.3 lbs used for safety capacities is likely an underestimate, and updating to the point estimate of 172.55 lbs could help prevent overloading issues.
Ch3_Statistical Analysis and Random Error Estimation.pdfVamshi962726
油
Here are the steps to solve this example:
(a) Compute the sample statistics:
Mean (x) = (裡xi)/n = (56.13)/10 = 5.613 cm
Standard deviation (s) = [(裡(xi - x)2)/(n-1)] = 0.6266 cm
(b) The interval over which 95% of measurements should lie is:
x 賊 t0.025,9s = 5.613 賊 2.262(0.6266) = 5.613 賊 1.417 cm
(c) The estimated true mean value at 95% probability is:
亮x = x
This document discusses statistical estimation and provides information about objectives, outline, statistical inference, estimation types (point and interval), confidence intervals, and sample size calculation. The key points are:
- The objectives are to describe statistical inference, differentiate between point and interval estimation, compute confidence intervals, and describe sample size calculation methods.
- Point estimation provides a single value to estimate a population parameter, while interval estimation provides a range of values that the population parameter is likely to fall within.
- Confidence intervals account for sample to sample variation and give a measure of precision for estimates. Common confidence levels are 90%, 95%, and 99%.
This document discusses key concepts related to normal distributions and z-scores. It provides examples of how to calculate z-scores based on a data set's mean and standard deviation. It also shows how to use z-score values and the normal distribution table to determine the probability that a random value will fall within a given range. The key points are that z-scores indicate how many standard deviations a value is from the mean, and the normal distribution allows converting between z-scores and probabilities.
This document discusses confidence intervals, which are interval estimates of population parameters that indicate the reliability of sample estimates. The document defines confidence intervals and explains how they are constructed. It also discusses point estimates versus interval estimates and describes how to calculate confidence intervals for means, proportions, and when the population standard deviation is unknown using the t-distribution. Examples are provided to illustrate how to construct confidence intervals in different situations.
This document discusses estimating population parameters such as proportions, means, and standard deviations from sample data. It covers how to calculate confidence intervals for a population proportion based on a sample proportion. The key steps are to determine the sample proportion, calculate the margin of error using the sample size and a critical z-value, and use these to estimate the confidence interval. An example is provided to demonstrate calculating the confidence interval for a population proportion based on survey data. The summary accurately conveys the main topic and methods discussed in the document in under 3 sentences.
Stability of Dosage Forms as per ICH GuidelinesKHUSHAL CHAVAN
油
This presentation covers the stability testing of pharmaceutical dosage forms according to ICH guidelines (Q1A-Q1F). It explains the definition of stability, various testing protocols, storage conditions, and evaluation criteria required for regulatory submissions. Key topics include stress testing, container closure systems, stability commitment, and photostability testing. The guidelines ensure that pharmaceutical products maintain their identity, purity, strength, and efficacy throughout their shelf life. This resource is valuable for pharmaceutical professionals, researchers, and regulatory experts.
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Role of surfactants, micelles, and bile salts in drug solubility
Factors affecting solubilization (pH, polarity, particle size, temperature, etc.)
Methods to enhance drug solubility (Buffers, Co-solvents, Surfactants, Complexation, Solid Dispersions)
Advanced approaches (Polymorphism, Salt Formation, Co-crystallization, Prodrugs)
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ECZEMA 3rd year notes with images .pptxAyesha Fatima
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If its not Itch Its not Eczema
Eczema is a group of medical conditions which causes inflammation and irritation to skin.
It is also called as Dermatitis
Eczema is an itchy consisting of ill defined erythremotous patches. The skin surface is usually scaly and As time progress, constant scratching leads to thickened lichenified skin.
Several classifications of eczemas are available based on Etiology, Pattern and chronicity.
According to aetiology Eczema are classified as:
Endogenous eczema: Where constitutional factors predispose the patient to developing an eczema.
Family history (maternal h/o eczema) is often present
Strong genetic predisposition (Filaggrin gene mutations are often present).
Filaggrin is responsible for maintaining moisture in skin (hence all AD patients have dry skin.
Immunilogical factor-Th-2 disease, Type I hypersensitivity (hence serum IgE high)
e.g., Seborrheic dermatitis, Statis dermatitis, Nummular dermatitis, Dyshidrotic Eczema
Exogenous eczema: Where external stimuli trigger development of eczema,
e.g., Irritant dermatitis, Allergic Dermatitis, Neurodermatitis,
Combined eczema: When a combination of constitutional factors and extrinsic triggers are responsible for the development of eczema
e.g., Atopic dermatitis
Extremes of Temperature
Irritants : Soaps, Detergents, Shower gels, Bubble baths and water
Stress
Infection either bacterial or viral,
Bacterial infections caused by Staphylococcus aureus and Streptococcus species.
Viral infections such as Herpes Simplex, Molluscum Contagiosum
Contact allergens
Inhaled allergens
Airborne allergens
Allergens include
Metals eg. Nickle, Cobalt
Neomycin, Topical ointment
Fragrance ingredients such as Balsam of Peru
Rubber compounds
Hair dyes for example p-Phenylediamine
Plants eg. Poison ivy .
Atopic Dermatitis : AD is a chronic, pruritic inflammatory skin disease characterized by itchy inflamed skin.
Allergic Dermatitis: A red itchy weepy reaction where the skin has come in contact with a substance That immune system recognizes as foreign substances.
Ex: Poison envy, Preservatives from creams and lotions.
Contact Irritant Dermatitis: A Localized reaction that include redness, itching and burning where the skin has come In contact with an allergen or with irritant such as acid, cleaning agent or chemical.
Dyshidrotic Eczema: Irritation of skin on the palms and soles by
clear deep blisters that itch and burn.
Clinical Features; Acute Eczema:- Acute eczema is characterized by an erythematous and edematous plaque, which is ill-defined and is surmounted by papules, vesicles, pustules and exudate that dries to form crusts. A subsiding eczematous plaque may be covered with scales.
Chronic Eczema:- Chronic eczema is characterized by lichenification, which is a triad of hyperpigmentation, thickening markings. The lesions are less exudative and more scaly. Flexural lesions may develop fissures.
Pruritus
Characteristic Rash
Chronic or repeatedly occurring symptoms.
2. 6-2
Types of estimators
Point Estimate
A single-valued estimate.
A single element chosen from a sampling distribution.
Conveys little information about the actual value of the
population parameter, about the accuracy of the
estimate.
Confidence Interval or Interval Estimate
An interval or range of values believed to include the
unknown population parameter.
Associated with the interval is a measure of the
confidence
confidence we have that the interval does indeed
contain the parameter of interest.
3. 6-3
1. Point Estimation
Definition:
A parameter is a numerical descriptive measure of a
population ( 亮 is an example of a parameter).
A statistic is a numerical descriptive measure of a
sample ( X is an example of a statistic).
To each sample statistic there corresponds a
population parameter.
We use X , S2
, S , p, etc. to estimate 亮, 2
, , P (or ),
etc.
4. 6-4
Sample statistics
(sample mean)
S2
( sample variance)
S (sample Standard
deviation)
P (sample proportion)
Population
parameter
亮 (population mean)
2
( population
variance)
(population
standard deviation)
P or (Population
proportion)
X
5. 6-5
Definition:
A point estimate of some population parameter O
is a single value of a sample statistic
Sampling Distribution of Means
one of the most fundamental concepts of statistical
inference, and it has remarkable properties.
Since it is a frequency distribution it has its own
mean and standard deviation
we shall use the notation for the standard
deviation of the distribution.
The standard deviation of the sampling
distribution of means is called the standard error
of the mean.
6. 6-6
Properties
1. The mean of the sampling distribution of means is
the same as the population mean, 亮 .
2. The SD of the sampling distribution of means is /
n .
3. The shape of the sampling distribution of means is
approximately a normal curve, regardless of the
shape of the population distribution and provided
n is large enough (Central limit theorem).
7. 6-7
Using Statistics
Confidence Interval for the Population Mean When
the Population Standard Deviation is Known
Confidence Intervals for When is Unknown - The
t Distribution
Large-Sample Confidence Intervals for the
Population Proportion p
Sample Size Determination
Confidence Intervals
8. 6-8
Consider the following statements:
x = 550
A single-valued estimate that conveys little information
about the actual value of the population mean.
We are 99% confident that is in the interval [449,551]
An interval estimate which locates the population mean
within a narrow interval, with a high level of confidence.
We are 90% confident that is in the interval [400,700]
An interval estimate which locates the population mean
within a broader interval, with a lower level of confidence.
9. 6-9
A confidence interval or interval estimate is a range or interval of
numbers believed to include an unknown population parameter.
Associated with the interval is a measure of the confidence we have
that the interval does indeed contain the parameter of interest.
A confidence interval or interval estimate
has two components:
A range or interval of values
An associated level of confidence
10. 6-10
If the population distribution is normal, the
sampling distribution of the mean is normal.
If the sample is sufficiently large, regardless of the
shape of the population distribution, the sampling
distribution is normal (Central Limit Theorem).
95
.
0
96
.
1
96
.
1
or
95
.
0
96
.
1
96
.
1
:
case
either
In
n
x
n
x
P
n
x
n
P
4
3
2
1
0
-1
-2
-3
-4
0.4
0.3
0.2
0.1
0.0
z
f(z)
Standard Normal Distribution: 95% Interval
12. 6-12
Approximately 95% of the intervals
around the sample mean can be
expected to include the actual value of the
population mean, . (When the sample
mean falls within the 95% interval around
the population mean.)
*5% of such intervals around the sample
mean can be expected not
not to include the
actual value of the population mean.
(When the sample mean falls outside the
95% interval around the population
mean.)
x x縁刻駈
x縁刻駈
n
x
96
.
1
0.4
0.3
0.2
0.1
0.0
x
f(x)
Sampling Distribution of the Mean
x
x
x
x
x
x
x
x
2.5%
95%
2.5%
196
.
n
196
.
n
x
x縁刻駈
x縁刻駈
*
*
p n u
95%
14. 6-14
A 95% confidence interval for when is known and sampling is
done from a normal population, or a large sample is used:
n
x
96
.
1
The quantity is often called the margin of error or the
sampling error.
n
96
.
1
For example, if:n = 25
鰹= 20
= 122
84
.
129
,
16
.
114
84
.
7
122
)
4
)(
96
.
1
(
122
25
20
96
.
1
122
96
.
1
n
x
A 95% confidence interval:
x
17. 6-17
When sampling from the same population, using a fixed sample size, the
higher the confidence level, the wider the confidence interval.
5
4
3
2
1
0
-1
-2
-3
-4
-5
0.4
0.3
0.2
0.1
0.0
Z
f(z)
Stand ard Nor m al Distribution
80% Confidence Interval:
x
n
128
.
5
4
3
2
1
0
-1
-2
-3
-4
-5
0.4
0.3
0.2
0.1
0.0
Z
f(z)
Stand ard Nor m al Distributi on
95% Confidence Interval:
x
n
196
.
18. 6-18
When sampling from the same population, using a fixed confidence
level, the larger the sample size, n, the narrower the confidence
interval.
0 .9
0 .8
0 .7
0 .6
0 .5
0 .4
0 .3
0 .2
0 .1
0 .0
x
f(x)
S am p ling D istrib utio n of the M e an
95% Confidence Interval: n = 40
0.4
0.3
0.2
0.1
0.0
x
f(x)
S am p ling D istrib utio n of the Me an
95% Confidence Interval: n = 20
0 .9
0 .8
0 .7
0 .6
0 .5
0 .4
0 .3
0 .2
0 .1
0 .0
x
f(x)
S am p ling D istrib utio n of the Me an
0 .4
0 .3
0 .2
0 .1
0 .0
x
f(x)
S am p ling D istrib utio n of the Me an
0 .9
0 .8
0 .7
0 .6
0 .5
0 .4
0 .3
0 .2
0 .1
0 .0
x
f(x)
S am p ling D istrib utio n of the Me an
0 .4
0 .3
0 .2
0 .1
0 .0
x
f(x)
S am p ling D istrib utio n of the Me an
19. 6-19
A physical therapist wished to estimate, with
99% confidence, the mean maximal strength
of a particular muscle in a certain group of
individuals. He assume that strength scores
are approximately normally distributed with
a variance of 144. A sample of 15 subjects
who participated in the experiment yielded a
mean of 84.3. What is 90% CI?
20. 6-20
Solution
留 = 0.01 Z留/2 = 2.58
Mean =84.3, n=15, =12
84.3 賊 2.58(12/ 15) 84.3 賊 8.0 (76.3, 92.3)
We are 99% confident that the population mean is
between 76.3 and 92.3.
21. 6-21
The t is a family of bell-shaped and symmetric
distributions, one for each number of degree of
freedom.
The expected value of t is 0.
For df > 2, the variance of t is df/(df-2). This is
greater than 1, but approaches 1 as the number
of degrees of freedom increases. The t is flatter
and has fatter tails than does the standard
normal.
The t distribution approaches a standard normal
as the number of degrees of freedom increases
If the population standard deviation, , is not known, replace
鰹with the sample standard deviation, s. If the population is
normal, the resulting statistic:
has a t distribution with (n - 1) degrees of freedom.
t
X
s
n
Standard normal
t, df = 20
t, df = 10
22. 6-22
A (1-)100% confidence interval for when is not known
(assuming a normally distributed population):
where is the value of the t distribution with n-1 degrees of
freedom that cuts off a tail area of to its right.
t
2
2
n
s
t
x
2
23. 6-23
df t0.100 t0.050 t0.025 t0.010 t0.005
--- ----- ----- ------ ------ ------
1 3.078 6.314 12.706 31.821 63.657
2 1.886 2.920 4.303 6.965 9.925
3 1.638 2.353 3.182 4.541 5.841
4 1.533 2.132 2.776 3.747 4.604
5 1.476 2.015 2.571 3.365 4.032
6 1.440 1.943 2.447 3.143 3.707
7 1.415 1.895 2.365 2.998 3.499
8 1.397 1.860 2.306 2.896 3.355
9 1.383 1.833 2.262 2.821 3.250
10 1.372 1.812 2.228 2.764 3.169
11 1.363 1.796 2.201 2.718 3.106
12 1.356 1.782 2.179 2.681 3.055
13 1.350 1.771 2.160 2.650 3.012
14 1.345 1.761 2.145 2.624 2.977
15 1.341 1.753 2.131 2.602 2.947
16 1.337 1.746 2.120 2.583 2.921
17 1.333 1.740 2.110 2.567 2.898
18 1.330 1.734 2.101 2.552 2.878
19 1.328 1.729 2.093 2.539 2.861
20 1.325 1.725 2.086 2.528 2.845
21 1.323 1.721 2.080 2.518 2.831
22 1.321 1.717 2.074 2.508 2.819
23 1.319 1.714 2.069 2.500 2.807
24 1.318 1.711 2.064 2.492 2.797
25 1.316 1.708 2.060 2.485 2.787
26 1.315 1.706 2.056 2.479 2.779
27 1.314 1.703 2.052 2.473 2.771
28 1.313 1.701 2.048 2.467 2.763
29 1.311 1.699 2.045 2.462 2.756
30 1.310 1.697 2.042 2.457 2.750
40 1.303 1.684 2.021 2.423 2.704
60 1.296 1.671 2.000 2.390 2.660
120 1.289 1.658 1.980 2.358 2.617
1.282 1.645 1.960 2.326 2.576
0
0 .4
0 .3
0 .2
0 .1
0 .0
t
f(t)
t D istrib utio n: d f=10
Area = 0.10
}
Area = 0.10
}
Area = 0.025
}
Area = 0.025
}
1.372
-1.372
2.228
-2.228
Whenever is not known (and the population is
assumed normal), the correct distribution to use is
the t distribution with n-1 degrees of freedom.
Note, however, that for large degrees of freedom,
the t distribution is approximated well by the Z
distribution.
24. 6-24
A study of hypoxemia during the immediate post-operative period reported
the fractions of ideal weight for 11 patients who became severely hypoxemic
during transfer to the recovery room. The mean is 1.51 and the standard
deviation is 0.33. Estimate the 95% C.I. for the population mean fraction of
ideal weight, where the population consists of hypoxemic patients similar to
those in the study (The data is normally distributed, use 留=0.05).
Solution
t留/2, n-1 / = t 0.025,10 = 2.2281
1 . 51 賊 2 . 2281(0 . 33/11)
1 . 51賊 0 . 221
(1 . 289 ,1 . 731 )
We are 95% sure that the 亮 (1 . 289 ,1 . 731 ) population mean lies
between 1.289 and 1.731
25. 6-25
Whenever is not known (and the population is
assumed normal), the correct distribution to use is
the t distribution with n-1 degrees of freedom.
Note, however, that for large degrees of freedom,
the t distribution is approximated well by the Z
distribution.
df t0.100 t0.050 t0.025 t0.010 t0.005
--- ----- ----- ------ ------ ------
1 3.078 6.314 12.706 31.821 63.657
. . . . . .
. . . . . .
. . . . . .
120 1.289 1.658 1.980 2.358 2.617
1.282 1.645 1.960 2.326 2.576
26. 6-26
n
s
z
x
2
:
for
interval
confidence
)100%
-
(1
sample
-
large
A
Example 6-3:
Example 6-3: An economist wants to estimate the average amount in checking accounts
at banks in a given region. A random sample of 100 accounts gives x-bar = $357.60
and s = $140.00. Give a 95% confidence interval for , the average amount in any
checking account at a bank in the given region.
x z
s
n
0 025
357.60 196
14000
100
357.60 27.44 33016,38504
.
.
.
. .
27. 6-27
The estimator of the population proportion, , is the sample proportion, . If the
sample size is large,
p p
p p p
p
pq
n
q = (1 - p)
p p
p n p n q
has an approximately normal distribution, with E( ) = and
V( ) = where . When the population proportion is unknown, use the
estimated value, , to estimate the standard deviation of .
For estimating , a sample is considered large enough when both an are greater
than 5.
,
29. 6-29
A marketing research firm wants to estimate the share that foreign companies
have in the American market for certain products. A random sample of 100
consumers is obtained, and it is found that 34 people in the sample are users
of foreign-made products; the rest are users of domestic products. Give a
95% confidence interval for the share of foreign products in this market.
. .
( . )( . )
. ( . )( . )
. .
. , .
p z
pq
n
2
0 34 196
0 34 0 66
100
0 34 196 0 04737
0 34 0 0928
0 2472 0 4328
Thus, the firm may be 95% confident that foreign manufacturers control
anywhere from 24.72% to 43.28% of the market.
30. 6-30
The width of a confidence interval can be reduced only at the
price of:
a lower level of confidence, or
a larger sample.
. .
( . )( . )
. ( . )( . )
. .
. , .
p z
pq
n
2
0 34 1645
0 34 0 66
100
0 34 1645 0 04737
0 34 0 07792
0 2621 0 4197
90% Confidence Interval
. .
( . )( . )
. ( . )( . )
. .
. , .
p z
pq
n
2
0 34 196
0 34 0 66
200
0 34 196 0 03350
0 34 0 0657
0 2743 0 4057
Sample Size, n = 200
Lower Level of Confidence Larger Sample Size
31. 6-31
How close do you want your sample estimate to be to the
unknown parameter? (What is the desired bound, B?)
What do you want the desired confidence level (1-) to be so
that the distance between your estimate and the parameter is
less than or equal to B?
What is your estimate of the variance (or standard deviation)
of the population in question?
Before determining the necessary sample size, three questions must
be answered:
n
2
z
x
:
for
Interval
Confidence
)
-
(1
A
:
example
For
32. 6-32
Standard error
of statistic
Sample size = n
Sample size = 2n
Standard error
of statistic
The sample size determines the bound of a statistic, since the standard
error of a statistic shrinks as the sample size increases:
34. 6-34
A marketing research firm wants to conduct a survey to estimate the average
amount spent on entertainment by each person visiting a popular resort. The
people who plan the survey would like to determine the average amount spent by
all people visiting the resort to within $120, with 95% confidence. From past
operation of the resort, an estimate of the population standard deviation is
s = $400. What is the minimum required sample size?
n
z
B
2
2 2
2
2 2
2
1 96 400
120
42 684 43
( . ) ( )
.
35. 6-35
The manufacturers of a sports car want to estimate the proportion of people in a
given income bracket who are interested in the model. The company wants to
know the population proportion, p, to within 0.01 with 99% confidence. Current
company records indicate that the proportion p may be around 0.25. What is the
minimum required sample size for this survey?
n
z pq
B
2
2
2
2
2
2 576 025 0 75
010
124.42 125
. ( . )( . )
.