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Childrens national hospital grand rounds final 020520

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This document discusses the experience of Martine Rothblatt, Ph.D. navigating her daughter's diagnosis and treatment of pediatric pulmonary hypertension. It outlines her journey working with experts in the field like Drs. Roger Ruckman and Robyn Barst. It then details Rothblatt's efforts to research the condition at Glaxo-Wellcome and her work with Sir John Vane. The document concludes by outlining Rothblatt's efforts to develop new treatment approaches like ex vivo lung perfusion and 3D bioprinting of lung scaffolds as potential solutions to the limited supply of donor lungs.

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Grand Rounds: A Parent’s Experience of Pediatric Pulmonary Hypertension Martine Rothblatt, Ph.D. Children’s National Medical Center
Childrens national hospital grand rounds final 020520
Roger Ruckman, MD, 1990s Head of Pediatric Cardiology at Children’s National Medical Breathe Curiosity
Robyn Barst, MD, 1990s – 2000s Head of Pediatric Pulmonary Hypertension Program at Columbia Presbyterian
Glaxo-Wellcome, Research Triangle Park, 1990s Question Authority
Sir John Vane, Nobel Laureate in Medicine, Founder of William Harvey Research Institute
Do Practically
Childrens national hospital grand rounds final 020520
Act Lovingly
With Sir Magdi and Lady Yacoub, World Record Holder for Heart and Lung Transplants, and My Partner Bina
EVLP – 1st Step in Manufacturing an Unlimited Supply of Lungs
Patient Heather Leverington Who Received Two of UT’s EVLP Lungs & Went On to Win Shotput Gold Medal in US Transplant Games
2nd Step: Allogeneic Recell in Bioreactors of Porcine Decell Lungs
Now Up to 500 Per Year – Available to Researchers (GMP Scaffolds & Partial Recell)
Step 3: Autologous Recell of 3D Printed Scaffolds
3D Lung Lobe Printing Time Reduced from 3 Months to 3 DaysAll From Bioink Being Optimized for Cellularization and, Uses Only Human Recombinant Collagen from Genetically Modified Tobacco Plants
Childrens national hospital grand rounds final 020520
Take Away Lessons •Breathe Curiosity: The Library •Question Authority: Impossible = I’m Possible •Do Practically: Parenteral > Inhaled > Oral •Manufacture Lungs By EVLP > Allogeneic Recell •Manufacture Lungs By Autologous 3D Bioprint •Act Lovingly –Make People Happier

More Related Content

Childrens national hospital grand rounds final 020520

  • 1. Grand Rounds: A Parent’s Experience of Pediatric Pulmonary Hypertension Martine Rothblatt, Ph.D. Children’s National Medical Center
  • 3. Roger Ruckman, MD, 1990s Head of Pediatric Cardiology at Children’s National Medical Breathe Curiosity
  • 4. Robyn Barst, MD, 1990s – 2000s Head of Pediatric Pulmonary Hypertension Program at Columbia Presbyterian
  • 5. Glaxo-Wellcome, Research Triangle Park, 1990s Question Authority
  • 6. Sir John Vane, Nobel Laureate in Medicine, Founder of William Harvey Research Institute
  • 10. With Sir Magdi and Lady Yacoub, World Record Holder for Heart and Lung Transplants, and My Partner Bina
  • 11. EVLP – 1st Step in Manufacturing an Unlimited Supply of Lungs
  • 12. Patient Heather Leverington Who Received Two of UT’s EVLP Lungs & Went On to Win Shotput Gold Medal in US Transplant Games
  • 13. 2nd Step: Allogeneic Recell in Bioreactors of Porcine Decell Lungs
  • 14. Now Up to 500 Per Year – Available to Researchers (GMP Scaffolds & Partial Recell)
  • 15. Step 3: Autologous Recell of 3D Printed Scaffolds
  • 16. 3D Lung Lobe Printing Time Reduced from 3 Months to 3 DaysAll From Bioink Being Optimized for Cellularization and, Uses Only Human Recombinant Collagen from Genetically Modified Tobacco Plants
  • 18. Take Away Lessons •Breathe Curiosity: The Library •Question Authority: Impossible = I’m Possible •Do Practically: Parenteral > Inhaled > Oral •Manufacture Lungs By EVLP > Allogeneic Recell •Manufacture Lungs By Autologous 3D Bioprint •Act Lovingly –Make People Happier