Chloride is absorbed in the small intestines through an exchange process with bicarbonate as sodium is absorbed. 99% of chloride is reabsorbed in the kidneys, mainly in the proximal tubule, loop of Henle, and collecting duct. Plasma chloride levels vary depending on plasma sodium and bicarbonate concentrations - chloride decreases with increases in sodium or bicarbonate, and increases with decreases in sodium or bicarbonate.
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Chlorine -minerals and trace elements
1. Clinical Biochemistry
SIMS-305
Dr. Ali Raza
Senior Lecturer
Centre for Human Genetics and Molecular Medicine (CHGMM),
Sindh Institute of Medical Sciences (SIMS), SIUT.
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3. CHLORINE
? Sodium Chloride (NaCl) in diet
Absorption:
a) Small intestines.
? The mechanism of chloride depend on an exchange
process with the HCO¨C3 , accompanying sodium
exchange for a hydrogen ion.
b) Renal:
(99 % )Cl¨Cis reabsorbed by renal tubules mainly in
? Proximal tubule (60-70%),
? loop of Henle (20-25%)
? Collecting duct (10-15%)
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4. CHLORINE Regulations
? Plasma levels of chloride vary with and to a great
extent depend on the
? plasma conc. of Na and
? plasma conc. of HCO¨C3.
? ¡ý Na associated with Cl¨C ¡ý
? ¡ü Na usually associated with Cl¨C ¡ü
? ¡ü HCO¨C3 associated with Cl¨C ¡ý
? ¡ý HCO¨C3 associated with Cl¨C ¡ü
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