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Clinical Biochemistry
SIMS-305
Dr. Ali Raza
Senior Lecturer
Centre for Human Genetics and Molecular Medicine (CHGMM),
Sindh Institute of Medical Sciences (SIMS), SIUT.
1
CHLORINE
2
CHLORINE
? Sodium Chloride (NaCl) in diet
Absorption:
a) Small intestines.
? The mechanism of chloride depend on an exchange
process with the HCO¨C3 , accompanying sodium
exchange for a hydrogen ion.
b) Renal:
(99 % )Cl¨Cis reabsorbed by renal tubules mainly in
? Proximal tubule (60-70%),
? loop of Henle (20-25%)
? Collecting duct (10-15%)
3
CHLORINE Regulations
? Plasma levels of chloride vary with and to a great
extent depend on the
? plasma conc. of Na and
? plasma conc. of HCO¨C3.
? ¡ý Na associated with Cl¨C ¡ý
? ¡ü Na usually associated with Cl¨C ¡ü
? ¡ü HCO¨C3 associated with Cl¨C ¡ý
? ¡ý HCO¨C3 associated with Cl¨C ¡ü
4

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  • 1. Clinical Biochemistry SIMS-305 Dr. Ali Raza Senior Lecturer Centre for Human Genetics and Molecular Medicine (CHGMM), Sindh Institute of Medical Sciences (SIMS), SIUT. 1
  • 3. CHLORINE ? Sodium Chloride (NaCl) in diet Absorption: a) Small intestines. ? The mechanism of chloride depend on an exchange process with the HCO¨C3 , accompanying sodium exchange for a hydrogen ion. b) Renal: (99 % )Cl¨Cis reabsorbed by renal tubules mainly in ? Proximal tubule (60-70%), ? loop of Henle (20-25%) ? Collecting duct (10-15%) 3
  • 4. CHLORINE Regulations ? Plasma levels of chloride vary with and to a great extent depend on the ? plasma conc. of Na and ? plasma conc. of HCO¨C3. ? ¡ý Na associated with Cl¨C ¡ý ? ¡ü Na usually associated with Cl¨C ¡ü ? ¡ü HCO¨C3 associated with Cl¨C ¡ý ? ¡ý HCO¨C3 associated with Cl¨C ¡ü 4