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Clinical research (literature, protocol elements)

M
Mohamed Fahmy Dehim

This document provides an overview of clinical research basics and medical literature. It discusses the importance of conducting literature reviews to avoid duplicating previous work and inform the research methodology. It describes the differences between journals, textbooks, and databases. Several common medical databases and research engines are listed, including PubMed, Google Scholar, Web of Science, Scopus, and Cochrane. PubMed is described in more detail, outlining how to access and search it using keywords, filters, Boolean operators, and truncation. Steps for developing a strong research proposal are also outlined.

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1 Clinical Research Basics Mohamed Fahmy Doheim M.B.B.Ch Candidate
Previous Session 1- Introduction Medical Research Types! Science? Research? Why do research?
Previous Session
Medical Literature : What, where and how?
What? Medical literature is the scientific literature of medicine: articles in journals and texts in books devoted to the field of medicine
6 Literature review It prevents the duplication of work that has been done before. It helps the researchers to find out what others have found and reported on the problem. It helps the researcher to become more familiar with the various types of methodology that could be used in the study. It should provide convincing arguments why this particular research project is needed.
Whats the difference? Journals ( Peer reviewed vs. not?) Text books Databases Publishers?
Common databases/ Research engines PubMed (website) from Medline! Google scholar Web of science (ISI) (Via EKB) Scopus (Via EKB) Embase ( No free access) Cochrane WHO Global Health Library (GHL)
PubMed Free resource developed and maintained by the National Center for Biotechnology Information (NCBI), at the U.S. National Library of Medicine (NLM), located at the National Institutes of Health (NIH). More than 5,400 worldwide journals in 60 languages. Covers 1947 to the present with some older material.
PubMed How to open PubMed? In your browser, type http://www.ncbi.nlm.nih.gov/pubmed
PubMed interface
Searching using Topic keywords
PubMed filters
Exporting items from PubMed
The abstract page
Boolean operators George Boole (1815 1864) was an English mathematician and philosopher. Invented Boolean logic which is the basis of modern digital computers. -AND -OR -NOT
AND
OR
NOT
TRUNCTION Truncation is a searchable shortened form of a word. Example: adolescen* will include adolescence adolescent adolescents, etc
Example We seach about Articles which mention The safety and efficacy of the combination of daclatasvir, asunaprevir, and beclabuvir in the treatment of chronic hepatitis C virus (Daclatasvir OR BMS-790052 OR Daklinza OR DCV) AND (Asunaprevir OR BMS-650032 OR Sunvepra OR ASV) AND (Beclabuvir OR BMS-791325 OR BCV).
Try yourself We want to know the effects of eicosapentaenoic acid (EPA) in depression. What's your proposed search strategy?
23 Steps of developing a research proposal Title of the research Background information and statement of the research problem (scientific justification for the study) Research objectives Research hypothesis Methodology Work plan Plan for utilization and dissemination of research results References Budget preparation Annexes
Clinical research (literature, protocol elements)

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Clinical research (literature, protocol elements)

  • 1. 1 Clinical Research Basics Mohamed Fahmy Doheim M.B.B.Ch Candidate
  • 2. Previous Session 1- Introduction Medical Research Types! Science? Research? Why do research?
  • 4. Medical Literature : What, where and how?
  • 5. What? Medical literature is the scientific literature of medicine: articles in journals and texts in books devoted to the field of medicine
  • 6. 6 Literature review It prevents the duplication of work that has been done before. It helps the researchers to find out what others have found and reported on the problem. It helps the researcher to become more familiar with the various types of methodology that could be used in the study. It should provide convincing arguments why this particular research project is needed.
  • 7. Whats the difference? Journals ( Peer reviewed vs. not?) Text books Databases Publishers?
  • 8. Common databases/ Research engines PubMed (website) from Medline! Google scholar Web of science (ISI) (Via EKB) Scopus (Via EKB) Embase ( No free access) Cochrane WHO Global Health Library (GHL)
  • 9. PubMed Free resource developed and maintained by the National Center for Biotechnology Information (NCBI), at the U.S. National Library of Medicine (NLM), located at the National Institutes of Health (NIH). More than 5,400 worldwide journals in 60 languages. Covers 1947 to the present with some older material.
  • 10. PubMed How to open PubMed? In your browser, type http://www.ncbi.nlm.nih.gov/pubmed
  • 16. Boolean operators George Boole (1815 1864) was an English mathematician and philosopher. Invented Boolean logic which is the basis of modern digital computers. -AND -OR -NOT
  • 17. AND
  • 18. OR
  • 19. NOT
  • 20. TRUNCTION Truncation is a searchable shortened form of a word. Example: adolescen* will include adolescence adolescent adolescents, etc
  • 21. Example We seach about Articles which mention The safety and efficacy of the combination of daclatasvir, asunaprevir, and beclabuvir in the treatment of chronic hepatitis C virus (Daclatasvir OR BMS-790052 OR Daklinza OR DCV) AND (Asunaprevir OR BMS-650032 OR Sunvepra OR ASV) AND (Beclabuvir OR BMS-791325 OR BCV).
  • 22. Try yourself We want to know the effects of eicosapentaenoic acid (EPA) in depression. What's your proposed search strategy?
  • 23. 23 Steps of developing a research proposal Title of the research Background information and statement of the research problem (scientific justification for the study) Research objectives Research hypothesis Methodology Work plan Plan for utilization and dissemination of research results References Budget preparation Annexes