The nurses' role in treating sepsis includes administering IV fluids, pressors, and antibiotics; ensuring labs are ordered and results are available; and meeting treatment goals within specified timeframes while prioritizing patient safety. Antibiotics should be given within 1 hour for non-ED patients and 3 hours for ED patients to reduce mortality risk. Broad-spectrum antibiotics are administered initially before narrowing treatment based on lab results. Sepsis claims over 1,400 lives daily worldwide, demonstrating the importance of prompt antibiotic therapy in improving survival for these critically ill patients.