ºÝºÝߣ

ºÝºÝߣShare a Scribd company logo

Monitoring Pulmonary Arterial Hypertension with Telemetry

•Download as PPTX, PDF•
•
CorDynamics
CorDynamics

CorDynamics adds a powerful capability to its leading suite of pulmonary arterial hypertension models – the ability to record pulmonary artery pressures in the rat.

1 of 3
Downloaded 10 times
CorDynamics adds a powerful capability to its leading suite of pulmonary arterial hypertension models – the ability to record pulmonary artery pressures in the rat Multiple options 1) single pressure OR dual pressure - for differential effects on both arterial beds 2) increased frequency of pulmonary artery pressure readings - characterize development of PAH - critical to test efficacy in prevention AND reversal mode - design studies with more efficiency
Telemetry pressure catheter was placed into pulmonary artery via right ventricle - animals were allowed to recover, administered SU5416, then placed in low oxygen environment - low technical failure rate Clinical observations consistent with development of strong pulmonary hypertension - At Day 42, 438% increase in pulmonary artery pressure vs. baseline - at Day 42, animals euthanized and robust RV hypertrophy confirmed - mean RV/LV+S ratio was .624 ± .079; normal = ~ .300
Telemetered Hemodynamic Evaluation of Vehicle Administration in the Rat Pulmonary Arterial Hypertension Model Induced with Semaxanib (Day 1) and a Low Oxygen Environment - Systolic Pulmonary Artery Pressure 180 160 140 120 (mm Hg) 100 80 60 40 Vehicle 20 0 -5 0 5 10 15 20 25 30 35 40 45 Days of Hypoxia

More Related Content

Monitoring Pulmonary Arterial Hypertension with Telemetry

  • 1. CorDynamics adds a powerful capability to its leading suite of pulmonary arterial hypertension models – the ability to record pulmonary artery pressures in the rat Multiple options 1) single pressure OR dual pressure - for differential effects on both arterial beds 2) increased frequency of pulmonary artery pressure readings - characterize development of PAH - critical to test efficacy in prevention AND reversal mode - design studies with more efficiency
  • 2. Telemetry pressure catheter was placed into pulmonary artery via right ventricle - animals were allowed to recover, administered SU5416, then placed in low oxygen environment - low technical failure rate Clinical observations consistent with development of strong pulmonary hypertension - At Day 42, 438% increase in pulmonary artery pressure vs. baseline - at Day 42, animals euthanized and robust RV hypertrophy confirmed - mean RV/LV+S ratio was .624 ± .079; normal = ~ .300
  • 3. Telemetered Hemodynamic Evaluation of Vehicle Administration in the Rat Pulmonary Arterial Hypertension Model Induced with Semaxanib (Day 1) and a Low Oxygen Environment - Systolic Pulmonary Artery Pressure 180 160 140 120 (mm Hg) 100 80 60 40 Vehicle 20 0 -5 0 5 10 15 20 25 30 35 40 45 Days of Hypoxia