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COVID19
FROM ATO Z
Goran Q. Othman
Cell Biologist
Erbil Polytechnic University
5th April 2020
The Origin of SARS-COV2
The Origin of SARS-COV2
COVID 19 from a to z
COVID 19 from a to z
COVID 19 from a to z
COVID 19 from a to z
The growing curve of death cases since 30 days of 1st recorded
The growing curve of confirmed cases per day
Note the growth rate.. From tens per day in Feb to 100k per day in April
The Math. Of Epidemic: SIR Model
The Math. Of Epidemic: SIR Model
The Math. Of Epidemic: SIR Model
The Math. Of Epidemic: SIR Model
One of the controlling strategies is
Factors to be considered in Modified SIR model for COVID 19 in any region
 S= Number of Susceptible
individuals
 I= Number of Exposed individuals
 R= Number of recovered
individuals
 A= Number of Asymptomatic
infected individuals
 M= Number of Mild infected
individuals
 H= Number of hospitalized infected
individuals
 N= Total number of Kurdistan
people
硫1= Transmission coefficient of the
asymptomatic infected cases to the susceptible
硫2= Transmission coefficient of the mild
infected cases to the susceptible
硫3= Transmission coefficient of the hospitalized
infected cases to the susceptible
-1=Mean incubation period
了-1= Mean time between symptom onset to
hospitalization
1
-1= Mean of infectious period of
asymptomatic infected person for survivors
2
-1= Mean of infectious period of hospitalized
infected person for survivors
隆-1= Mean time for hospitalized to death
粒= Clinical outbreak rate in all the infected
cases
COVID 19 from a to z
COVID 19 from a to z
Role of S glycoprotein and ACE2 in virus entry
COVID 19 from a to z
COVID 19 from a to z
COVID 19 from a to z
Pathological Findings
Problems facing our immune system
COVID 19 from a to z
Problems facing our immune system
COVID 19 from a to z
Best targets for treatment..Blocking infection
Kruse RL. Therapeutic strategies in an outbreak scenario to
treat the novel coronavirus originating in Wuhan,
China [version 2; peer review: 2 approved] F1000Research 2020,
9:72 (https://doi.org/10.12688/f1000research.22211.2)
Current Treatment Options
 Among the potential treatments for COVID-19 that are
undergoing clinical trials to assess their safety and efficacy against
the disease are:
 remdesivir (investigational)
 lopinavir/ritonavir (currently authorised as an anti-HIV medicine)
 chloroquine and hydroxychloroquine (currently authorised at
national level as treatments against malaria and certain
autoimmune diseases such as rheumatoid arthritis)
 systemic interferons and in particular interferon beta (currently
authorised to treat diseases such as multiple sclerosis)
 monoclonal antibodies with activity against components of the
immune system
 Ivermectin which is used as antiparasites especially related to skin

More Related Content

COVID 19 from a to z

  • 1. COVID19 FROM ATO Z Goran Q. Othman Cell Biologist Erbil Polytechnic University 5th April 2020
  • 2. The Origin of SARS-COV2
  • 3. The Origin of SARS-COV2
  • 8. The growing curve of death cases since 30 days of 1st recorded
  • 9. The growing curve of confirmed cases per day Note the growth rate.. From tens per day in Feb to 100k per day in April
  • 10. The Math. Of Epidemic: SIR Model
  • 11. The Math. Of Epidemic: SIR Model
  • 12. The Math. Of Epidemic: SIR Model
  • 13. The Math. Of Epidemic: SIR Model
  • 14. One of the controlling strategies is
  • 15. Factors to be considered in Modified SIR model for COVID 19 in any region S= Number of Susceptible individuals I= Number of Exposed individuals R= Number of recovered individuals A= Number of Asymptomatic infected individuals M= Number of Mild infected individuals H= Number of hospitalized infected individuals N= Total number of Kurdistan people 硫1= Transmission coefficient of the asymptomatic infected cases to the susceptible 硫2= Transmission coefficient of the mild infected cases to the susceptible 硫3= Transmission coefficient of the hospitalized infected cases to the susceptible -1=Mean incubation period 了-1= Mean time between symptom onset to hospitalization 1 -1= Mean of infectious period of asymptomatic infected person for survivors 2 -1= Mean of infectious period of hospitalized infected person for survivors 隆-1= Mean time for hospitalized to death 粒= Clinical outbreak rate in all the infected cases
  • 18. Role of S glycoprotein and ACE2 in virus entry
  • 23. Problems facing our immune system
  • 25. Problems facing our immune system
  • 27. Best targets for treatment..Blocking infection Kruse RL. Therapeutic strategies in an outbreak scenario to treat the novel coronavirus originating in Wuhan, China [version 2; peer review: 2 approved] F1000Research 2020, 9:72 (https://doi.org/10.12688/f1000research.22211.2)
  • 28. Current Treatment Options Among the potential treatments for COVID-19 that are undergoing clinical trials to assess their safety and efficacy against the disease are: remdesivir (investigational) lopinavir/ritonavir (currently authorised as an anti-HIV medicine) chloroquine and hydroxychloroquine (currently authorised at national level as treatments against malaria and certain autoimmune diseases such as rheumatoid arthritis) systemic interferons and in particular interferon beta (currently authorised to treat diseases such as multiple sclerosis) monoclonal antibodies with activity against components of the immune system Ivermectin which is used as antiparasites especially related to skin