�ݺ�ߣ

CPCSEA & OECD GUIDELINES
FOR LABORATORY ANIMAL
BY
Dr. SARITA SHARMA
ASSOCIATE PROFESSOR
DEPARTMENT OF PHARMACOLOGY
MMCP, MMDU

CPCSEA & OECD GUIDELINES FOR LABORATORY ANIMAL B PHARMA.pptx

CPCSEA Renamed as CCSEA
• Committee for the Purpose of Control and
Supervision of Experiments on
Animals (CPCSEA)
• Committee for Control and Supervision of
Experiments on Animals (CCSEA)

WHY ANIMALS ARE USED IN
RESEARCH

Reasons
for human
 The principle of anatomy and physiology are true
and , especially mammals .
Certain strains or breeds of animals get the same disease
or conditions as humans.
With animals we can control their environment
(temperature , humidity, etc) and shield them from
disease or condition not related to the research ( control
their health).
 We can use scientifically – valid no. of animals.

Animal procurement
• All animals must be acquired lawfully as per the CPCSEA
guidelines.
• A health surveillance program for screening incoming animals
should be carried out to assess animal quality.
• Methods of transportation should also be taken into account.
• Each consignment of animals should be inspected for
compliance with procurement specifications, and the animals
should be quarantined and stabilized according to procedures
appropriate for the species and circumstances.

STABILIZATION AND SAPARATION
STABILIZATION-
 Physiologic, psychological and nutritional stabilization should be given
before their use.
 Duration of stabilization will depend on type and duration of
animal transportation, and species of animal.
 SEPARATION-
 Physical separation of animal by species is recommended to prevent
interspecies disease transmission and to eliminate anxiety and
possible physiological and behavioural changes due to
interspecies conflict.
 It shall be acceptable to house different species in the same
room ,e.g. two species have a similar pathogen status and are
behaviourally compatible.

TRANSPORT OF LABORATORY
ANIMALS
• The main considerations for transport of animals
are the mode of transport,
• the containers, the animal density in cages, food
and water during transit,
• protection from transit infection, injuries and
stress.

(eu =good. thanatos =death)
To stop the suffering
• End of experiment , to provide tissue for scientific purpose.
• Diseased animal or animal in bad condition

FOOD
• Should be fed palatable, non-contaminated and
nutritionally adequate food.
• Diet should be free from heavy metals.
BEDDING
 Absorbent, free of toxic chemicals or other substances
that could injure animals or personnel
 Should be removed and replaced with fresh materials as
often as necessary to keep animal clean and dry.

WATER:
• Ordinarily animals should have continuous access to
fresh, potable, uncontaminated
• drinking water, according to their particular
requirements.
SANITATION CLEANLIESS:
• Sanitation is essential in an animal facility. Animal
rooms,
corridors, storage spaces, and
• other areas should be cleaned with appropriate

Waste disposal
• Wastes should be removed regularly and frequently. All waste
should be collected and
• disposed in a -safe and sanitary manner. The most
preferred method of waste disposal is incineration.
EMERGENCY, WEEKEND AND HOLIDAY
CARE
• Animal should be cared for by qualified personnel every day,
including weekends and holidays, to safeguards their well-
being including emergency veterinary care

�ݺ�ߣ

CPCSEA & OECD GUIDELINES FOR LABORATORY ANIMAL B PHARMA.pptx

More Related Content

CPCSEA & OECD GUIDELINES FOR LABORATORY ANIMAL B PHARMA.pptx