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Curriculum Vitae of Peilin Ma 2017
- 1. Curriculum Vitae Peilin Ma, MD, PhD Assistant ResearchProfessor Department of Pathology, Indiana University, School of medicine Room E374, 950 W Walnut Street, Indianapolis, IN, 46202 Tel: 317-274-1667 Cell: 317-469-3146 E-mail: pema@iupui.edu mapeilin3654@gmail.com EDUCATION 2001-2004 PhD, Department of Immunology, Harbin Medical University, Harbin, China 1992-1997 MD, Clinical Medicine, Harbin Medical University, Harbin, China ACADEMICEXPERIENCE Indiana University School of Medicine Indianapolis, IN Assistant Research Professor with Dr. Jay L. Hess 2014-present Characterized the interaction between HoxA9 and FLT3-ITD induced constitutive activation of Stat5 in the development of acute myeloid leukemia (AML) Identified the genomic and epigenetic effect of C/EBP留 mutations in AML Explored the role of HoxA9-regulated transcription of FLT3 in AML University ofMichigan Ann Arbor, MI Research Investigator with Dr. Jay L. Hess 2012-2014 Characterized the interaction between HoxA9 and FLT3-ITD induced constitutive activation of Stat5 in the development of acute myeloid leukemia (AML) Identified the genomic and epigenetic effect of C/EBP留 mutations in AML Explored the role of HoxA9-regulated transcription of FLT3 in AML Indiana University School of Medicine Indianapolis, IN Postdoctoral fellow and Research Associate with Dr. Reuben Kapur 2006-2012 Characterized the role of Rho kinase (ROCK) in KIT,FLT3 and BCR-ABL associated leukemia Identified and characterized multiple cell signaling molecules including Pak,Rac GTPases,SHP2 in oncogenic KITinduced neoplasms Identified the role of class IA phosphatidylinositol-3-kinase and SHIP in the maturation of mast cells Characterized the role of intracellular tyrosines in activating KIT induced myeloproliferative disease Demonstrated the role of SHP2 phosphatase in KIT-induced transformation Indiana University School of Medicine Indianapolis, IN Postdoctoral fellow with Dr. Gotz von Bulow 2005-2006 Cloning of the knock-out mouse of transmembrane activator and calcium-modulator and cytophilin ligand interactor (TACI) Harbin Medical University Harbin, China
- 2. PhD. student with Dr. Fengmin Zhang 1999-2004 Epidemiological study of the infection of Borna disease virus (BDV) in north-east of China and isolation and characterization of BDV HONARSAND AWARDS 1. ASH Abstract Achievement Award (2011), 53rd American Society of Hematology (ASH) AnnualMeeting, San Diego, CA. 2. Second Place of Basic Science Award (2010), Indiana University Simon Cancer Center Cancer Research Day, Indianapolis, IN. 3. Third place ofTranslation/Clinical Research Award (2010),Indiana University Simon Cancer Center Annual Cancer Research Day, Indianapolis, IN. 4. Travel Award (2007),49th American Society of Hematology (ASH) Annual Meeting, Atlanta, GA. PUBLICATIONS 1. Ma P, Song W, Hess JL. A new target for differentiation therapy in AML. Cell Research, 2016, Nov 11. 2. Ghosh J,Kobayashi M, Ramdas B,Chatterjee A, Ma P,Mali RS,Carlesso N,Liu Y, Plas DR3,Chan RJ*, and Kapur R. S6K1 regulates Stem Cell Self-Renewal and Leukemia Maintenance. Journal of Clinical Investigation, 2016, 126(7): 2621-2625. 3. Zhou Bo, Wang JY, Lee SY, Xiong J, Bhanu N, Guo Q, Ma P, Sun YQ, Rao RC, Garcia BA, Hess JL, PRDM16suppressesMLL leukemia via intrinsic histone Methyltransferase Activity. MolecularCell,2016, 62(2): 222-236. 4. Li XJ, Deng L, Brandt S, Goodwin CB, Ma P, Yang ZY, Mali RS, Liu ZY, Kapur R, Serezani CH and Chan RJ. Role of p85留 in Neutrophil Extra- and Intra-Phagosomal ROS Generation. Oncotarget,2016, 7(17): 2309623105. 5. Martin H*, Mali RS*, Ma P*, Chatterjee A, Ramdas B, Sims E, Munugalavadla V, Ghosh J, Mattingly R, Visconte V, Tiu RV, Vlaar CP, Dharmawardhane S, Kapur R. Pak and Rac GTPases promote oncogenic KITinduced neoplasms. Journal of Clinical Investigation. 2013, 123(10):4449-63. * These authors contribute equally to this paper. 6. Ma P, Mali RS, Martin H, Ramdas B, Sims E, and Kapur R. Role of intracellular tyrosines in activating KIT induced myeloproliferative disease. Leukemia. 2012, 26(7):1499-506. 7. Song W, Xiao Y, Chen H, Ashpole NM, Piekarz AD, Ma P, Hudmon A, Cummins TR, Shou W. The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity. The Journal of Physiology. 2012, 590(Pt 20):5123-39. 8. Mali RS*, Ma P*, Zeng LF, Martin H, Ramdas B, He Y, Sims E, Ghosh J, Nabinger S, Li S, Munugalavadla V, Chatterjee A, Sandusky G, Craig AW, Bunting KD, Feng GS, Chan RJ, Zhang ZY, Kapur R. Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood. 2012, 120(13):2669-78. * These authors contribute equally to this paper. 9. Krishnan S, Mali RS, Ramdas B, Sims E, Ma P, Munugalavadla V, Hanneman P, Beane JD, and Kapur R. p85硫 regulatory subunit of class IA PI3 Kinase negatively regulates mast cell growth, maturation and leukemogenesis. Blood. 2012, 119(17):3951-61. 10. Vemula S, Shi JJ, Mali RS, Ma P, Hanneman P, Wei L and Kapur R. ROCK1 functions as a critical regulator of stress erythropoiesis by regulating p53. Blood. 2012, 120(14):2868-78. 11. Krishnan S, Mali RS, Koehler KR, Vemula S, Chatterjee A, Ghosh J, Ramdas B, Ma P, Hashino E, Kapur R. Class IA PI3Kinase regulatory subunit, p85留, mediates mast cell development through regulation of growth and survival related genes. PLoS ONE. 2012; 7(1):e28979. 12. Ma P, Mali RS, Munugalavadla V, Krishnan S, Ramdas B, Sims E, Martin H, Ghosh J, Li S, Chan RJ, Krystal G, Craig AW, Takemoto C, Kapur R. The phosphatidylinositol-3-kinase pathway via microphthalmia transcription factor drives the maturation of mast Cells. Blood. 2011, 118(13):3459-69.
- 3. 13. Ma P, Vemula S, Munugalavadla V, Chen J, Sims E, Borneo J, Kondo T, Ramdas B, Mali RS, Li S, Hashino E, Takemoto C, Kapur R. Balanced interactions between Lyn, p85留 regulatory subunit of class IA phosphatidylinositol-3-kinase and SHIP is essential for mast cell growth and maturation. Molecular and Cellular Biology. 2011; 31(19):4052-62. 14. Mali RS*, Ramdas B*, Ma P, Shi J, Munugalavadla V, Sims E, WeiL, Vemula S, Nabinger SC, Goodwin CB, Chan RJ, Traina F, Visconte V, Tiu RV, Lewis TA, Stern AM, Wen Q, Crispino JD, Boswell HS, Kapur R. Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3 and BCR-ABL. Cancer Cell. 2011; 20 (3):357-69. * These authors contribute equally to this paper. 15. Orschell CM, Borneo J, Munugalavadla V,Ma P, Sims E, Ramdas B,YoderMC and Kapur R. Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cells. Experimental Hematology. 2008; 36 (5): 655-666. ORAL AND POSTER PRESENTATIONS 1. Ma P, Sun YQ, Wang JY,Song WH, Xu T, Kapur R, Hess JL. The role of STAT5 in HOXA9-associated leukemia. 58th American Society of Hematology (ASH) Annual Meeting, San Diego, CA, Dec 2016. 2. Ma P, Sun YQ,Wang JY, Bronstein J, Li BH, Song WH, Hess JL. Interaction between HoxA9 and Stat5 in MLL-associated Leukemia.12th Midwest Blood Club Symposium, French Lick, Indiana, Oct, 2015. 3. Ghosh J, Ramdas B, Chatterjee A, Ma P, Mali R and Kapur R. Role of P70S6 kinase in regulation of normal and stress hematopoiesis. 42nd Annual Scientific Meeting of the International Society for Experimental Hematology (ISEH), Vienna, Austria, Aug 2013. 4. Martin H, Mali R, Ma P, Chatterjee A, Vlaar C, Ramdas B, Dharmawardhane S, Visconte V, Tiu R and Kapur R. P21-activated kinase and guanine exchange factors for Rac GTPases in oncogenic KIT induced systemic mastocytosis and acute myeloid leukemia. 42nd Annual Scientific Meeting of the International Society for Experimental Hematology (ISEH), Vienna, Austria, Aug 2013. 5. Martin H, Ma P, Chatterjee A, Ramdas B, Sims E, Vlaar C, Dharmawardhane S and Kapur R. Role of p21 Activated Kinase and Specific Guanine Exchange Factors of Rac Gtpases in Oncogenic KIT Induced Systemic Mastocytosis and Acute Myeloid Leukemia. 54th American Society of Hematology (ASH) Annual Meeting, Atlanta, GA. December, 2012 6. Ma P, Mali RS, Zeng LF, Martin H, Ramdas B, He Y, Sims E, Ghosh J, Nabinger S, Li S, Munugalavadla V, Chatterjee A, Sandusky G, Craig AW, Bunting KD, Feng GS, Chan RJ, Zhang ZY and Kapur R. KIT Induced Myeloproliferative Disease Is Dependent on PI3Kinase and SHP2 Phosphatase: Identification of SHP2 as a Druggable Target for Treating MPD and AML. 53rd American Society of Hematology (ASH) Annual Meeting, San Diego, CA, Dec 2011. (Oral Presentation). 7. Vemula S, Shi JJ, Mali RS, Ma P, Hanneman P, Wei L and Kapur R. (2011) ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53. 53rd American Society of Hematology (ASH) Annual Meeting, San Diego, CA, Dec 2011. (Oral Presentation). 8. Martin H, Chatterjee A, Ma P , Ramdas B, Sims E, and Kapur R. p21 Activated Kinase (PAK) as a Potential Therapeutic Target for Oncogenic KIT in Acute Myelogenous Leukemia. 40th Annual Scientific Meeting of Society for Hematology and Stem Cells (ISEH), Vancouver, Canada, Aug 2011. 9. Kapur R, Ma P, Zeng LF, Martin H, Ramdas B, He Y, Sims E, Ghosh J, Nabinger S, Li S, Munugalavadla V, Sandusky G, Craig AW, Bunting KD, Feng GS, Chan R, Zhang Z. Singh Mali. KIT induced myeloproliferative disease is dependent on PI3K andSHP2phosphatase: identification of SHP2 as a novel druggable target for treating MPD and AML. 9th Annual Midwest Blood Club Symposium, Cincinnati, OH, Apr 2011. (Oral presentation) 10. Mali RS, Ramdas B, Ma P, Munugalavadla V, Sims E, Shi JJ, Wei L, Lewis TA, Stern AM, Wen Q, Crispino JD, Boswell HS, Kapur R. (2011) Phosphorylation of myosin light chain by Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT. 9th Annual Midwest Blood Club Symposium, Cincinnati, OH, Apr 2011. 11. Martin H, Chatterjee A, Ma P, Ramdas B, and Kapur R. Rac GTPases and Pak as Potential Therapeutic Targets of Oncogenic KIT in Acute Myelogenous Leukemia. 9th Midwest Blood Club Symposium Conference, Cincinnati, OH, Apr 2011. 12. Ma P, Martin H, Sims E, Baskar R, Ghosh J and Kapur R. Role of Intracellular Tyrosine Residues in Oncogenic KIT-Induced Transformation. 8th Annual Midwest Blood Club Symposium, Indianapolis, IN,
- 4. May 2010. (Oral Presentation) 13. Martin H, Ma P, Ramdas B, and Kapur R. Cooperation of AML1-ETO and oncogenic Kit in Acute Myelogenous Leukemia. 8th Annual Midwest Blood Club Symposium, Indianapolis, IN, May 2010. 14. Ma P, Martin H, Sims E, Baskar R, Ghosh J and Kapur R. Role of Intracellular Tyrosine Residues in Oncogenic KIT-Induced Transformation. 51st American Society of Hematology (ASH) Annual Meeting, New Orleans, LA, Dec 2009. 15. Ma P, Kapur R. Repression of ROCKII by GATA-1 Inhibits Cell Proliferation during Erythroid Maturation. 49th American Society of Hematology (ASH) Annual Meeting, Atlanta, GA, Dec 2007.