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CV of Dr.Qinghua Wu
- 1. - 1 - Qing-Hua Wu, Ph.D *1981. 10. 05 College of Life Science, Yangtze University, Jingzhou 434025, Hubei, China Email: wqh212@hotmail.com Tel: +86 130 4090 7294 Scientific Career Since 04/2014 Lecture in College of Life Science, Yangtze University Since 04/2014 Invited professor of Faculty of Informatics and Management of the University Hradec Kralove (Czech Republic). 09/2007-12/2013 Veterinary Pharmacology and Toxicology, Huazhong Agricultural University, Ph.D (Supervisor: Prof. Dr. Zonghui Yuan) 09/2010-09/2011 Visiting Scholar in Muenster University, Institute of Food Chemistry, Germany. Supervisor: Prof. Dr. Humpf, Hans-Ulrich 09/2002-06/2006 Department of Animal Science, Bachelor's Degree, Yangtze University Research Profile The research interests of Dr Qinghua Wu are focusing on metabolism, chemical structure-activity relationships (SAR), toxicity, and signal transduction pathway of mycotoxins. The mycotoxins are concerned on trichothecenes. The functional crosstalk of MAPK-JAK/STAT signaling pathways induced by trichothecenes are investigated. The regulation of cell apoptosis and survival by signal pathways as well as the nuclear translocation of the important proteins to perform the functions are highly concerned. In metabolism study, biotransformation of T-2 toxin in the liver and intestine of food-producing animals such as pig, chicken and carp are investigated. The metabolic differences among these species were compared. In addition, another special interest is the degradation and the formation of degradation products during extrusion cooking. A range of systematic studies of physicochemical parameters such as temperature, moisture, compression, residence time, pH value and protein content on the impact of deoxynivalenol decomposition during extrusion cooking were studied.
- 2. - 2 - Visiting Scholarships Muenster University, Germany, Institute of Food Chemistry in the Working Group of Humpf, Hans-Ulrich, Prof. Dr. rer.nat. (09/2010¡ª9/2011). Professional Specialties Having good knowledge in pharmacokinetics and the related methods. Being good at manipulating HPLC and different mass spectrometries, such as HPLC-MS-IT-TOF, HPLC-Qrbitrap-MS/MS, HPLC-ESI-MS/MS, and Fourier transform mass spectrometry (FTMS), etc. Proficiency in operating food processing extrudor and analysis of the ingredients and drugs in foods. Received systematic training in molecular biology, being good at molecular biology experiments, such as the extraction of the genes and protein, two-dimensional electrophoresis separation and protein bioinformmatic analysis. Familiar with a variety of optical instruments, such as transmission electron microscopy and confocal laser scanning microscopy. Having strong ability to work in a team and guide team members in research. Devote to work with passion, pioneering spirit and innovation. Awards 1) Three-A student in Huazhong Agricultural University, China (2009 and 2010) 2) Huazhong Agricultural University North America Alumnus Alliance Blue Sky Scholarship (2010) 3) Special Reporter Award of the Graduate Academic Conference Huazhong Agricultural University, China (2009 and 2011) 4) Visiting Scholar Award of China Scholarship Council, China (2010) 5) Award of ¡°Shizishan Good Students¡±, Huazhong Agricultural University, China (2011) 6) Award of ¡°Granduate Student Model¡±, Huazhong Agricultural University, China (2011) 7) Award of ¡°Best Academic Reporter¡±, National Veterinary Doctor Forum (2011) 8) China PhD Scholarship award (2012) 9) Award of Outstanding Research Paper in China Hubei Society for Toxicology (2014) 10) Second Award of Outstanding Academic Paper in Hubei China (2014) Membership in Editorial Boards Military Medical Science Letters; International Journal of Veterinary Science and Research; Jacobs Journal of Drug Metabolism and Toxicology; Journal of Food Science and Technology Membership in professional organizations Since 11/2014 member in Chinese Society for Cell Biology
- 3. - 3 - Since 11/2014 member in American Chemical Society (ACS) Since 10/2014 member in China Hubei Society for Toxicology Since 10/2014 member in China Food Science Society Reviewers Military Medical Science Letters; Toxicology and Industrial Health; Environmental Science and Pollution Research; Sky Journal of Agricultural Research; Journal of Toxicology and Environmental Health Sciences; Neural Regeneration Research; Asian Journal of Ecotoxicology; Journal of Veterinary Medicine and Animal Health Publications (*corresponding author) Qinghua Wu, Xu Wang, Wei Yang, Andreas K. Nussler, Ling-Yun Xiong, Kamil Kuca, Vlastimil Dohnal, Xiu-Juan Zhang, Zong-Hui Yuan. Oxidative stress mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update. Archives of Toxicology, 2014, 88: 1309-1326. (Key Scientific Article in 2014 Global Medical Discovery) Qinghua Wu, Xu Wang, Dan Wan, Juan Li. Crosstalk of JNK1-STAT3 is critical for RAW264.7 cell survival. Cellular Signalling. 2014, 26: 2951-2960. Vlastimil Dohnal, Qinghua Wu*, Kamil Kuca. Metabolism of aflatoxins: key enzymes and interindividual as well as interspecies differences. Archives of Toxicology. 2014, 88, 1634-1644. Zhonghong Wang, Qinghua Wu*, Kamil Kuca, Vlastimil Dohnal, Zhihong Tian. Deoxynivalenol: signaling pathways and human exposure risk assessment¡ªan update. Archives of Toxicology. 2014, 88: 1915-1928. Qing-Hua Wu, Guang-Xu Wu, Yun Wang, Dan Wan, Xiu-Juan Zhang, Zong-Hui Yuan. Deoxynivalenol: metabolism and regional differences in human exposure. Military Medical Science Letters. 2014, 83, 114-119. Qinghua Wu, Zonghui Yuan, Xiujuan Zhang. The Cell Survival Function of JNK. Military Medical Science Letters. 2014, 83:28-33. Qinghua Wu, Vlastimil Dohnal, Kamil Kuca, Zonghui Yuan. Trichothecenes: Structure-Toxic Activity relationships. Current Drug Metabolism, 2013, 14(6) 641-660 Qinghua Wu, Anna Engemann, Benedikt Cramer, Tanja Welsch, Zonghui Yuan, Hans-Ulrich Humpf. Intestinal metabolism of T-2 toxin in the pig cecum model. Mycotoxin Research. 2012, 28: 191-198. Qinghua Wu, Lingli Huang, Zhaoying Liu, Min Yao, Yulian Wang, Menghong Dai, Zonghui Yuan. A comparison of hepatic in vitro metabolism of T-2 toxin in rats, pigs, chickens, and carp. Xenobiotica, 2011, 41:863¨C873
- 4. - 4 - Qinghua Wu, Lilia Lohrey, Benedikt Cramer, Zonghui Yuan, Hans-Ulrich Humpf. Impact of physicochemical parameters on decomposition of deoxynivalenol during extrusion cooking of wheat grits. Journal of Agricultural and Food Chemistry. 2011, 59(23): 12480-12485. Qinghua Wu, Vlastimil Dohnal, Lingli Huang, Kamil Kuca, Xu Wang, Guyue Chen, Zonghui Yuan. Metabolic Pathways of Ochratoxin A. Current Drug Metabolism, 2011, 12, 1-10. Qinghua Wu, Vlastimil Dohnal, Lingli Huang, Kamil Ku?a, Zonghui Yuan. Metabolic pathways of trichothecenes. Drug Metabolism Reviews, 2010, 42(2): 250-267. Qinghua Wu, Alena Je?kov¨¢, Zonghui Yuan, Lucie Pavl¨ªkov¨¢, Vlastimil Dohnal. Biological degradation of aflatoxins. Drug Metabolism Reviews, 2009, 41(1): 1-7. Qinghua Wu, Lingli Huan, Zonghui Yuan. Metabolism of fusairal mycotoxins in animals. The 9th National Academic Conference of Drug and Chemical Xenobiotical Metabolism. Wuhan, Hubei, 2009: 59-64. Qinghua Wu, Lilia Lohrey, Benedikt Cramer, Zonghui Yuan, Hans-Ulrich Humpf. Fate of deoxynivalenol in wheat grits during extrusion cooking. 33rd Mycotoxin-Workshop, Freising, Germany 30th May-1st June, 2011, p125. Haihong Hao, Guyue Cheng, Menghong Dai, Qinghua Wu and Zonghui Yuan. Inhibitors targeting on cell wall biosynthesis pathway of MRSA. Mol Biosyst. 2012, 8(11): 2828-2838. Dongmei Chen, Xiaoqin Cao, Yanfei Tao, Qinghua Wu, Yuanhu Pan, Lingli Huang, Xu Wang,Yulian Wang, Dapeng Peng, Zhenli Liu, Zonghui Yuan. Development of a sensitive and robust liquid chromatography coupled with tandem mass spectrometry and a pressurized liquid extraction for the determination of aflatoxins and ochratoxin A in animal derived foods. Journal of Chromatography A, 1253 (2012) 110¨C119. Dongmei Chen, Xiaoqin Cao, Yanfei Tao, Qinghua Wu, Yuanhu Pan, et al. Development of a liquid chromatography-tandemmass spectrometry with ultrasound-assisted extraction and auto solid-phase clean-upmethod for the determination of Fusarium toxins in animal derived foods, Journal of Chromatography A (2013), 1311: 21-29 Dan Wan, Lingli Huang, Yuanhu Pan, Qinghua Wu, Xu Wang, et al. Metabolism, distribution and excretion of deoxynivalenol with combined techniques of radio-tracing, HPLC-IT-TOF/MS and online radiometric detection. Journal of Agriculture and Food Chemistry, 2014, 62: 288-296 Xiujuan Zhang, Kamil Ku?a, Vlastimil Dohnal, Lucie Dohnalov¨¢, Qinghua Wu, Chu Wu. Military potential of biological toxins. Journal of Applied Biomedicine. 2014, 12(2) : 63-77
- 5. - 5 - Wangjun Wu, Ruihua Huang, Qinghua Wu, Pinghua Li, Jie Chen, BoJiang Li, Honglin Liu. The role of Sxi 1 in the genesis of muscle cell and skeletal muscle development. International Journal of Biological Sciences. 2014, 10: 983-989.