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The Power of Vaccines



             Prof. David Salisbury CB
Director of Immunisation, Department of Health.
The power of vaccines
The power of vaccines
The power of vaccines
The power of vaccines
The power of vaccines
The power of vaccines
The invention of polio vaccines
Notifications of poliomyelitis, England & Wales. 1912 - 2006
POLIO CASES BY FOUR-WEEK PERIOD
      BRAZIL, 1975 - 1984
       CASES
 500

 450

 400

 350

 300

 250

 200

 150

 100

 50

  0
1988
     More than 125 polio-endemic countries
World Health Assembly resolution to eradicate polio
Oral polio vaccination mass campaigns  the strategy that
                        worked.
Wild Poliovirus, Previous 6 Months
                                  09 Nov 2011  08 May 2012




Wild virus type 1
Wild virus type 3
Wild virus type 1/3
Endemic country
Country with WPV case in previous 6 months
Haemophilus influenzae type b (Hib) E&W;
                                                      1991 - 2009

                                                Confirmed cases of invasive Hib disease in England and Wales 1990-2009
                                  Hib vaccine introduced
                  1000
                                                                                                                          All ages including under five years
                  900                                                                                                     Under five years


                  800
                                                                                                                               Hib booster at 12 months
                  700                                                                                                          introduced into the routine
Number of cases




                                                                                                                               immunisation programme

                  600

                  500                                                                                  Hib Catch-up 1                               Hib Catch-up 2


                  400

                  300

                  200

                  100

                    0
                         1991   1992   1993   1994     1995   1996   1997   1998   1999   2000 2001   2002   2003       2004     2005     2006     2007      2008    2009
                                                                                          Year



Source HPA
Neisseria meningitidis type C (MenC). E&W;
                                                         1998  2009.

                         Introduction of the Meningococcal C vaccine

                        800                                                                         Under 20 years old
Number of Men C cases




                        700
                                                                                                    Over 20 years old
                        600
                        500
                        400
                        300
                        200
                        100
                          0
                                1998      1999      2000       2001    2002   2003   2004   2005   2006   2007   2008   2009

                                                                                 Year

Source HPA
HPV Vaccine Uptake - Routine Cohort (12-13 Year Olds) 2008/09, 2009/10, 2010/11 &
                                             2011/12 Comparison - Monthly Data
       100


           90


           80


           70


           60
% Uptake




           50


           40


           30


           20


           10


            0
                Sep     Oct         Nov          Dec           Jan    Feb           Mar           Apr   May          Jun           Jul     Aug
                                                                                Month
                              1 Dose (Coh 1, 12-13y 2008/09)         2 Dose (Coh 1, 12-13y 2008/09)       3 Dose (Coh 1, 12-13y 2008/09)
                              1 Dose (Coh 7, 12-13y 2009/10)         2 Dose (Coh 7, 12-13y 2009/10)       3 Dose (Coh 7, 12-13y 2009/10)
                              1 Dose (Coh 8, 12-13y 2010/11)         2 Dose (Coh 8, 12-13y 2010/11)       3 Dose (Coh 8, 12-13y 2010/11)
                              1 Dose (Coh 9, 12-13y 2011/12)         2 Dose (Coh 9, 12-13y 2011/12)       3 Dose (Coh 9, 12-13y 2011/12)
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The power of vaccines

  • 1. The Power of Vaccines Prof. David Salisbury CB Director of Immunisation, Department of Health.
  • 8. The invention of polio vaccines
  • 9. Notifications of poliomyelitis, England & Wales. 1912 - 2006
  • 10. POLIO CASES BY FOUR-WEEK PERIOD BRAZIL, 1975 - 1984 CASES 500 450 400 350 300 250 200 150 100 50 0
  • 11. 1988 More than 125 polio-endemic countries World Health Assembly resolution to eradicate polio
  • 12. Oral polio vaccination mass campaigns the strategy that worked.
  • 13. Wild Poliovirus, Previous 6 Months 09 Nov 2011 08 May 2012 Wild virus type 1 Wild virus type 3 Wild virus type 1/3 Endemic country Country with WPV case in previous 6 months
  • 14. Haemophilus influenzae type b (Hib) E&W; 1991 - 2009 Confirmed cases of invasive Hib disease in England and Wales 1990-2009 Hib vaccine introduced 1000 All ages including under five years 900 Under five years 800 Hib booster at 12 months 700 introduced into the routine Number of cases immunisation programme 600 500 Hib Catch-up 1 Hib Catch-up 2 400 300 200 100 0 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 Year Source HPA
  • 15. Neisseria meningitidis type C (MenC). E&W; 1998 2009. Introduction of the Meningococcal C vaccine 800 Under 20 years old Number of Men C cases 700 Over 20 years old 600 500 400 300 200 100 0 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 Year Source HPA
  • 16. HPV Vaccine Uptake - Routine Cohort (12-13 Year Olds) 2008/09, 2009/10, 2010/11 & 2011/12 Comparison - Monthly Data 100 90 80 70 60 % Uptake 50 40 30 20 10 0 Sep Oct Nov Dec Jan Feb Mar Apr May Jun Jul Aug Month 1 Dose (Coh 1, 12-13y 2008/09) 2 Dose (Coh 1, 12-13y 2008/09) 3 Dose (Coh 1, 12-13y 2008/09) 1 Dose (Coh 7, 12-13y 2009/10) 2 Dose (Coh 7, 12-13y 2009/10) 3 Dose (Coh 7, 12-13y 2009/10) 1 Dose (Coh 8, 12-13y 2010/11) 2 Dose (Coh 8, 12-13y 2010/11) 3 Dose (Coh 8, 12-13y 2010/11) 1 Dose (Coh 9, 12-13y 2011/12) 2 Dose (Coh 9, 12-13y 2011/12) 3 Dose (Coh 9, 12-13y 2011/12)