The document summarizes palmitate synthesis from acetyl-CoA and malonyl-CoA. Specifically, it notes that palmitate synthesis requires 8 acetyl-CoA molecules, 7 ATP molecules, 14 NADPH molecules, and 14 hydrogen ions to produce palmitate, 8 CoA molecules, 7 ADP molecules, 7 phosphate ions, and 6 water molecules. It further explains that in palmitate, only 2 carbon atoms come from acetyl-CoA, while the remaining 14 carbon atoms are from malonyl-CoA, which is produced from acetyl-CoA.
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De novo fatty acid synthesis (Palmitic acid)
1. De novo fatty acid
synthesis
Lecture by
S.Mathivanan.,M.Pharm
Asst Professor
Pharmacy
31. Summary of Palmitate synthesis
8 acetyl CoA + 7ATP + 14NADPH + 14H+
Palmitate + 8CoA + 7ADP + 7Pi + 6H2O
In palmitate, out of 16C only 2C comes from
acetyl CoA and 14 are from malonyl CoA that
in turn, is produced by acetyl CoA.