This document discusses diabetes mellitus type 1 and presents a case study. It begins with an introduction to type 1 diabetes, including its epidemiology, pathophysiology, clinical manifestations, diagnosis, and treatments. It then presents a case study of a 7-year-old female patient who presented with symptoms of weight loss, excessive thirst and urination, nausea, and fatigue. Testing revealed her random blood sugar level was elevated, and she was diagnosed with mild ketosis secondary to newly diagnosed type 1 diabetes. The document outlines her treatment plan, which involved insulin injections and dietary modifications to manage her blood glucose levels.
2.  Introduction of DM type 1
 Epidemiology
 Pathophysiology
 Clinical manifestation
 Diagnosis
 Treatments
 Case study
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3.  The disease is characterized by an absolute
deficiency of insulin caused by an autoimmune
attack on the β cells of the pancreas.
 About 10% of the ten million diabetics in USA has
type 1 diabetes, only (2/3)is diagnosed.
 Complication: stroke, heart attack, kidney
disease, eye disease and nerve damage.
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4.  Progressive destruction of pancreatic cells Auto
antibodies cause a reduction of 80% to 90% of
normal cell function before manifestations occur
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9. Weight loss
Polydipsia (excessive thirst)
Polyuria(frequent urination)
Polyphagia(excessive hunger)
Weakness and fatigue
Ketoacidosis
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10. Random blood sugar test :primary screening test
for type 1 diabetes. A blood sample is taken at a
random time.
random blood sugar level
of 200 milligrams per deciliter (mg/dL), or 11.1
millimoles per liter
(mmol/L), or higher suggests diabetes.
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11. Glycated hemoglobin (A1C) test: This test
indicates your child's average blood sugar level for the
past two to three months. Specifically, the test measures
the percentage of blood sugar. attached to the oxygen-
carrying protein in red blood cells (hemoglobin). An A1C
level of 6.5 percent or higher on two separate tests
indicates diabetes
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12.  Blood tests to check for antibodies that are
common in type 1 diabetes
 Urine tests to check for the presence of
ketones, which also suggests type 1 diabetes
rather than type 2
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13. Exogenous insulin:
– Required for all patient with type 1
DM.
Types of insulin
– Human insulin
• Most widely used type of insulin
• Cost-effective
• Likelihood of allergic reaction
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14. Patients name : DP
Age: 7 year
Sex: Female
Weight: 22kg
Presenting symptoms:
 Cold& fever
 Recument stomach
 Nausea vomiting
 Lost weight
 Drinking large quantity of
water& juices
 Wetting bed
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15. Random blood sugar level :14mMol/L(3.5-
10mMol/L)
 Negative for ketone
 Diagnosis of Mild ketosis was made presenting
secondary to newly diagnosed type 1 diabetes
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16.  Nausea vomiting
 Lost weight
 Drinking large quantity of water& juices
 Wetting bed
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19. Resembles to type 1 DM, negative for ketones (lab
data)
Misdiagnosed because patients have mild ketosis
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20.  To reduce blood glucose to normal level
 To reduce any other risk factors which may
be life threatening
 Provide healthy diet
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21. Can be advised with:
 Eat regularly ,choose high fiber food which have low
glycemic index.
 Use less butter cheese eat fewer fatty meals
 Choose yoghurt skimmed milk , steam or baked meals
To monitor regimen:
 Use alternate site for the injection
 Check blood glucose level every month
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