This document provides the definition and an example of using the quotient rule to differentiate a fraction. The quotient rule is defined as the derivative of the denominator times the numerator minus the numerator times the derivative of the denominator, all over the denominator squared. As an example, the derivative of (3x+4)/(x-4) is calculated using the quotient rule and simplifies to (24x-13)/(x-4)^2.