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Digital Techniques for Myocardial
         Perfusion SPECT
         Dr. Muhammad Ayub
        Diplomate Certification Board of Nuclear Cardiology
        Diplomate Certification Board of Cardiovascular CT

       Punjab Institute of Cardiology, Lahore
SINGLE
PHOTON
EMISSION
COMPUTED
TOMOGRAPHY




             A Modern SPECT Gamma Camera
SPECT Equipment
? Camera
  C Single Detector
  C Multi detector
? Analog to digital converter
? Computer interface
  C Data storage
  C Data processing
  C Display
Gamma Camera
? Gantry                    Display
? Camera Heads                                       PHA
  C Collimator              x     y
  C Scintillation Crystal         Lead Shield
  C Photo multiplier
    tubes                        Pulse Processing Electronics

  C PHA
  C ADC                                  PMTs

                                           Crystal
                                           Collimator
Cardiac SPECT Acquisition

                             ? Gamma camera with 1
                               or 2 heads (90 angle)
                             ? 180 rotation
                             ? 32 steps (16 per head
                               if 2)
                             ? Planar projection
                               acquisition at each
                               step
Step and shoot acquisition
Workstation
? Types
    C Unix Workstations
    C PCs, Macs
?   Storage
?   Memory
?   Graphics
?   Software
PHA
Tomographic Acquisition
?   Matrix
?   Angular Range
?   Angular Steps
?   Time per Step
?   Gated Vs non gated acquisition
?   Continuous Vs Step and Shoot
    acquisition
Tomographic Acquisition
? Matrix
  C 64 x 64     Standard
  C 128 x 128
Digital Techniques For Myocardial Perfusion Spect
Digital Techniques For Myocardial Perfusion Spect
Tomographic Acquisition
? Angular Range   RAO
                  135
  C 180 degrees
  C 360 degrees



                             215
                             LPO
Tomographic Acquisition
Angular Steps
  C 3 degrees    Recommended for Tc Studies
  C 6 degrees    Recommended for Tl Studies
  C 12 degrees   Not Recommended
Image Acquisition
? Orbit
  C Circular       Standard
  C Non-circular   Optional
Tomographic Acquisition
    Gated SPECT
Technical Considerations
? QC
 C   Energy
 C   Uniformity
 C   Linearity
 C   COR
Problems
?   Motion Artifacts
?   COR defects
?   Soft tissue attenuation
?   Foreign Objects
Image Processing
?   Filtered Back projection
?   Filtering
?   Iterative Reconstruction
?   Corrections
    C Attenuation Correction
    C Scatter Correction
Theory of Back Projection 1
          0
               22.5
                                  Imaging a point source
                      45          ? Rotating camera head
Point                             ? Step and shoot at 8
source                     67.5     angles over 180
                            90    ? Only photons ? to
                                    camera face are
                                    detected
                                  ? Planar `projection¨
         180                        acquisition at each
                                    step
Back Projection of 4 Ray Sums
                                             Camera angle
                x
                             0<
                                  22.5<
   Depth in
                                      45<
   transaxial
   slice                             67.5<




                    Transaxial Plane
Filtering
? Pre filtering
? 3D Post Filtering
? Types
  C   Low pass
  C   Metz
  C   Wiener
  C   Band
Types of Filters Used
                                            Magnitude
?Ramp filter
   CAlways applied
   CRemoves star-burst effect (good!)
   CAmplifies high frequency noise (bad!)
                                                        Frequency


?Smoothing filter                           1.0

   CE.g. Hanning or Butterworth
   CSmooths image (removes noise            0.0
   generated by ramp filter)
Pre filtration
3 D Post Filter
Low pass Filter
Metz Filter
Wiener Filter
Band Pass Filter
Filter Example: Butterworth




Butterworth
[Cutoff = 0.3 Order =5]   Filtered Raw
                              image
       Filter                            Reconstructed
                                             slice
                                         Too smooth!
Filter Example: Butterworth




Butterworth
[Cutoff = 0.5 Order =5]


       Filter             Filtered Raw   Reconstructed
                              image          slice
                                         Good quality
Image Reconstruction
?   Short Axis
?   Vertical Long Slices
?   Horizontal Long Slices
?   Slice Thickness
Transverse Reconstruction
The Iterative Loop



              Flow chart of a loop in iterative process

? Initial estimate C e.g. uniform object
? Compare forward projection to real projections
? Perform several iterations:
   C Each time, alter original transverse estimate until pseudo-
     projections converge with real ones.
New Methods
                                                  WIDE BEAM RECONSTUCTION




                                     Sharir, T. et al. J Am Coll Cardiol Img 2008;1:156-163



Copyright ?2008 American College of Cardiology Foundation. Restrictions may apply.
Oblique Reformatting
Image Display
?   Cardiac Stress Rest Display Format
?   Colored and Black & White Display
?   3D display
?   Cine Display
?   Animation
The use of different colors (as opposed to intensities) in a translation
table may produce pseudocontouring: the false perception of an edge
when none, in fact, is present. An image that
shows a linear transition from maximal to minimal counts is shown
using 3 different color tables. The steady transition of the image is
shown most faithfully by the gray scale.
Visual scoring
    2
        1
                  100%   Score

                         4   normal     100 - 70%
        0
4
                  70
    3
        2                3   mild       70 - 50%
                  50
        1
4                        2   moderate   50 - 30%
    4
                  30
            4
                         1   severe     30 - 10%
        2         10
4
                   0     0   absent     10 - 0%
Normal Scan
3D Display
Quantitative Display
? Bulls Eye Reconstruction
  C Cequal
  C PTQ map
? Quantitative Gated SPECT Display
PTQ Map
Digital Techniques For Myocardial Perfusion Spect
Segmental analysis
                short-axis                     V-long axis
                              16   9
        8   1                                        17
    7           2        15             10                18
    6           3        14             11                19
        5   4                 13   12                20


     apical                   basal

A four-point                   0   :   normal uptake
grading system                 1   :   slightly decreased uptake
                               2   :   severely decreased uptake
                               3   :   no uptake ; defect
Quantitative Gated SPECT
QGS
Thank You

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Digital Techniques For Myocardial Perfusion Spect

  • 1. Digital Techniques for Myocardial Perfusion SPECT Dr. Muhammad Ayub Diplomate Certification Board of Nuclear Cardiology Diplomate Certification Board of Cardiovascular CT Punjab Institute of Cardiology, Lahore
  • 2. SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY A Modern SPECT Gamma Camera
  • 3. SPECT Equipment ? Camera C Single Detector C Multi detector ? Analog to digital converter ? Computer interface C Data storage C Data processing C Display
  • 4. Gamma Camera ? Gantry Display ? Camera Heads PHA C Collimator x y C Scintillation Crystal Lead Shield C Photo multiplier tubes Pulse Processing Electronics C PHA C ADC PMTs Crystal Collimator
  • 5. Cardiac SPECT Acquisition ? Gamma camera with 1 or 2 heads (90 angle) ? 180 rotation ? 32 steps (16 per head if 2) ? Planar projection acquisition at each step Step and shoot acquisition
  • 6. Workstation ? Types C Unix Workstations C PCs, Macs ? Storage ? Memory ? Graphics ? Software
  • 7. PHA
  • 8. Tomographic Acquisition ? Matrix ? Angular Range ? Angular Steps ? Time per Step ? Gated Vs non gated acquisition ? Continuous Vs Step and Shoot acquisition
  • 9. Tomographic Acquisition ? Matrix C 64 x 64 Standard C 128 x 128
  • 12. Tomographic Acquisition ? Angular Range RAO 135 C 180 degrees C 360 degrees 215 LPO
  • 13. Tomographic Acquisition Angular Steps C 3 degrees Recommended for Tc Studies C 6 degrees Recommended for Tl Studies C 12 degrees Not Recommended
  • 14. Image Acquisition ? Orbit C Circular Standard C Non-circular Optional
  • 15. Tomographic Acquisition Gated SPECT
  • 16. Technical Considerations ? QC C Energy C Uniformity C Linearity C COR
  • 17. Problems ? Motion Artifacts ? COR defects ? Soft tissue attenuation ? Foreign Objects
  • 18. Image Processing ? Filtered Back projection ? Filtering ? Iterative Reconstruction ? Corrections C Attenuation Correction C Scatter Correction
  • 19. Theory of Back Projection 1 0 22.5 Imaging a point source 45 ? Rotating camera head Point ? Step and shoot at 8 source 67.5 angles over 180 90 ? Only photons ? to camera face are detected ? Planar `projection¨ 180 acquisition at each step
  • 20. Back Projection of 4 Ray Sums Camera angle x 0< 22.5< Depth in 45< transaxial slice 67.5< Transaxial Plane
  • 21. Filtering ? Pre filtering ? 3D Post Filtering ? Types C Low pass C Metz C Wiener C Band
  • 22. Types of Filters Used Magnitude ?Ramp filter CAlways applied CRemoves star-burst effect (good!) CAmplifies high frequency noise (bad!) Frequency ?Smoothing filter 1.0 CE.g. Hanning or Butterworth CSmooths image (removes noise 0.0 generated by ramp filter)
  • 24. 3 D Post Filter Low pass Filter
  • 28. Filter Example: Butterworth Butterworth [Cutoff = 0.3 Order =5] Filtered Raw image Filter Reconstructed slice Too smooth!
  • 29. Filter Example: Butterworth Butterworth [Cutoff = 0.5 Order =5] Filter Filtered Raw Reconstructed image slice Good quality
  • 30. Image Reconstruction ? Short Axis ? Vertical Long Slices ? Horizontal Long Slices ? Slice Thickness
  • 32. The Iterative Loop Flow chart of a loop in iterative process ? Initial estimate C e.g. uniform object ? Compare forward projection to real projections ? Perform several iterations: C Each time, alter original transverse estimate until pseudo- projections converge with real ones.
  • 33. New Methods WIDE BEAM RECONSTUCTION Sharir, T. et al. J Am Coll Cardiol Img 2008;1:156-163 Copyright ?2008 American College of Cardiology Foundation. Restrictions may apply.
  • 35. Image Display ? Cardiac Stress Rest Display Format ? Colored and Black & White Display ? 3D display ? Cine Display ? Animation
  • 36. The use of different colors (as opposed to intensities) in a translation table may produce pseudocontouring: the false perception of an edge when none, in fact, is present. An image that shows a linear transition from maximal to minimal counts is shown using 3 different color tables. The steady transition of the image is shown most faithfully by the gray scale.
  • 37. Visual scoring 2 1 100% Score 4 normal 100 - 70% 0 4 70 3 2 3 mild 70 - 50% 50 1 4 2 moderate 50 - 30% 4 30 4 1 severe 30 - 10% 2 10 4 0 0 absent 10 - 0%
  • 40. Quantitative Display ? Bulls Eye Reconstruction C Cequal C PTQ map ? Quantitative Gated SPECT Display
  • 43. Segmental analysis short-axis V-long axis 16 9 8 1 17 7 2 15 10 18 6 3 14 11 19 5 4 13 12 20 apical basal A four-point 0 : normal uptake grading system 1 : slightly decreased uptake 2 : severely decreased uptake 3 : no uptake ; defect
  • 45. QGS