An insulin regimen outlines the type and timing of insulin injections needed to manage blood sugar levels over 24 hours. A once a day regimen uses a long-acting insulin at bedtime and provides baseline coverage but does not control post-meal blood sugars. A twice a day split mix regimen uses an NPH insulin in the morning and evening for baseline coverage along with a rapid-acting insulin before meals. A three times a day combination uses NPH before breakfast and dinner with a rapid-acting insulin before each meal. A four times a day multiple dose regimen uses rapid-acting insulin before each meal along with an NPH at bedtime for flexibility and post-meal control.
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1. Insulin regimens
Regimen Type of insulin Comments
Once a day single
dose
Intermediate
Or
Long acting
At bed time
One injection
should cover
noon meal
1 injection
will last 24hrs
with no
peaks and
less chance
for
hypoglycemi
a
Does not
cover
postprandial
blood sugars
Twice a day
Split mix dose
NPH regular
Or NPH rapid
Before breakfast,
and at dinner
2 injections provide
coverage for 24hrs
Three times a day
Combination of
mixed and single
dose
NPH regular
Or NPH rapid
Before breakfast
and dinner as well
as at bed time
Three injections
provide coverage or
24hrs
Particularly during
early hours
Four times a day
Multiple dose
Regular or rapid
injection
Before breakfast,
lunch and dinner
AND
NPH at bed time
More flexibility is
allowed at meal
times and for
amount of food
intake
Good postprandial
control
Basal bolus Before breakfast,
lunch and dinner
Long acting once a
Four injection
srequired per day