Doctor on Demand - An app business that heals
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An app that will mainly provide doctor's serial number, virtual consultation, emergency home delivery of medicine and emergency blood bank contact numbers.
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Subphylum : Apicomplexa (Sporozoa)
Class : Telosporea
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Species : vivax
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ii) Plasmodium falciparum malignant tertian malaria
iii) Plasmodium ovale mild tertian malaria
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OBJECTIVES AND USE OF ANTIMALARIAL DRUGS
The aims of using drugs in relation to malarial infection are:
(i) To prevent clinical attack of malaria (prophylactic).
(ii) To treat clinical attack of malaria (clinical curative).
(iii) To completely eradicate the parasite from the patients body (radical curative).
(iv) To cutdown human-to-mosquito transmission (gametocidal).
These are achieved by attacking the parasite at its various stages of life cycle in the human host .
Antimalarials that act on erythrocytic schizogony are called erythrocytic schizontocides
Antimalarials that act on pre erythrocytic as well as exoerythrocytic (P. vivax) stages in liver are called tissue schizontocides,
Antimalarials which kill gametocytes in blood are called gametocides.
Severe and complicated falciparum malaria
This includes P. falciparum infection attended by any one or more of
Hyperparasitaemia,
Hyperpyrexia,
Fluid and electrolyte imbalance,
Acidosis,
Hypoglycaemia,
Prostration,
Cardiovascular collapse,
Jaundice,
Severe anaemia,
Spontaneous bleeding,
Pulmonary edema,
Haemoglobinuria,
Black water fever,
Renal failure
Cerebral malaria.
Artesunate: 2.4 mg/kg i.v. or i.m., followed by 2.4 mg/kg after 12 and 24 hours, and then once daily for 7 days. Switchover to 3 day oral ACT in between whenever the patient can take and tolerate oral medication.
or
Artemether: 3.2 mg/kg i.m. on the 1st day, followed by 1.6 mg/kg daily for 7 days. Switchover to 3 day oral ACT in between whenever the patient is able to take oral medication.
or
Arteether: 3.2 mg/kg i.m. on the 1st day, followed by 1.6 mg/kg daily for the next 4 days. Switchover to 3 day oral ACT inbetween whenever the patient is able to take oral medication.
or
Quinine diHCI: 20 mg/kg (loading dose) diluted in 10 ml/kg 5% dextrose/dextrose-saline and infused i.v. over 4 hours, followed by 10 mg/kg.PGDEI Neurobiology - paper 1 NEUROBIOLOGY
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HYPERTENSION
1. Hypertension is defined as persistently elevated arterial blood pressure (BP).
2. Hypertension, also known as high blood pressure, is a chronic medical condition in which the force of blood against the artery walls is consistently too high, increasing the risk of heart disease, stroke, and other health complications.
3. WHO Definition of Hypertension
a. According to the World Health Organization (WHO), hypertension is defined as:
Systolic Blood Pressure (SBP) 140 mmHg
Diastolic Blood Pressure (DBP) 90 mmHg
b. Based on repeated measurements under standardized conditions.
Risk factors
Obesity A sedentary lifestyle
Diabetes mellitus High intakes of salt or alcohol
Family history Stress
Cigarette smoking Low birth weight
Hypertension is described as essential (primary, idiopathic) or secondary to other diseases.
Irrespective of the cause, hypertension commonly affects the kidneys.
Essential hypertension
1. A condition of persistently elevated blood pressure without a known secondary cause, often associated with genetic predisposition and lifestyle factors.
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Secondary hypertension
Hypertension resulting from other diseases accounts for 5% of all cases.
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Raised blood pressure is a complication of many kidney diseases. In kidney disease, there is salt and water retention, sometimes with excessive renin activity.
II. Endocrine disorders
a) Adrenal cortex
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b) Adrenal medulla
Secretion of excess adrenaline (epinephrine) and noradrenaline (norepinephrine) raises blood pressure, e.g. phaeochromocytoma .
III. Stricture of the aorta
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coarctation.
IV. Drug treatment
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Hypertension predisposes to atherosclerosis and has specific effects on particular organs.
Heart
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Subphylum : Apicomplexa (Sporozoa)
Class : Telosporea
Genus : Plasmodium
Species : vivax
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i) Plasmodium vivax benign tertian malaria
ii) Plasmodium falciparum malignant tertian malaria
iii) Plasmodium ovale mild tertian malaria
iv) Plasmodium malariae quartan malaria
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(i) To prevent clinical attack of malaria (prophylactic).
(ii) To treat clinical attack of malaria (clinical curative).
(iii) To completely eradicate the parasite from the patients body (radical curative).
(iv) To cutdown human-to-mosquito transmission (gametocidal).
These are achieved by attacking the parasite at its various stages of life cycle in the human host .
Antimalarials that act on erythrocytic schizogony are called erythrocytic schizontocides
Antimalarials that act on pre erythrocytic as well as exoerythrocytic (P. vivax) stages in liver are called tissue schizontocides,
Antimalarials which kill gametocytes in blood are called gametocides.
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Hypoglycaemia,
Prostration,
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Jaundice,
Severe anaemia,
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Pulmonary edema,
Haemoglobinuria,
Black water fever,
Renal failure
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or
Artemether: 3.2 mg/kg i.m. on the 1st day, followed by 1.6 mg/kg daily for 7 days. Switchover to 3 day oral ACT in between whenever the patient is able to take oral medication.
or
Arteether: 3.2 mg/kg i.m. on the 1st day, followed by 1.6 mg/kg daily for the next 4 days. Switchover to 3 day oral ACT inbetween whenever the patient is able to take oral medication.
or
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2. Hypertension, also known as high blood pressure, is a chronic medical condition in which the force of blood against the artery walls is consistently too high, increasing the risk of heart disease, stroke, and other health complications.
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Systolic Blood Pressure (SBP) 140 mmHg
Diastolic Blood Pressure (DBP) 90 mmHg
b. Based on repeated measurements under standardized conditions.
Risk factors
Obesity A sedentary lifestyle
Diabetes mellitus High intakes of salt or alcohol
Family history Stress
Cigarette smoking Low birth weight
Hypertension is described as essential (primary, idiopathic) or secondary to other diseases.
Irrespective of the cause, hypertension commonly affects the kidneys.
Essential hypertension
1. A condition of persistently elevated blood pressure without a known secondary cause, often associated with genetic predisposition and lifestyle factors.
Benign (chronic) hypertension
1. The rise in blood pressure is usually slight to moderate and continues to rise slowly over many years.
2. Sometimes complications, such as heart failure, cerebrovascular accident or myocardial infarction are the first indication of hypertension, but often the condition is symptomless and is only discovered during a routine examination.
Malignant (accelerated) hypertension
1. This is a rapid and aggressive acceleration of hypertensive disease.
2. Diastolic pressure in excess of 120 mmHg is common.
3. The effects are serious and quickly become apparent, e.g. haemorrhages into the retina, papilloedema (oedema around the optic disc), encephalopathy (cerebral oedema) and progressive renal disease, leading to cardiac failure.
Secondary hypertension
Hypertension resulting from other diseases accounts for 5% of all cases.
I. Kidney disease
Raised blood pressure is a complication of many kidney diseases. In kidney disease, there is salt and water retention, sometimes with excessive renin activity.
II. Endocrine disorders
a) Adrenal cortex
Secretion of excess aldosterone and cortisol stimulates the retention of excess sodium and water by the kidneys, raising the blood volume and pressure.
b) Adrenal medulla
Secretion of excess adrenaline (epinephrine) and noradrenaline (norepinephrine) raises blood pressure, e.g. phaeochromocytoma .
III. Stricture of the aorta
Hypertension develops in branching arteries proximal to the site of a stricture, e.g congenital
coarctation.
IV. Drug treatment
Hypertension may be a side-effect of some drugs, e.g. corticosteroids and oral contraceptives.
Effects and complications of hypertension
The effects of long-standing and progressively rising blood pressure are serious.
Hypertension predisposes to atherosclerosis and has specific effects on particular organs.
Heart
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