This study assessed the availability of essential drugs at 22 Basic Health Units (BHUs) in Larkana district. A questionnaire was used to determine if drugs like Vitamin A, iron/folic acid, ORS packets, antimalarials, antipryretics, and others were physically available. The results found that 59% of antimalarial drugs, 51% of antipryretic drugs, and 16% of ORS packets were not available. Vitamin A supplementation and eye drops in particular were not available at most BHUs. The conclusion is that not all essential drugs are universally available at BHUs in Larkana district after transitioning to PPHI management, and the recommendation is that drugs like Vit