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Drug protein binding

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asraf sohel

This presentation discusses drug protein binding. It covers the impact of altered protein binding on drug metabolism and distribution. Only unbound drug undergoes metabolism; changes in free drug levels alter volume of distribution. Distribution is measured as volume of distribution, which is influenced by typical fluid volumes in the body like plasma and intracellular volume. Equilibrium dialysis is commonly used to measure plasma protein binding but it is a slow process. In conclusion, drug protein binding significantly impacts drug distribution throughout the body.

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Presentation on: Drug protein binding. Presentation by: ALI ASRAF SOHEL ID:2015000300008 Southeast university
Overview Impact of the altered protein binding Distribution and Plasma Protein Binding Measuring Plasma Protein Binding Conclusion
Impact of the altered protein binding Only the unbound fraction of the drug undergoes metabolism in the liver and other tissues As the drug dissociates from the protein more and more drug undergoes metabolism Changes in the levels of free drug change the volume of distribution
Rapidly undergo metabolism, clearance is dependent on the hepatic blood flow. Slowly undergo drug directly change the clearance of the drug. If the amount of plasma protein is decreased (such as liver disease, renal disease), there would also be a higher fraction unbound.
Distribution and Plasma Protein Binding The distribution of a drug is often measured as a volume of distribution. It is also a measure of the fluid volume. It is important to note that the measured volumes are not actual physical volumes.
Typical Liquid Volumes For A 70kg Man Are (% And L) Total Water: 60%, 42 L Intracellular Volume: 40%, 28L Extracellular Volume: 20%, 14L Plasma Volume: 4%, 3L Blood Volume: 8%, 5.5L
Measuring Plasma Protein Binding Equilibrium dialysis is the most widely accepted method for assessing plasma protein binding. But is a relatively slow process, from 4-24 hours at 37 C. For very highly bound compounds it can be difficult to measure the concentration of unbound drug.
Conclusion Overall we can say it drug protein binding is very important for drug distribution. In every step of drug distribution it plays an important role.

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Drug protein binding

  • 1. Presentation on: Drug protein binding. Presentation by: ALI ASRAF SOHEL ID:2015000300008 Southeast university
  • 2. Overview Impact of the altered protein binding Distribution and Plasma Protein Binding Measuring Plasma Protein Binding Conclusion
  • 3. Impact of the altered protein binding Only the unbound fraction of the drug undergoes metabolism in the liver and other tissues As the drug dissociates from the protein more and more drug undergoes metabolism Changes in the levels of free drug change the volume of distribution
  • 4. Rapidly undergo metabolism, clearance is dependent on the hepatic blood flow. Slowly undergo drug directly change the clearance of the drug. If the amount of plasma protein is decreased (such as liver disease, renal disease), there would also be a higher fraction unbound.
  • 5. Distribution and Plasma Protein Binding The distribution of a drug is often measured as a volume of distribution. It is also a measure of the fluid volume. It is important to note that the measured volumes are not actual physical volumes.
  • 6. Typical Liquid Volumes For A 70kg Man Are (% And L) Total Water: 60%, 42 L Intracellular Volume: 40%, 28L Extracellular Volume: 20%, 14L Plasma Volume: 4%, 3L Blood Volume: 8%, 5.5L
  • 7. Measuring Plasma Protein Binding Equilibrium dialysis is the most widely accepted method for assessing plasma protein binding. But is a relatively slow process, from 4-24 hours at 37 C. For very highly bound compounds it can be difficult to measure the concentration of unbound drug.
  • 8. Conclusion Overall we can say it drug protein binding is very important for drug distribution. In every step of drug distribution it plays an important role.