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Ds attri

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Aman Sharma

The document discusses the layout and environmental requirements for a plant manufacturing uncoated and coated tablets. It recommends a layout with three areas - an area for uncoated tablets production of 60 square meters, an area for coating of 30 square meters, and an ancillary area of 20 square meters. Environmental conditions of temperature 25賊5属C and humidity 55賊10%RH are suggested. Different pressure requirements are outlined for different areas like the warehouse, weighing area, and tableting area to prevent cross contamination. Proper air handling systems and controls are necessary to maintain suitable environmental conditions for manufacturing and ensure employee comfort.

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By :- Mr. Dinesh Sharma M Pharma(2nd sem) dsattri592@gmail.com GUIDE LECTURER :- Miss. Japinder kaur M Pharmacist Global College of Pharmacy
Introduction Plant layout Aspects
Designed according to GMP practices which ensures . Prevention of cross contamination Proper air handling systems. Proper cleaning & sanitary facilities. Proper Lighting Proper Plumbing Proper washing etc.
Layout: It is the organized properly planned INTERDEPARTMENT and INTRADEPARTMENT arrangements. PROPER LAYOUT: Increases productivity Helps in proper utilization of - MAN - MATERIAL - MONEY - MACHINES
layout With 1) crossover traffic 2) circular flow 3) Parallel flow
Area : 60+20 sq.meter Deduster 30+10 sq.meter 30 Pascal 10 Pascal 20 Pascal 15 Pascal 15 Pascal Temp. 25+/-5 Humidity : 55+/- 10%RH CROSS OVER TRAFFIC
Area:60+20sq.meter Temp. 25+/-5 Humidity : 55+/- 10%RH 30+10 sq.meter Circular flow
Parallel flow
For Uncoated Tablet For Coating Section For Basic Installation Sq.mtrs. For Ancillary Area Sq.mtrs. 60 30 20 10 AREAAREA REQUIREMENTREQUIREMENT ENVIRONMENTENVIRONMENT REQUIREMENTREQUIREMENT Temperature : 25 賊 5 C Humidity : 55 賊 10 %RH Pressure in Ware House Area: 10 Pascal Pressure in Weighing Area : 20 Pascal Pressure in Tableting Area : 15 Pascal Pressure in Central Corridor : 30 Pascal
Proper maintenance is required for :- o Product Protection o Employee Comfort o Controlled Process Parameters
Name of Area Pressure maintained in pascals Warehouse 10 Weighing area 20 Tableting area 15 Central corridor 30
Low humidity for Effervescent tablets & moisture sensitive drugs. Presure with areas like mixing & tableting area should remain on negative side than central corridor. All area should be free from dust & floating particles , if possible air conditioned . In coating section suitable exhaust systems. There should be properly organized & working air handling system to supply purified air.
Temp control & Air control should be such be that there should be comfortable working environment. And no impact on characteristics of in-process materials such as granulation, raw materials. All areas should be properly ventilated.
Ds attri

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Ds attri

  • 1. By :- Mr. Dinesh Sharma M Pharma(2nd sem) dsattri592@gmail.com GUIDE LECTURER :- Miss. Japinder kaur M Pharmacist Global College of Pharmacy
  • 2. Introduction Plant layout Aspects
  • 3. Designed according to GMP practices which ensures . Prevention of cross contamination Proper air handling systems. Proper cleaning & sanitary facilities. Proper Lighting Proper Plumbing Proper washing etc.
  • 4. Layout: It is the organized properly planned INTERDEPARTMENT and INTRADEPARTMENT arrangements. PROPER LAYOUT: Increases productivity Helps in proper utilization of - MAN - MATERIAL - MONEY - MACHINES
  • 5. layout With 1) crossover traffic 2) circular flow 3) Parallel flow
  • 6. Area : 60+20 sq.meter Deduster 30+10 sq.meter 30 Pascal 10 Pascal 20 Pascal 15 Pascal 15 Pascal Temp. 25+/-5 Humidity : 55+/- 10%RH CROSS OVER TRAFFIC
  • 9. For Uncoated Tablet For Coating Section For Basic Installation Sq.mtrs. For Ancillary Area Sq.mtrs. 60 30 20 10 AREAAREA REQUIREMENTREQUIREMENT ENVIRONMENTENVIRONMENT REQUIREMENTREQUIREMENT Temperature : 25 賊 5 C Humidity : 55 賊 10 %RH Pressure in Ware House Area: 10 Pascal Pressure in Weighing Area : 20 Pascal Pressure in Tableting Area : 15 Pascal Pressure in Central Corridor : 30 Pascal
  • 10. Proper maintenance is required for :- o Product Protection o Employee Comfort o Controlled Process Parameters
  • 11. Name of Area Pressure maintained in pascals Warehouse 10 Weighing area 20 Tableting area 15 Central corridor 30
  • 12. Low humidity for Effervescent tablets & moisture sensitive drugs. Presure with areas like mixing & tableting area should remain on negative side than central corridor. All area should be free from dust & floating particles , if possible air conditioned . In coating section suitable exhaust systems. There should be properly organized & working air handling system to supply purified air.
  • 13. Temp control & Air control should be such be that there should be comfortable working environment. And no impact on characteristics of in-process materials such as granulation, raw materials. All areas should be properly ventilated.