Dupuytrens background info
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What is Dupuytrens Disease? Benign thickening and shortening of the palmar fascia leading to digital contractures Early phase with nodule and cord development, skin retraction Late phase with formation of contracture Who gets Dupuytrens disease? Genetic predisposition Especially in those of Northern European origin Males > Females Age Wide range Increases with age Average age of onset 50 70 years Occurrence Common
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Creatine burst into the public consciousness in 1992 when an investigative reporter inside the Olympic Village in Barcelona caught wind of British athletes using a product called Ergomax C150. This led to an explosion of interest in and questions about the ingredient after high-profile British athletes won multiple gold medals.
I developed Ergomax C150, working closely with the late and great Dr. Roger Harris (1944 2024), and Prof. Erik Hultman (1925 2011), the pioneering scientists behind the landmark studies of creatine and athletic performance in the early 1990s.
Thirty years on, these are the slides I used at the Sports & Active Nutrition Summit 2025 to share the story, the lessons from that time, and how and why creatine will play a pivotal role in tomorrows high-growth active nutrition and healthspan categories.MLS 208 - UNIT 1- Lecture Notes - ETANDO AYUK - SANU - Secured.pdf
MLS 208 - UNIT 1- Lecture Notes - ETANDO AYUK - SANU - Secured.pdfEswatini Medical Christian University - EMCU / Southern Nazarene University - SANU
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Dupuytrens background info
- 1. www.thedupuytrenspractice.comwww.thedupuytrenspractice.com Introduction to Dupuytrens Disease Richard Shaffer Clinical Oncologist
- 2. www.thedupuytrenspractice.com What is Dupuytrens Disease? Benign thickening and shortening of the palmar fascia leading to digital contractures Early phase with nodule and cord development, skin retraction Late phase with formation of contracture
- 3. www.thedupuytrenspractice.com Proximal cord Nodules Normal (tented) skin Distal cord Early disease
- 4. www.thedupuytrenspractice.com Garrods pads More extensive disease with skin retraction
- 5. www.thedupuytrenspractice.com Loss of Hyperextension = inability to bend finger backwards past neutral position 1. Hyperextension 2. Loss of hyperextension 3. Complete loss of hyperextension
- 6. www.thedupuytrenspractice.com Contracture = fixed bending of fingers
- 7. www.thedupuytrenspractice.com Who gets Dupuytrens disease? Genetic predisposition Especially in those of Northern European origin Males > Females Age Wide range Increases with age Average age of onset 50 70 years Occurrence Common
- 8. www.thedupuytrenspractice.com Other contributory factors Smoking Alcohol (excess) Diabetes Manual labour (vibration) Hand trauma
- 9. www.thedupuytrenspractice.com Linked conditions Ledderhose (which is Dupuytrens disease on the foot) Peyronies disease (pain and bending of the penis) Frozen shoulder Garrods pads (painful nodules on the knuckles)
- 10. www.thedupuytrenspractice.com The course of Dupuytrens is unpredictable Some people have no symptoms, and others have pain Some people never get progression past having nodules and/or cords Some people get contracture and need surgical (or other) release, and some may even recur after surgery
- 11. www.thedupuytrenspractice.com The disease is more likely to progress if You are male Young age of onset (less than 50 years old) You have Dupuytrens on your other hand Or other sites e.g. Ledderhose (foot), Peyronies (penis) Your immediate family suffer from Dupuytrens disease; brother, sister, Mother or Father