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Ebolapresentation 120905234621-phpapp01

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N V Amruth Varma

Ebola virus causes a severe hemorrhagic fever in humans and nonhuman primates. It was first discovered in 1976 near the Ebola River in the Democratic Republic of Congo. There are 5 distinct subspecies of Ebola virus. The natural reservoir of the virus is unknown, but it is believed to be animal-borne, primarily occurring in Africa. Symptoms begin with fever, headache, and weakness and progress to vomiting, diarrhea, and hemorrhaging. The mortality rate can be as high as 90% and patients usually die from shock. There is no vaccine for Ebola virus.

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EBOLA VIRUS
WHAT ISA EBOLA - Ebola hemorrhagic fever: Named after a river in the Congo where it was first found - Often-fatal disease in humans and nonhuman primates (monkeys, gorillas, and chimpanzees) - Has appeared sporadically since its initial recognition in 1976 - Mortality rate can reach 90%
-Family: Filoviridae -Order: Mononegavirales -5 distinct sub-species -Cote d¡¯Ivorie(Ivory Coast) ebolavirus -Reston ebolavirus -Sudan ebolavirus -Zaire ebloavirus -Bundibugyo ebolavirus - Characteristics of Filoviruses: - Filamentous form with a uniform diameter of approximately 80 nm but display great variation in length. - Nonsegmented negative-stranded RNA genome containing 7 structural and regulatory genes. Family and Order
Where is the Ebola virus found in nature ? Natural reservoir of the Ebola virus remains unknown. ? Zoonotic (animal-borne) ? Four of the 5 subtypes occur in an animal host native to Africa 1 occurs in Philippine monkeys . ? Origination: Africa...The virus is not known to be native to other continents, such as North America.
Ebolapresentation 120905234621-phpapp01
Modes of Infection
Incubation period is 2-21 days . Symptoms are :- Arthritic pain Backache (low-back pain) Chills Diarrhea Fatigue Fever Headache Malaise (general feeling of being unwell) Nausea Sore throat Vomiting Early Symptoms
Late Symptoms Late symptoms include: ? Bleeding from eyes, ears, and nose ? Bleeding from the mouth and rectum (gastrointestinal bleeding) ? Depression ? Eye inflammation (conjunctivitis) ? Genital swelling (labia and scrotum) ? Increased feeling of pain in skin ? Rash over the entire body that often contains blood (hemorrhagic) ? Roof of mouth looks red ? Seizures, coma, delirium As many as 90% of patients die from the disease. Patients usually die from shock rather than from blood loss.
How it works Threadlike Ebola virions bud from a cell. The Ebola virus disables a cell's tetherin protein. Tetherin: A human cellular protein which inhibits retrovirus infection by preventing the diffusion of virus particles after budding from infected cells

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Ebolapresentation 120905234621-phpapp01

  • 2. WHAT ISA EBOLA - Ebola hemorrhagic fever: Named after a river in the Congo where it was first found - Often-fatal disease in humans and nonhuman primates (monkeys, gorillas, and chimpanzees) - Has appeared sporadically since its initial recognition in 1976 - Mortality rate can reach 90%
  • 3. -Family: Filoviridae -Order: Mononegavirales -5 distinct sub-species -Cote d¡¯Ivorie(Ivory Coast) ebolavirus -Reston ebolavirus -Sudan ebolavirus -Zaire ebloavirus -Bundibugyo ebolavirus - Characteristics of Filoviruses: - Filamentous form with a uniform diameter of approximately 80 nm but display great variation in length. - Nonsegmented negative-stranded RNA genome containing 7 structural and regulatory genes. Family and Order
  • 4. Where is the Ebola virus found in nature ? Natural reservoir of the Ebola virus remains unknown. ? Zoonotic (animal-borne) ? Four of the 5 subtypes occur in an animal host native to Africa 1 occurs in Philippine monkeys . ? Origination: Africa...The virus is not known to be native to other continents, such as North America.
  • 7. Incubation period is 2-21 days . Symptoms are :- Arthritic pain Backache (low-back pain) Chills Diarrhea Fatigue Fever Headache Malaise (general feeling of being unwell) Nausea Sore throat Vomiting Early Symptoms
  • 8. Late Symptoms Late symptoms include: ? Bleeding from eyes, ears, and nose ? Bleeding from the mouth and rectum (gastrointestinal bleeding) ? Depression ? Eye inflammation (conjunctivitis) ? Genital swelling (labia and scrotum) ? Increased feeling of pain in skin ? Rash over the entire body that often contains blood (hemorrhagic) ? Roof of mouth looks red ? Seizures, coma, delirium As many as 90% of patients die from the disease. Patients usually die from shock rather than from blood loss.
  • 9. How it works Threadlike Ebola virions bud from a cell. The Ebola virus disables a cell's tetherin protein. Tetherin: A human cellular protein which inhibits retrovirus infection by preventing the diffusion of virus particles after budding from infected cells

Editor's Notes

  1. What is Ebola?: According CDC, Ebola hemorrhagic fever is a deadly disease in both humans and nonhuman primates (monkeys and chimpanzees) caused by the Ebola virus; characterized by high fever and severe internal bleeding; can be spread from person to person; is largely limited to Africa. First found in the area of the Democratic Republic of the Congo, near the River Congo in 1976 mortality rate: 90%, that¡¯s why is called deadly disease.
  2. Highest fatality Rate is found in the Zaire sub-species. The only reported cases in the U.S., Italy and England were all part of the Reston sub-species.
  3. Natural reservoir of Ebola Virus still unknown until now. Its Zoonotic all 4 of 5 subtypes an animal Host in Africa
  4. The virus itself stores its nucleic acid in the form of a +mRNA genome and serves as a means of delivery of that genome into cells it targets as an obligate parasite (Cannot live independently of the Host cell), and constitutes the infection. Once in the host's cell, the RNA strands undergo reverse transcription in the cytoplasm and are integrated into the host's genome, at which point the retroviral DNA is referred to as a provirus (A provirus is a virus genome that is integrated into the DNA of a host cell). It is difficult to detect the virus until it has infected the host.