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Effect of Hibiscus sabdariffa tea on the hypercholesterolemic Sprague-dawley rats

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Amallia Setyawati
Amallia Setyawati

Hibiscus sabdariffa tea was found to have hypolipidemic effects on hypercholesterolemic rats. The study divided rats into groups that received different doses of Hibiscus sabdariffa tea - 125 mg/kg, 250 mg/kg, and 500 mg/kg - in addition to their normal feeding. Analysis found the tea significantly reduced total cholesterol, LDL, and triglyceride levels in the rats. It also significantly increased HDL cholesterol levels. The hypolipidemic effects are believed to be due to active compounds in Hibiscus sabdariffa such as pectin, niacin, and anthocyanin that increase lipoprotein lipase activity and

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Effect of Hibiscus sabdariffa tea on the hypercholesterolemic Sprague-dawley rats. Tjahjono K*, Setyawati AN*, Novyanto R**, Angelo M**, Pratama MFR**, Dinayanti T** *Department of Biochemistry, Faculty of Medicine Diponegoro University, Semarang, Indonesia **Faculty of Medicine Diponegoro University, Semarang, Indonesia Background: WHO has estimated CVD Method: This was an experiment with pre and - (Cerebrovascular disease) by 2010 to be the most post randomized controlled group design, using leading death factor worldwide. This reflects a hypercholesterolemic male Sprague-dawley rats, significant change in diet habits, physical activity which were divided into 4 groups, the first group levels, and tobacco consumption worldwide. High was placebo (P) with normal feeding, the others blood pressure, high blood cholesterol, overweight were with levelled-up additional feeding of 125 and obesity - and the chronic disease of type 2 mg/Kg weight/day (T1), 250 mg/Kg weight/day diabetes are among the major biological risk (T2), and 500 mg/Kg weight/day (T3). Total factors for CVD. Hibiscus sabdariffa is traditionally cholesterol and HDL were analyzed with GPO-PAP believed to improve hyperlipidemic condition. This method and triglyceride was with Friedewald study was conducted to look for the hypolipidemic method effect of Hibiscus sabdariffa and the dose given difference outcome. Table. Mean pre-and post-treatment values of lipid profile. Result: Post hoc LSD analysis showed that the total cholesterol, LDL and triglyceride were with significant difference between pre and post- experimental paired groups [total cholesterol; LDL; triglyceride, subsequently with p: 0.000; p: 0,000; p:0,000]. There was also a significant increment on HDL cholesterol (p: 0.000). Discussion: The hypolipidemic of Hibiscus sabdariffa between pre and post- experimental is assumed due to pectin, niacin, anthosianin, dan β-sitosterol containment. These active H. sabdariffa flower compounds have been studied and concluded to increase lipoprotein lipase activity, bile-acid bound, and catalytic activity rate of cholesterol which may explain the hypolipidemic effect of Hibiscus sabdariffa. Keyword: Hibiscus sabdariffa, hypercholesterolemia, lipid profile Reference: 1. C.M. Gurrola-Dı´az, et. al. Effect of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid Conclusion: The hypolipidemic of Hibiscus profiles of patients with Metabolic Syndrome (MeSy). Phytomedicine.17, 500–5. sabdariffa between pre and post- experimental is 2. Chen CC, et.al. Hibiscus sabdariffa extract inhibits the assumed due to pectin, niacin, anthosianin, dan β- development of atherosclerosis in sitosterol containment. These active compounds cholesterol-fedrabbits.J.Agric.FoodChem.51,5472–5477 have been studied and concluded to increase lipoprotein lipase activity, bile-acid bound, and Presented in the Indonesian Medical Doctor catalytic activity rate of cholesterol which may Nutrition Society) National Congress, explain the hypolipidemic effect of Hibiscus Semarang, October 15-17th, 2010 sabdariffa.

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Effect of Hibiscus sabdariffa tea on the hypercholesterolemic Sprague-dawley rats

  • 1. Effect of Hibiscus sabdariffa tea on the hypercholesterolemic Sprague-dawley rats. Tjahjono K*, Setyawati AN*, Novyanto R**, Angelo M**, Pratama MFR**, Dinayanti T** *Department of Biochemistry, Faculty of Medicine Diponegoro University, Semarang, Indonesia **Faculty of Medicine Diponegoro University, Semarang, Indonesia Background: WHO has estimated CVD Method: This was an experiment with pre and - (Cerebrovascular disease) by 2010 to be the most post randomized controlled group design, using leading death factor worldwide. This reflects a hypercholesterolemic male Sprague-dawley rats, significant change in diet habits, physical activity which were divided into 4 groups, the first group levels, and tobacco consumption worldwide. High was placebo (P) with normal feeding, the others blood pressure, high blood cholesterol, overweight were with levelled-up additional feeding of 125 and obesity - and the chronic disease of type 2 mg/Kg weight/day (T1), 250 mg/Kg weight/day diabetes are among the major biological risk (T2), and 500 mg/Kg weight/day (T3). Total factors for CVD. Hibiscus sabdariffa is traditionally cholesterol and HDL were analyzed with GPO-PAP believed to improve hyperlipidemic condition. This method and triglyceride was with Friedewald study was conducted to look for the hypolipidemic method effect of Hibiscus sabdariffa and the dose given difference outcome. Table. Mean pre-and post-treatment values of lipid profile. Result: Post hoc LSD analysis showed that the total cholesterol, LDL and triglyceride were with significant difference between pre and post- experimental paired groups [total cholesterol; LDL; triglyceride, subsequently with p: 0.000; p: 0,000; p:0,000]. There was also a significant increment on HDL cholesterol (p: 0.000). Discussion: The hypolipidemic of Hibiscus sabdariffa between pre and post- experimental is assumed due to pectin, niacin, anthosianin, dan β-sitosterol containment. These active H. sabdariffa flower compounds have been studied and concluded to increase lipoprotein lipase activity, bile-acid bound, and catalytic activity rate of cholesterol which may explain the hypolipidemic effect of Hibiscus sabdariffa. Keyword: Hibiscus sabdariffa, hypercholesterolemia, lipid profile Reference: 1. C.M. Gurrola-Dı´az, et. al. Effect of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid Conclusion: The hypolipidemic of Hibiscus profiles of patients with Metabolic Syndrome (MeSy). Phytomedicine.17, 500–5. sabdariffa between pre and post- experimental is 2. Chen CC, et.al. Hibiscus sabdariffa extract inhibits the assumed due to pectin, niacin, anthosianin, dan β- development of atherosclerosis in sitosterol containment. These active compounds cholesterol-fedrabbits.J.Agric.FoodChem.51,5472–5477 have been studied and concluded to increase lipoprotein lipase activity, bile-acid bound, and Presented in the Indonesian Medical Doctor catalytic activity rate of cholesterol which may Nutrition Society) National Congress, explain the hypolipidemic effect of Hibiscus Semarang, October 15-17th, 2010 sabdariffa.