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Empty Scrotum
Dr Tarig Hassan
Tutorial
Where does the testes start to develop?
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EMPTY SCROTUM
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When does the testes start to develop?
Testes begin to develop
inside the ? by the
? month IU, and
descend into the scrotum
during ? to ? mth of
fetal development.
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 Iliac fossa 3rd-5th month
 Deep inguinal ring 7th month
 Superficial ring 8th month
 Scrotum 9th month
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Factors which affect descent:
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What are the factors which affect descent
Factors which affect descent:
1- shortening of the gubernaculum.
2- hormonal factors:testesterone,HGnh
3- Insulin-Like 3 (INSL3)
4- differential growth of body wall in
relation to a relatively immobile
gubernaculum.
5- increased intra-abdominal pressure
Others???
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Theories
Risk Factors for incomplete descent?
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Risk Factors for incomplete descent?
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 Premature birth.
 Low birth weight.
 Family history. ?? Genetic.
 Abdominal wall defect.
 Alcohol use & Cigarette smokingby the mother.
 Assisted reproduction (IVF)
 Parents' exposure to toxins??? Pesticides ??
 Down syndrome.
Gurney Nat Rev Urol. 2017
DESCENT OF THE TESTES
Complete by 1 month
post birth
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70% of full term crypto-orchid
testes and up to 95% of
premature crypto-orchid testes will
spontaneously descend by 1year
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N B
PRESENTATION
38yrs Mother advice?
Newborn 4 month
Bilateral impalpable testes.
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1
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1
? ? ?
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PRESENTATION
22yrs M. 8 hrs.
painful right inguinal swelling.
nausea, vomiting.
O/E: tender Rt. Inguinal swelling.
Rt empty scrotum.
Investigations.
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2
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Exploration surgically
2
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? ? ?
PRESENTATION
24 yrs M, vague RIF pain??
for 2 mths.
Right iliac fossa mass.
Investigations.
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PRESENTATION
Surgical Exploration.
Seminoma.
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Palpable testes.
Non-palpable testes.
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Undescended testes. 95%
Ectopic testes. <5%
Retractile testes.
Atrophic / Vanishing
ascending testes. <2%
Anorchia.
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UNDESCENDED TESTES
How common??
Right > Left,
25% bilateral.
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UNDESCENDED TESTES
Incidence:
 3 % in full term infant.
 1 % by one year.
 30% in premature infant.
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UNDESCENDED TESTES
Right > Left,
25% bilateral.
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AETIOLOGY:
Several theories:
 Reduced intra-abdominal pressure.
cong abdominal wall defects, hernias.
 Abnormality of the gubernaculum.
 Endocrine abnormality
HCGH, Testesterone, LH.
 Familial, chromosomal, multifactorial.
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LOCATION
 Palpable or non-palpable

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COMPLICATIONS
Higher incidence of:
Cancer. 30 times increased risk.
(NOT AFFECTED BY ORCHIOPEXY).
Infertility.
70% in bilateral.
Testicular torsion.
Trauma.
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COMPLICATIONS
Associations
 Inguinal hernia: patent PV.
 Hypospadias.
 Psychological effects.
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EVALUATION
History. Prematurity, FH.
Physical examination:
- warm room, quiet
- child.
- check Wt. for GA.
 Scrotal development. Penile development +?
 Contralateral hypertrophy or atrophy.
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UNDESCENDED TESTES
for non-palpable
-Ultrasonography.
-CT-scan.
-MRI.
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Investigations
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UNDESCENDED TESTES
Laparoscopy:
Diagnosis
+ management
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UNDESCENDED TESTES
Management:
Rationale:
limiting complications.
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UNDESCENDED TESTES
Management:
Hormonal therapy: ???
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UNDESCENDED TESTES
Management:
Surgery:
Operative treatment:
WHEN ???
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UNDESCENDED TESTES
Procedure:
orchidopexy
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UNDESCENDED TESTES
 Early orchidopexy may improve fertility
 No evidence that it reduces risk of malignancy
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ECTOPIC TESTES
 Less < 5 %
 descended properly from the abdomen
.. but mis-directed outside the external
inguinal to an abnormal position.
 presumably due to an abnormally
positioned distal extension of the
gubernaculum.
 function normally.
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Incompletely
descended Ectopic
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RETRACTILE TESTES
 ? Hyperactive cremasteric reflex.
 normal size & consistency
 scrotum well developed.
 remains in scrotum with manipulation.
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ASCENDING TESTES ?
- Trauma.
- Previous inguinal surgery.
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- Trauma.
- Infection.
- Previous inguinal surgery.
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