Equilibrium
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Equilibrium reactions can be categorized as fast, slow, or reversible reactions depending on their nature and experimental conditions. A reaction at equilibrium has reached a balance point where the rates of the forward and reverse reactions are equal. The position of equilibrium can be influenced by changing conditions like concentration, temperature, or pressure through Le Chatelier's principle.
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can remain in the gastric region for delayed periods. They significantly increase the gastric
residence time of medication, thereby enhance bioavailability, improves patient compliance by
reducing dosing frequency, lessen the medication waste, enhance retention of medication which
solubilize only in stomach, enhance solubility for medications that are less soluble at a higher pH
environment. The present review preparation methods, characterization, advantages,
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formulated as microballoons are discussed.
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Oral controlled release dosage forms face several physiological restriction like inability to retain and position the controlled drug delivery system within the targeted region of the gastrointestinal tract (GIT) due to fluctuation in gastric emptying. This results in nonuniform absorption pattern, inadequate medication release and shorter residence time of the dosage form in the stomach. As the fallout of this episode there is inadequate absorption of the drug having absorption window predominantly, in the upper area of GIT. These contemplations have provoked to the development of oral controlled release dosage forms with gastroretentive properties. Microsponge hold certification as one of the potential approaches for gastric retention. Microsponge are porous spherical empty particles without core and can remain in the gastric region for delayed periods. They significantly increase the gastric residence time of medication, thereby enhance bioavailability, improves patient compliance by reducing dosing frequency, lessen the medication waste, enhance retention of medication which solubilize only in stomach, enhance solubility for medications that are less soluble at a higher pH environment. In the present review method of preparation, characterization, advantages, disadvantages and applications of floating microsponge are discussed. Please citeDesign, Development, Evaluation and Optimization of Microballoons of Telmisartan
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Abstract: In present study an attempt was made to prepare microballoons of
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using polymers like Ethyl cellulose to extend the drug release for about 12 hours in
the upper GIT, which may result in enhanced absorption and there by improved
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optimized formulation. DP4 batch was further used for process optimization. The
process optimization was carried out at three different stirring speeds i.e. 1300,
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spherical shape of microballoons without formation of flakes. Optimized batch
DP13 was evaluated for Zeta Potential, Particle Size Distribution which show -
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charged for stability and were placed in glass vials container and stored at ICH
storage condition (2属C - 4属C Refrigeration condition , 30 賊 2属C / 60% 賊 5% RH ,
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- Using smooth, cleanable materials like stainless steel, glass or epoxy paint for floors, walls and ceilings.
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Oral controlled release dosage forms face several physiological restriction like inability to retain
and position the controlled drug delivery system within the targeted region of the gastrointestinal
tract (GIT) due to fluctuation in gastric emptying. This results in non uniform absorption
pattern, inadequate medication release and shorter residence time of the dosage form in the
stomach. As the fallout of this episode there is inadequate absorption of the drug having
absorption window predominantly, in the upper area of GIT. These contemplations have
provoked to the development of oral controlled release dosage forms with gastroretentive
properties. Microballoons (Hollow microspheres) hold certification as one of the potential
approaches for gastric retention. Microballoons are spherical empty particles without core and
can remain in the gastric region for delayed periods. They significantly increase the gastric
residence time of medication, thereby enhance bioavailability, improves patient compliance by
reducing dosing frequency, lessen the medication waste, enhance retention of medication which
solubilize only in stomach, enhance solubility for medications that are less soluble at a higher pH
environment. The present review preparation methods, characterization, advantages,
disadvantages, mechanism of drug release from microballoons, applications and list of the drugs
formulated as microballoons are discussed.
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Oral controlled release dosage forms face several physiological restriction like inability to retain and position the controlled drug delivery system within the targeted region of the gastrointestinal tract (GIT) due to fluctuation in gastric emptying. This results in nonuniform absorption pattern, inadequate medication release and shorter residence time of the dosage form in the stomach. As the fallout of this episode there is inadequate absorption of the drug having absorption window predominantly, in the upper area of GIT. These contemplations have provoked to the development of oral controlled release dosage forms with gastroretentive properties. Microsponge hold certification as one of the potential approaches for gastric retention. Microsponge are porous spherical empty particles without core and can remain in the gastric region for delayed periods. They significantly increase the gastric residence time of medication, thereby enhance bioavailability, improves patient compliance by reducing dosing frequency, lessen the medication waste, enhance retention of medication which solubilize only in stomach, enhance solubility for medications that are less soluble at a higher pH environment. In the present review method of preparation, characterization, advantages, disadvantages and applications of floating microsponge are discussed. Please citeDesign, Development, Evaluation and Optimization of Microballoons of Telmisartan
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油
Abstract: In present study an attempt was made to prepare microballoons of
Telmisartan by emulsion solvent diffusion technique for sustained delivery by
using polymers like Ethyl cellulose to extend the drug release for about 12 hours in
the upper GIT, which may result in enhanced absorption and there by improved
bioavailability. Formulation optimization of Telmisartan loaded microballoons was
carried out by using different concentration of Polyvinyl alcohol (PVA) and Ethyl
cellulose. Total 9 batches were formulated. All 9 batches were evaluated for
entrapment efficiency (EE) and buoyancy. Among all batches DP4 shows
maximum entrapment efficiency (EE) and buoyancy and was considered as
optimized formulation. DP4 batch was further used for process optimization. The
process optimization was carried out at three different stirring speeds i.e. 1300,
1500 and 1700 rpm for three different stirring time period i.e. 1hr, 2hr and 3 hr and
another 9 batches were formulated. Out of all the batches DP13 showed the
spherical shape of microballoons without formation of flakes. Optimized batch
DP13 was evaluated for Zeta Potential, Particle Size Distribution which show -
41.8mV and 1.344 亮m particle size, SEM, XRD Analysis. Batch DP13 was
charged for stability and were placed in glass vials container and stored at ICH
storage condition (2属C - 4属C Refrigeration condition , 30 賊 2属C / 60% 賊 5% RH ,
40 賊 2属C / 75% 賊 5% RH ) for a period of 30 days. The samples were analyzed for
physical appearance, buoyancy and for the drug release after 30 days. After 1
months samples were withdrawn and microballoons showed no change in physical
appearances, buoyancy and drug release, which indicate that the microballoons
were stable.
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The document discusses the design of aseptic areas for sterile product production. It outlines several key aspects of aseptic area design including:
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- Using smooth, cleanable materials like stainless steel, glass or epoxy paint for floors, walls and ceilings.
- Fitting doors and windows flush to walls and maintaining positive air pressure and airflow.
- Supplying high-efficiency filtered air through HEPA filters and laminar airflow benches.
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One Click RFQ Cancellation in Odoo 18 - Odoo 際際滷sCeline George
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In this slide, well discuss the one click RFQ Cancellation in odoo 18. One-Click RFQ Cancellation in Odoo 18 is a feature that allows users to quickly and easily cancel Request for Quotations (RFQs) with a single click.Full-Stack .NET Developer Interview Questions PDF By ScholarHat
Full-Stack .NET Developer Interview Questions PDF By ScholarHatScholarhat
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Full-Stack .NET Developer Interview Questions PDF By ScholarHatHow to create security group category in Odoo 17
How to create security group category in Odoo 17Celine George
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This slide will represent the creation of security group category in odoo 17. Security groups are essential for managing user access and permissions across different modules. Creating a security group category helps to organize related user groups and streamline permission settings within a specific module or functionality.
Odoo 18 Accounting Access Rights - Odoo 18 際際滷s
Odoo 18 Accounting Access Rights - Odoo 18 際際滷sCeline George
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In this slide, well discuss on accounting access rights in odoo 18. To ensure data security and maintain confidentiality, Odoo provides a robust access rights system that allows administrators to control who can access and modify accounting data. Equilibrium
- 1. Equilibrium
- 2. Introduction
- 6. Depending on the nature of reaction and experimental condition, the reaction may be fast or slow. Equilibrium reaction can be divided into following three categories:
- 43. x