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This document summarizes a computational simulation project to assess the performance of tissue engineered aortic valves in pediatric patients. The project aims to build high-fidelity simulations of aortic valve geometry, mechanics, and function using finite element analysis software. Validation of the simulations will involve mechanical testing and use of a heart valve bioreactor. The simulations intend to help predict how tissue engineered valves may perform as an alternative to surgical replacement in growing children.

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Computational Simulation to Assess Aortic Valve Performance Sourav PatnaikBiomedical EngineeringABE and CAVSMississippi State University
MotivationsA tissue engineered valve with growth potential is much needed in pediatric patients who need heart valve replacement.High fidelity computational simulation would help us better predict the performance of tissue engineered valve.
Project PlanAortic valve geometry and meshingMechanical properties of valve leaflet, aorta, and root Determine constitutive relations ABAQUS simulationValidation
Biaxial Behavior of Leaflets after Different Treatment
Bottom ViewTop viewComplete ConduitSingle LeafletSection View
Thubrikar, M. J., 1980. Aortic Valve.
Target goalFE Free EdgeCD Circum. directionRD Radial DirectionA line of attachment to aortaL- load bearing surfaceC- line of coaptationR- redundant (coaptation) surfaceThubrikar, M. J., 1980. Aortic Valve.
Future StudiesMechanical testing of aorta and rootFind the best constitutive models for leaflet, aorta, and rootPerfect geometry and meshingLearn ABAQUS ValidationClemson University Heart Valve bioreactor (Dr. Siminonescu)

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Feb Monthly meeting

  • 1. Computational Simulation to Assess Aortic Valve Performance Sourav PatnaikBiomedical EngineeringABE and CAVSMississippi State University
  • 2. MotivationsA tissue engineered valve with growth potential is much needed in pediatric patients who need heart valve replacement.High fidelity computational simulation would help us better predict the performance of tissue engineered valve.
  • 3. Project PlanAortic valve geometry and meshingMechanical properties of valve leaflet, aorta, and root Determine constitutive relations ABAQUS simulationValidation
  • 4. Biaxial Behavior of Leaflets after Different Treatment
  • 5. Bottom ViewTop viewComplete ConduitSingle LeafletSection View
  • 6. Thubrikar, M. J., 1980. Aortic Valve.
  • 7. Target goalFE Free EdgeCD Circum. directionRD Radial DirectionA line of attachment to aortaL- load bearing surfaceC- line of coaptationR- redundant (coaptation) surfaceThubrikar, M. J., 1980. Aortic Valve.
  • 8. Future StudiesMechanical testing of aorta and rootFind the best constitutive models for leaflet, aorta, and rootPerfect geometry and meshingLearn ABAQUS ValidationClemson University Heart Valve bioreactor (Dr. Siminonescu)