Fertilization

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national institute of genetics and biotechnology of Iran (NIGEB)

fertilization only occur when oocyte and sperm are activated .what happens when an activated sperm is able to penetrate ovum membrane .blocking the entrance of other sperms has a specific mechanism explained in this power point

Health & Medicine

Fertilization
process
Presented by : Afagh Bapirzadeh
Instructor & Advisor :Dr. Behrouz Aghdam

Syllables of presentation
‫مطالب‬ ‫رئوس‬
1. Sperm Formation & Structure
2. Ovum Formation & Structure
3. Fertilization Process
4. Sperm Activation
5. Ovum Activation
6. Blockage Of Polyspermy
7. Calcium Ion Role In Fertilization
8. Polyspermy And Associated Abnormalities
.1‫اسپرم‬ ‫ساختار‬ ‫و‬ ‫گیری‬ ‫شکل�Ĭ
.2‫تخمک‬ ‫ساختار‬ ‫و‬ ‫گیری‬ ‫شکل�Ĭ
.3‫لقاح‬ ‫روند‬
.4‫اسپرم‬ ‫شدن‬ ‫فعال‬
.5‫تخمک‬ ‫شدن‬ ‫فعال‬
.6‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬)‫اسپرم‬ ‫چند‬ ‫ورود‬(
.7‫لقاح‬ ‫در‬ ‫کلسیم‬ ‫یون‬ ‫نقش‬
.8‫مرتبط‬ ‫ناهنجاریهای‬ ‫و‬ ‫اسپرمی‬ ‫پلی‬

Sperm Structure
‫اسپرم‬ ‫ساختار‬
‫دم‬
‫پالسمایی‬ ‫غشای‬
‫گردن‬
‫سر‬
‫میانی‬ ‫ی‬ ‫تکه‬
‫هسته‬
‫آکروزوم‬
‫میتوکندری‬
(‫مارپیچی‬ ‫شکل�Ĭ ‫با‬)
 Head
 Middle piece
Mitochondrion
 Tail plasma membrane
Nucleus
Acrosome

Ovum Structure
‫تخمک‬ ‫ساختار‬
‫پلوسیدا‬ ‫زونا‬
‫پالسمایی‬ ‫غشای‬
‫هسته‬
‫سیتوپالس‬‫م‬
‫فولیکولی‬ ‫سلولهای‬
‫رادیاتا‬ ‫کرونا‬

Sperm Activation
‫اسپرم‬ ‫سازی‬ ‫فعال‬
• Capacitation
• Acrosome Reaction

Oocyte Activation
‫تخمک‬ ‫شدن‬ ‫فعال‬
1. Cortical reaction to block against
other sperm cells
2. Activation of egg metabolism
3. Reactivation of meiosis
4. DNA synthesis

Normal Fertilization Versus Abnormal Fertilization
‫طبیعی‬ ‫غیر‬ ‫لقاح‬ ‫با‬ ‫مقایسه‬ ‫در‬ ‫طبیعی‬ ‫لقاح‬
‫طبیعی‬

Polyspermy Blockage Mechanisms
‫مکانی‬‫س‬‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬ ‫های‬ ‫م‬
Slow Blockage Of Polyspermy
(‫کند‬ ‫ی‬ ‫شیوه‬ ‫به‬ ‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬)
Involves zonal inhibiting proteins
(‫باشد‬ ‫می‬ ‫زونال‬ ‫ی‬ ‫جلوگیرنده‬ ‫های‬ ‫پروتیین‬ ‫شامل‬)
Fast Blockage Of Polyspermy
(‫سریع‬ ‫ی‬ ‫شیوه‬ ‫به‬ ‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬)
Membrane depolarization
(‫غشایی‬ ‫شدن‬ ‫دپالریزه‬)

Slow Blockage Of Polyspermy
‫کند‬ ‫ی‬ ‫شیوه‬ ‫به‬ ‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬

Fast Blockage Of Polyspermy
‫سریع‬ ‫ی‬ ‫شیوه‬ ‫به‬ ‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬
• Membrane
Depolarization

Calcium Ion Role In Fertilization
‫لقاح‬ ‫در‬ ‫کلسیم‬ ‫یون‬ ‫نقش‬
1. Oocyte activation
2. Stimulates cortical reaction

Polyspermy And Associated Abnormalities
‫مرتبط‬ ‫ناهنجاریهای‬ ‫و‬ ‫اسپرمی‬ ‫پلی‬
Molar pregnancies
• Partial molar pregnancies
• Complete molar pregnancies

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Fertilization

1. Fertilization process Presented by : Afagh Bapirzadeh Instructor & Advisor :Dr. Behrouz Aghdam

2. Syllables of presentation ‫مطالب‬ ‫رئوس‬ 1. Sperm Formation & Structure 2. Ovum Formation & Structure 3. Fertilization Process 4. Sperm Activation 5. Ovum Activation 6. Blockage Of Polyspermy 7. Calcium Ion Role In Fertilization 8. Polyspermy And Associated Abnormalities .1‫اسپرم‬ ‫ساختار‬ ‫و‬ ‫گیری‬ ‫شکل�Ĭ .2‫تخمک‬ ‫ساختار‬ ‫و‬ ‫گیری‬ ‫شکل�Ĭ .3‫لقاح‬ ‫روند‬ .4‫اسپرم‬ ‫شدن‬ ‫فعال‬ .5‫تخمک‬ ‫شدن‬ ‫فعال‬ .6‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬)‫اسپرم‬ ‫چند‬ ‫ورود‬( .7‫لقاح‬ ‫در‬ ‫کلسیم‬ ‫یون‬ ‫نقش‬ .8‫مرتبط‬ ‫ناهنجاریهای‬ ‫و‬ ‫اسپرمی‬ ‫پلی‬

3. Sperm Formation ‫اسپرم‬ ‫گیری‬ ‫شکل�Ĭ

4. Sperm Structure ‫اسپرم‬ ‫ساختار‬ ‫دم‬ ‫پالسمایی‬ ‫غشای‬ ‫گردن‬ ‫سر‬ ‫میانی‬ ‫ی‬ ‫تکه‬ ‫هسته‬ ‫آکروزوم‬ ‫میتوکندری‬ (‫مارپیچی‬ ‫شکل�Ĭ ‫با‬)  Head  Middle piece Mitochondrion  Tail plasma membrane Nucleus Acrosome

5. Ovum Formation ‫تخمک‬ ‫گیری‬ ‫شکل�Ĭ

6. Ovum Structure ‫تخمک‬ ‫ساختار‬ ‫پلوسیدا‬ ‫زونا‬ ‫پالسمایی‬ ‫غشای‬ ‫هسته‬ ‫سیتوپالس‬‫م‬ ‫فولیکولی‬ ‫سلولهای‬ ‫رادیاتا‬ ‫کرونا‬

7. Fertilization process

8. Sperm Activation ‫اسپرم‬ ‫سازی‬ ‫فعال‬ • Capacitation • Acrosome Reaction

9. Oocyte Activation ‫تخمک‬ ‫شدن‬ ‫فعال‬ 1. Cortical reaction to block against other sperm cells 2. Activation of egg metabolism 3. Reactivation of meiosis 4. DNA synthesis

10. Fertilization ‫لقاح‬

11. Normal Fertilization Versus Abnormal Fertilization ‫طبیعی‬ ‫غیر‬ ‫لقاح‬ ‫با‬ ‫مقایسه‬ ‫در‬ ‫طبیعی‬ ‫لقاح‬ ‫طبیعی‬

12. Polyspermy Blockage Mechanisms ‫مکانی‬‫س‬‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬ ‫های‬ ‫م‬ Slow Blockage Of Polyspermy (‫کند‬ ‫ی‬ ‫شیوه‬ ‫به‬ ‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬) Involves zonal inhibiting proteins (‫باشد‬ ‫می‬ ‫زونال‬ ‫ی‬ ‫جلوگیرنده‬ ‫های‬ ‫پروتیین‬ ‫شامل‬) Fast Blockage Of Polyspermy (‫سریع‬ ‫ی‬ ‫شیوه‬ ‫به‬ ‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬) Membrane depolarization (‫غشایی‬ ‫شدن‬ ‫دپالریزه‬)

14. Slow Blockage Of Polyspermy ‫کند‬ ‫ی‬ ‫شیوه‬ ‫به‬ ‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬

15. Fast Blockage Of Polyspermy ‫سریع‬ ‫ی‬ ‫شیوه‬ ‫به‬ ‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬ • Membrane Depolarization

16. Calcium Ion Role In Fertilization ‫لقاح‬ ‫در‬ ‫کلسیم‬ ‫یون‬ ‫نقش‬ 1. Oocyte activation 2. Stimulates cortical reaction

17. Polyspermy And Associated Abnormalities ‫مرتبط‬ ‫ناهنجاریهای‬ ‫و‬ ‫اسپرمی‬ ‫پلی‬ Molar pregnancies • Partial molar pregnancies • Complete molar pregnancies

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Fertilization

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