際際滷

際際滷Share a Scribd company logo

Folding molecular biology 1

Download as PPT, PDF
Emmanuel Diaz
Emmanuel Diaz

This document discusses two recent discoveries that could lead to improved cancer treatments: 1) the discovery of a protein called XPD that acts as a "scanner" to recognize and mark locations of damaged DNA, and 2) the identification of early replicating fragile sites (ERFSs) in DNA that are particularly vulnerable to damage and associated with a type of blood cancer. These findings provide new insights into DNA vulnerability and damage recognition that may help enhance cancer therapies by directly manipulating DNA to make it more resistant to damage and tumors.

1 of 20
A SCANNER FOR HEREDITARY DEFECTS NEW POSSIBILITIES IN GENETIC DAMAGE RECOGNITION FOR IMPROVEMENT CANCER TREATMENT AND DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA REGIONS COULD LEAD BETTER CANCER TREATMENTS . MOLECULAR BIOLOGY EMMANUEL SNCHEZ DAZ SECOND YEAR MEDICAL STUDENT MEDELLN 2013
Folding molecular biology 1
Folding molecular biology 1
INTRODUCTION. DNA is very susceptible to damages because of the permanent exposure to several mutagenic factors. In addition, DNA has some fragile sites which makes it more vulnerable to damage especially in early stages of the division cell cycle . The recognition of a new protein in charge of repairing DNA damages (first new), and the locations where DNA is fragile (Second new) are advances that provides new tools for the cancer treatment.
A SCANNER FOR HEREDITARY DEFECTS: NEW POSSIBILITIES IN GENETIC DAMAGE RECOGNITION FOR IMPROVING CANCER TREATMENT. Our genetic material is permanently under the effects of several factors which may cause damages in the sequence that usually are repaired immediately by molecular control systems as p53 protein.
A SCANNER FOR HEREDITARY DEFECTS: NEW POSSIBILITIES IN GENETIC DAMAGE RECOGNITION FOR IMPROVING CANCER TREATMENT. Scientists discovered a specially function of XPD protein in the recognition of these specific damaged locations in the sequences facilitating it卒s eventually reparation.
A SCANNER FOR HEREDITARY DEFECTS: NEW POSSIBILITIES IN GENETIC DAMAGE RECOGNITION FOR IMPROVING CANCER TREATMENT. The XPD protein glides among the bases in search of damages in the sequence , scientists describe it as a scanner. When the protein recognizes a damaged site, it stops and marks the location for its posterior reparation. The protein is also involved in processes as the cell cycle, genic expression, and others.
A SCANNER FOR HEREDITARY DEFECTS: NEW POSSIBILITIES IN GENETIC DAMAGE RECOGNITION FOR IMPROVING CANCER TREATMENT. While repairing DNA, XPD protein protects the tissues health from damages in the genetic material, but it also diminishes the activity of some chemotherapeutic drugs.
OP NION.
DISCOVERY OF NEW CLASS OF DAMAGE PRONE DNA REGIONS COULD LEAD BETTER CANCER TRETMENTS. Cancer could comes from a damage in a specific locations in DNA sequence, these sequences are thought to be more vulnerable to damage. Scientists discovered the relationship between particular fragile DNA sites and an specific blood cancer called cell B lymphoma.
DISCOVERY OF NEW CLASS OF DAMAGE PRONE DNA REGIONS COULD LEAD BETTER CANCER TRETMENTS. The DNA damage could take place in different stages of the cell cycle, but its more common to occur during the early phases of the replication, before division. There are locations in the DNA sequence that are more vulnerable to DNA damages as the very repetitive sequences where the DNA could break easily.
DISCOVERY OF NEW CLASS OF DAMAGE PRONE DNA REGIONS COULD LEAD BETTER CANCER TRETMENTS. Lymphocytes are cells with a high division rate, thats the reason why they are more vulnerable suffering damages during replication, in addition during the non replicative stage of the cell cycle, this cells are very vulnerable to breaking in the strand by the enzyme AID who causes collateral damages in the genome. The AID have no activity in several mutations associated in cell B lymphoma.
DISCOVERY OF NEW CLASS OF DAMAGE PRONE DNA REGIONS COULD LEAD BETTER CANCER TRETMENTS. The scientists discovered a new kind of fragile sites called early replicating fragile sites (ERFSs) , the DNA damage at ERFSs occurs during early stages of replication. These sites have a high relationship with cell B lymphoma.
OP NION.
MEDICAL UTILITY. Cancer is a condition that concerns to all the medical sciences since its discovering. This disease has a particular etiology located in DNA sequence which is constantly attached by several factors that could affect the genome stability. In addition DNA has different vulnerable sites.
MEDICAL UTILITY. Advances allow us to recognize vulnerable locations of DNA and proteins involved in DNA damage reparation, this could lead us to improve the treatments against cancer and furthermore to manipulate the DNA sequence to make it invincible
MEDICAL UTILITY. The actual cancer treatments have a lot of secondary effects, diminishing the patients life quality, if we as scientists could intervene directly in the DNA sequence, we could eventually delete the uncomfortable therapy's and get better results in the battle against cancer
MEDICAL UTILITY. If we have the mechanisms to recognize the exact locations where DNA is damaged and mark this place, we could make quicker processes and improve the economical performance, reducing costs and improving the treatments.
Folding molecular biology 1
THANKS!!!

More Related Content

Folding molecular biology 1

  • 1. A SCANNER FOR HEREDITARY DEFECTS NEW POSSIBILITIES IN GENETIC DAMAGE RECOGNITION FOR IMPROVEMENT CANCER TREATMENT AND DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA REGIONS COULD LEAD BETTER CANCER TREATMENTS . MOLECULAR BIOLOGY EMMANUEL SNCHEZ DAZ SECOND YEAR MEDICAL STUDENT MEDELLN 2013
  • 4. INTRODUCTION. DNA is very susceptible to damages because of the permanent exposure to several mutagenic factors. In addition, DNA has some fragile sites which makes it more vulnerable to damage especially in early stages of the division cell cycle . The recognition of a new protein in charge of repairing DNA damages (first new), and the locations where DNA is fragile (Second new) are advances that provides new tools for the cancer treatment.
  • 5. A SCANNER FOR HEREDITARY DEFECTS: NEW POSSIBILITIES IN GENETIC DAMAGE RECOGNITION FOR IMPROVING CANCER TREATMENT. Our genetic material is permanently under the effects of several factors which may cause damages in the sequence that usually are repaired immediately by molecular control systems as p53 protein.
  • 6. A SCANNER FOR HEREDITARY DEFECTS: NEW POSSIBILITIES IN GENETIC DAMAGE RECOGNITION FOR IMPROVING CANCER TREATMENT. Scientists discovered a specially function of XPD protein in the recognition of these specific damaged locations in the sequences facilitating it卒s eventually reparation.
  • 7. A SCANNER FOR HEREDITARY DEFECTS: NEW POSSIBILITIES IN GENETIC DAMAGE RECOGNITION FOR IMPROVING CANCER TREATMENT. The XPD protein glides among the bases in search of damages in the sequence , scientists describe it as a scanner. When the protein recognizes a damaged site, it stops and marks the location for its posterior reparation. The protein is also involved in processes as the cell cycle, genic expression, and others.
  • 8. A SCANNER FOR HEREDITARY DEFECTS: NEW POSSIBILITIES IN GENETIC DAMAGE RECOGNITION FOR IMPROVING CANCER TREATMENT. While repairing DNA, XPD protein protects the tissues health from damages in the genetic material, but it also diminishes the activity of some chemotherapeutic drugs.
  • 10. DISCOVERY OF NEW CLASS OF DAMAGE PRONE DNA REGIONS COULD LEAD BETTER CANCER TRETMENTS. Cancer could comes from a damage in a specific locations in DNA sequence, these sequences are thought to be more vulnerable to damage. Scientists discovered the relationship between particular fragile DNA sites and an specific blood cancer called cell B lymphoma.
  • 11. DISCOVERY OF NEW CLASS OF DAMAGE PRONE DNA REGIONS COULD LEAD BETTER CANCER TRETMENTS. The DNA damage could take place in different stages of the cell cycle, but its more common to occur during the early phases of the replication, before division. There are locations in the DNA sequence that are more vulnerable to DNA damages as the very repetitive sequences where the DNA could break easily.
  • 12. DISCOVERY OF NEW CLASS OF DAMAGE PRONE DNA REGIONS COULD LEAD BETTER CANCER TRETMENTS. Lymphocytes are cells with a high division rate, thats the reason why they are more vulnerable suffering damages during replication, in addition during the non replicative stage of the cell cycle, this cells are very vulnerable to breaking in the strand by the enzyme AID who causes collateral damages in the genome. The AID have no activity in several mutations associated in cell B lymphoma.
  • 13. DISCOVERY OF NEW CLASS OF DAMAGE PRONE DNA REGIONS COULD LEAD BETTER CANCER TRETMENTS. The scientists discovered a new kind of fragile sites called early replicating fragile sites (ERFSs) , the DNA damage at ERFSs occurs during early stages of replication. These sites have a high relationship with cell B lymphoma.
  • 15. MEDICAL UTILITY. Cancer is a condition that concerns to all the medical sciences since its discovering. This disease has a particular etiology located in DNA sequence which is constantly attached by several factors that could affect the genome stability. In addition DNA has different vulnerable sites.
  • 16. MEDICAL UTILITY. Advances allow us to recognize vulnerable locations of DNA and proteins involved in DNA damage reparation, this could lead us to improve the treatments against cancer and furthermore to manipulate the DNA sequence to make it invincible
  • 17. MEDICAL UTILITY. The actual cancer treatments have a lot of secondary effects, diminishing the patients life quality, if we as scientists could intervene directly in the DNA sequence, we could eventually delete the uncomfortable therapy's and get better results in the battle against cancer
  • 18. MEDICAL UTILITY. If we have the mechanisms to recognize the exact locations where DNA is damaged and mark this place, we could make quicker processes and improve the economical performance, reducing costs and improving the treatments.