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Fructose metabolism in Liver

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Sunil Sahoo

This document presents a summary of fructose metabolism in the liver. It begins with an introduction stating that fructose is present in fruit juices and honey and comes primarily from sucrose in the diet, which is hydrolyzed to glucose and fructose in the intestine. Fructose is then absorbed into portal blood and transported to the liver. It then outlines the pathway of fructose metabolism in the liver and two disorders related to fructose metabolism: essential fructosuria and hereditary fructose intolerance. Finally, it discusses some of the biomedical importance of fructose metabolism, including its role as an energy source for spermatozoa and possible link to diabetes and cataract development

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A PRESENTATION ON METABOLISM OF FRUCTOSE IN LIVER Presented By : Sunil Kumar Sahoo Enrolment No-CUSB1703132020 First Semester, L.Sc.-553
CONTENTS INTRODUCTION PATHWAY OF FRUCTOSE METABOLISM DISORDERS RELATED TO ITS METABOLISM IMPORTANCE OF FRUCTOSE REFERENCE
INTRODUCTION- Fructose is present in fruit juices & honey. Chief dietary source is sucrose which is a disaccharide composed of glucose & fructose joined by 留(1,2) bond. Sucrose is hydrolysed in the intestine by the enzyme sucrase. Fructose is mostly absorbed in the small intestine through GLUT-5 transporter mediated faciliated transport & taken by portal blood to liver.
PATHWAY OF FRUCTOSE METABOLISM
DISORDERS RELATED TO FRUCTOSE METABOLISM Essential Fructosuria * Deficiency of the enzyme fructokinase. * Fructose is not converted to fructose-1-phosphate. * Excretion of fructose in urine. Hereditary Fructose intolerance * Deficiency of enzyme Aldolase-B. * Fructose-1-phosphate can not be converted to dihydroxy - acetone phosphate & glyceraldehyde so it accumulates. *Results in inhibition of fructokinase & impared clearance of fructose from the blood.
BIOMEDICAL IMPORTANCE OF FRUCTOSE Frutose is easily metabolized & a good source of energy. Seminal fluid is rich in fructose & spermatozoa utilizes fructose for energy. In diabetics , fructose metabolism through sorbitol pathway may account for the development of cataract.
Fructose metabolism in Liver

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Fructose metabolism in Liver

  • 1. A PRESENTATION ON METABOLISM OF FRUCTOSE IN LIVER Presented By : Sunil Kumar Sahoo Enrolment No-CUSB1703132020 First Semester, L.Sc.-553
  • 2. CONTENTS INTRODUCTION PATHWAY OF FRUCTOSE METABOLISM DISORDERS RELATED TO ITS METABOLISM IMPORTANCE OF FRUCTOSE REFERENCE
  • 3. INTRODUCTION- Fructose is present in fruit juices & honey. Chief dietary source is sucrose which is a disaccharide composed of glucose & fructose joined by 留(1,2) bond. Sucrose is hydrolysed in the intestine by the enzyme sucrase. Fructose is mostly absorbed in the small intestine through GLUT-5 transporter mediated faciliated transport & taken by portal blood to liver.
  • 4. PATHWAY OF FRUCTOSE METABOLISM
  • 5. DISORDERS RELATED TO FRUCTOSE METABOLISM Essential Fructosuria * Deficiency of the enzyme fructokinase. * Fructose is not converted to fructose-1-phosphate. * Excretion of fructose in urine. Hereditary Fructose intolerance * Deficiency of enzyme Aldolase-B. * Fructose-1-phosphate can not be converted to dihydroxy - acetone phosphate & glyceraldehyde so it accumulates. *Results in inhibition of fructokinase & impared clearance of fructose from the blood.
  • 6. BIOMEDICAL IMPORTANCE OF FRUCTOSE Frutose is easily metabolized & a good source of energy. Seminal fluid is rich in fructose & spermatozoa utilizes fructose for energy. In diabetics , fructose metabolism through sorbitol pathway may account for the development of cataract.