Genital Warts and Role of Imiquimod Cream
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Genital warts, caused by HPV, are prevalent among sexually active individuals, with imiquimod cream being an FDA-approved treatment for external genital and perianal HPV infections. Imiquimod demonstrates similar efficacy to cryotherapy and lower recurrence rates compared to other treatments, stimulating the immune response by activating toll-like receptors. It is recommended by European and CDC treatment guidelines for managing genital warts due to its effectiveness and lower incidence of irritation.
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Genital Warts and Role of Imiquimod Cream
- 1. Genital Warts & Role of IMIQUIMOD Cream Shuman Chandra Das A-Grade Pharmacist Dhaka, Bangladesh
- 2. Ref.: An armamentarium of wart treatments, Clinical Medicine & Research, Vol.4, Number:4:273-293 70% Sexually active women become infected with HPV during their lifetime.
- 3. HPV infection in men is most commonly presented as genital warts or condylomata (benign epithelial tumors) Ref.: Suzanne Albrecht, HPV in men: treatment and prevention strategies; US pharmacist, august 19, 2008.
- 5. Most Common Location of External Genital Warts Women Vulva, Perianal area Men Penile shaft, Perianal area Ref: Journal of Womens Health 2004. 13:265-271
- 6. Different destructive or ablative treatment modalities have the disadvantage of high recurrence rates due to an incomplete elimination of HPV infected cells around the visible lesions. Ref. : Br J Dermatol. 2007 Dec;157 Suppl 2:52-5
- 7. Imiquimod is an immunomodulating agent that was approved by the FDA in 1997 for treatment of external genital and perianal HPV infections for patients age 12 years and over. Ref.: Comprehensive Dermatologic Drug Therapy by Wolverton, 3rd Edition
- 8. Imiquimod has an efficacy similar to Cryotherapy and yields a low recurrence rate. Imiquimod is more effective than podophyllotoxin in treating women with external genital warts. Less mild-to- moderate irritation than with Imiquimod compare to podophyllin or cryotherapy in men & women Ref.: Andrews Diseases of the skin clinical dermatology, 10th Edition Imiquimod is a recommended drug
- 9. Imiquimod, a potent stimulator of the release of several proinflammatory cytokines that acts at least in part by activation of Toll-like receptors 7 & 8, is approved for patient-applied therapy treatment of genital warts. Ref.: Fitzpatricks Dermatology in General Medicine, 8th Edition Imiquimod is a recommended drug
- 12. Imiquimod Ensures less recurrence 50% 33%Cryotherapy 22%Surgical excision 8% Imiquimod Laser therapy Ref.: 1 & 3. Infect Dis Obstet Gynecol 2002;10:79-88, 2 & 4. International Journal of STD & AIDS 2008;19:441-444, 4. Imiquimod Clinical Efficacy
- 15. According to Europeanand CDCtreatment guidelines Imiquimod is Recommended for Genital Warts Ref: Journal of Womens Health 2004. 13:265-271
- 16. Imiclara (Imiquimod) Fights viral infection Releases cytokines: Interferon, TNF, IL Prevents virus multiply Stimulates immune cell Heals genital warts Acts as toll-like receptor-7 agonist Imiquimod Mechanism of Action Against Genital warts
- 17. Imiquimod Cream
- 18. Imiquimod Cream
- 20. Thank You Shuman Chandra Das A-Grade Pharmacist Dhaka, Bangladesh