Guide to Pharmacology in 2018 - Flash Presentation
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Dr. Simon D. Harding of the University of Edinburgh created a knowledge-base that connects immunology and pharmacology. The knowledge-base links immunological targets and ligands to cell types and diseases. It is part of the IUPHAR/BPS Guide to Pharmacology, an open database of drug targets and ligands including approved drugs. A new search tool allows searching of pharmacological information. Dr. Harding also aims to curate data on antimalarial compounds and their molecular targets in Plasmodium through the IUPHAR/MMV Guide to Malaria Pharmacology.
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1) Organization of drug targets into families and subclasses for easier browsing, and organization of ligands into related families and groups.
2) Ability to visualize ligand binding affinities across species through activity graphs.
3) SynPHARM database for finding ligand binding sequences that can be engineered into synthetic proteins.
4) Expanded content with over 1,700 drug targets, 9,000 ligands, and options to search or download data in various formats.IUPHAR Web Resources WDS Webinar
IUPHAR Web Resources WDS WebinarGuide to PHARMACOLOGY
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(First slide is recording of webinar). IUPHAR Web Resources, Simplifying Complexity for Medicine and Education. WDS Webinar#11 held on 28th February 2017.
IUPHAR (International Union of Basic and Clinical Pharmacology) has developed and is developing a series of web-based services for the Pharmacological Sciences, for education, and for drug discovery. These services enable the simplification and dissemination of highly complex datasets, via expert committees linked to ontologically-correct databases (e.g., the drug and receptor sites expressed by the human genome). This has also allowed IUPHARin connection with the main national pharmacological societies, particularly the British Pharmacological Societyto raise funds for curators and meetings. This simple model is open-ended and is being expanded to, for example, immunological targets and experimental protocols, and to educational projects.
Speakers: Michael Spedding, Adam Pawson, Steve Alexander, Joanna Sharman, Simon Harding, Jamie Davies, John Szarek and Lynn LeCountRecently uploaded (20)
(Journal Club) Focused ultrasound excites neurons via mechanosensitive calciu...
(Journal Club) Focused ultrasound excites neurons via mechanosensitive calciu...David Podorefsky, PhD
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Journal Club (2/11/21)
Focused ultrasound excites neurons via mechanosensitive calcium accumulation and ion channel amplification(Journal Club) - Sci-fate Characterizes the Dynamics of Gene Expression in Si...
(Journal Club) - Sci-fate Characterizes the Dynamics of Gene Expression in Si...David Podorefsky, PhD
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Journal Club (4/27/20)
Sci-fate Characterizes the Dynamics of Gene Expression in Single CellsImproving the Perturbation-Based Explanation of Deepfake Detectors Through th...
Improving the Perturbation-Based Explanation of Deepfake Detectors Through th...VasileiosMezaris
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Presentation of our paper, "Improving the Perturbation-Based Explanation of Deepfake Detectors Through the Use of Adversarially-Generated Samples", by K. Tsigos, E. Apostolidis and V. Mezaris. Presented at the AI4MFDD Workshop of the IEEE/CVF Winter Conference on Applications of Computer Vision (WACV 2025), Tucson, AZ, USA, Feb. 2025. Preprint and software available at http://arxiv.org/abs/2502.03957 https://github.com/IDT-ITI/Adv-XAI-Deepfakes(Journal Club) - RNA m6A regulates transcription via DNA demethylation and ch...
(Journal Club) - RNA m6A regulates transcription via DNA demethylation and ch...David Podorefsky, PhD
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Journal Club (11/8/22)
RNA m6A regulates transcription via DNA demethylation and chromatin accessibility
Electrical Quantities and Circuits | IGCSE Physics
Electrical Quantities and Circuits | IGCSE PhysicsBlessing Ndazie
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This extensive slide deck provides a detailed exploration of electrical quantities and circuits for IGCSE Physics. It covers key electrical quantities, including charge, current, voltage (potential difference), resistance, power, energy, electromotive force (EMF), and internal resistance. The presentation also explains series and parallel circuits, with in-depth discussions on Ohms Law, Kirchhoffs Laws, electrical components, circuit calculations, and practical applications. Packed with illustrative diagrams, worked examples, and exam-style questions, this resource is ideal for IGCSE students, teachers, and independent learners preparing for exams.ARepeatingFastRadioBurstSourceinaLow-luminosityDwarfGalaxy
ARepeatingFastRadioBurstSourceinaLow-luminosityDwarfGalaxyS辿rgio Sacani
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Wepresent the localizationandhostgalaxyofFRB20190208A, arepeatingsourceof fast radiobursts (FRBs) discoveredusingCHIME/FRB.Aspartof thePinpointingREpeatingChImeSourceswithEVNdishesrepeater localizationprogramon theEuropeanVLBINetwork (EVN),wemonitoredFRB20190208Afor 65.6hr at 1.4GHzanddetectedasingleburst,whichledtoitsverylongbaselineinterferometrylocalizationwith260mas uncertainty(2).Follow-upopticalobservationswiththeMMTObservatory(i25.7mag(AB))foundnovisible hostattheFRBposition.SubsequentdeeperobservationswiththeGranTelescopioCanarias,however,revealedan extremelyfaintgalaxy(r=27.32賊0.16mag),verylikely(99.95%)associatedwithFRB20190208A.Giventhe dispersionmeasureoftheFRB(580pccm3),eventhemostconservativeredshiftestimate( ~ z 0.83 max )implies TheAstrophysicalJournalLetters,977:L4(17pp),2024December10 https://doi.org/10.3847/2041-8213/ad8ce1 息2024.TheAuthor(s).PublishedbytheAmericanAstronomicalSociety. 30BantingFellow. 31McGillSpaceInstituteFellow. 32 FRQNTPostdoctoralFellow. Originalcontent fromthisworkmaybeusedunder theterms of theCreativeCommonsAttribution4.0licence.Anyfurther distributionofthisworkmustmaintainattributiontotheauthor(s)andthetitle of thework, journalcitationandDOI. 1The Astrophysical Journal Letters, 977:L4 (17pp), 2024 December 10 Hewitt et al. that this is the lowest-luminosity FRB host to date (108 Le), even less luminous than the dwarf host of FRB20121102A. We investigate how localization precision and the depth of optical imaging affect host association and discuss the implications of such a low-luminosity dwarf galaxy. Unlike the other repeaters with low-luminosity hosts, FRB 20190208A has a modest Faraday rotation measure of a few tens of rad m2, and EVN plus Very Large Array observations reveal no associated compact persistent radio source. We also monitored FRB20190208A for 40.4hr over 2yr as part of the Extragalactic Coherent Light from Astrophysical Transients repeating FRB monitoring campaign on the Nan巽ay Radio Telescope and detected one burst. Our results demonstrate that, in some cases, the robust association of an FRB with a host galaxy will require both high localization precision and deep optical follow-up. Unified Astronomy Thesaurus concepts: Radio bursts (1339); Radio transient sources (2008); Very long baseline interferometry (1769); Dwarf galaxies (416)Hormones and the Endocrine System | IGCSE Biology
Hormones and the Endocrine System | IGCSE BiologyBlessing Ndazie
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This IGCSE Biology presentation explores hormones and the endocrine system, explaining their role in controlling body functions. Learn about the differences between nervous and hormonal control, major endocrine glands, key hormones (such as insulin, adrenaline, and testosterone), and homeostasis. Understand how hormones regulate growth, metabolism, reproduction, and the fight-or-flight response. A perfect resource for Cambridge IGCSE students preparing for exams!PROTEIN DEGRADATION via ubiquitous pathaway
PROTEIN DEGRADATION via ubiquitous pathawayKaviya Priya A
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Protein degradation via ubiquitous pathway In general science, a ubiquitous pathway refers to a biochemical or metabolic pathway that is:
1. *Widely present*: Found in many different organisms, tissues, or cells.
2. *Conserved*: Remains relatively unchanged across different species or contexts.
Examples of ubiquitous pathways include:
1. *Glycolysis*: The process of breaking down glucose for energy, found in nearly all living organisms.
2. *Citric acid cycle (Krebs cycle)*: A key metabolic pathway involved in energy production, present in many cells.
3. *Pentose phosphate pathway*: A metabolic pathway involved in energy production and antioxidant defenses, found in many organisms.
These pathways are essential for life and have been conserved across evolution, highlighting their importance for cellular function and survival.
Science project class 10 Covid-19 Tuberculosis
Science project class 10 Covid-19 TuberculosisVEENAKSHI PATHAK
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Coronaviruses are a large family of
Viruses that are common
Throughout the world and can cause
Respiratory illness in people and
Animals.
Telescope equatorial mount polar alignment quick reference guide
Telescope equatorial mount polar alignment quick reference guidebartf25
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Telescope equatorial mount polar alignment quick reference guide. Helps with accurate alignment and improved guiding for your telescope. Provides a step-by-step process but in a summarized format so that the quick reference guide can be reviewed and the steps repeated while you are out under the stars with clear skies preparing for a night of astrophotography imaging or visual observing.Direct Gene Transfer Techniques for Developing Transgenic Plants
Direct Gene Transfer Techniques for Developing Transgenic PlantsKuldeep Gauliya
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This presentation will explain all the methods adopted for developing transgenic plant using direct gene transfer technique.Seminario- biologia molecular. Diapositivas
Seminario- biologia molecular. DiapositivasIsabelaRestrepo10
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Seminario Biolog鱈a Molecular
Mariana Zapata
Isabela Sep炭lveda Restrepo 
Sujay Rao Mandavilli public profile March 2025 - (2)
Sujay Rao Mandavilli public profile March 2025 - (2)Sujay Rao Mandavilli
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Sujay Rao Mandavilli public profile March 2025 - (2)(Journal Club) - Hydro-Seq enables contamination-free high throughput single-...
(Journal Club) - Hydro-Seq enables contamination-free high throughput single-...David Podorefsky, PhD
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Journal Club (11/26/19)
Hydro-Seq enables contamination-free high throughput single-cell RNA-sequencing for circulating tumor cellsBeyond Point Masses. IV. Trans-Neptunian Object Altjira Is Likely a Hierarchi...
Beyond Point Masses. IV. Trans-Neptunian Object Altjira Is Likely a Hierarchi...S辿rgio Sacani
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Dynamically studying trans-Neptunian object (TNO) binaries allows us to measure masses and orbits. Most of the known objects appear to have only two components, except (47171) Lempo, which is the single known hierarchical triple system with three similar-mass components. Though hundreds of TNOs have been imaged with high-resolution telescopes, no other hierarchical triples (or trinaries) have been found among solar system small bodies, even though they are predicted in planetesimal formation models such as gravitational collapse after the streaming instability. By going beyond the point-mass assumption and modeling TNO orbits as non-Keplerian, we open a new window into the shapes and spins of the components, including the possible presence of unresolved inner binaries. Here we present evidence for a new hierarchical triple, (148780) Altjira (2001 UQ18), based on non-Keplerian dynamical modeling of the two observed components. We incorporate two recent Hubble Space Telescope observations, leading to a 17 yr observational baseline. We present a new open-source Bayesian pointspread function fitting code called nPSF that provides precise relative astrometry and uncertainties for single images. Our non-Keplerian analysis measures a statistically significant (2.5) nonspherical shape for Altjira. The measured J2 is best explained as an unresolved inner binary, and an example hierarchical triple model gives the best fit to the observed astrometry. Using an updated non-Keplerian ephemeris (which is significantly different from the Keplerian predictions), we show that the predicted mutual event season for Altjira has already begun, with several excellent opportunities for observations through 2030.Biowaste Management and Its Utilization in Crop Production.pptx
Biowaste Management and Its Utilization in Crop Production.pptxVivek Bhagat
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Bio-waste management involves the collection, treatment, and recycling of organic waste to reduce environmental impact. Proper utilization in crop production includes composting, vermiculture, and biofertilizers, enhancing soil fertility and sustainability. This eco-friendly approach minimizes waste, improves crop yield, and promotes sustainable agriculture.WORKING AND APPLICATION OF LC-MS/MS 2025
WORKING AND APPLICATION OF LC-MS/MS 2025PSG College of Technology
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LC-MS/MS (Liquid Chromatography-Tandem Mass Spectrometry) is a powerful analytical tool for comparing innovator and biosimilar drugs. It ensures precise characterization, detecting structural variations, impurities, and post-translational modifications, ensuring biosimilar quality, efficacy, and regulatory compliance in pharmaceutical development.Neumann, Franz. - Behemoth [ocr] [1942].pdf![Neumann, Franz. - Behemoth [ocr] [1942].pdf](https://cdn.slidesharecdn.com/ss_thumbnails/neumannfranz-250302005344-b8decbc6-thumbnail.jpg?width=560&fit=bounds)
Neumann, Franz. - Behemoth [ocr] [1942].pdfFrancisco Sandoval Mart鱈nez
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Fascism, National-Socialism, History(Journal Club) Focused ultrasound excites neurons via mechanosensitive calciu...
(Journal Club) Focused ultrasound excites neurons via mechanosensitive calciu...David Podorefsky, PhD
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(Journal Club) - Sci-fate Characterizes the Dynamics of Gene Expression in Si...
(Journal Club) - Sci-fate Characterizes the Dynamics of Gene Expression in Si...David Podorefsky, PhD
油
(Journal Club) - RNA m6A regulates transcription via DNA demethylation and ch...
(Journal Club) - RNA m6A regulates transcription via DNA demethylation and ch...David Podorefsky, PhD
油
(Journal Club) - Hydro-Seq enables contamination-free high throughput single-...
(Journal Club) - Hydro-Seq enables contamination-free high throughput single-...David Podorefsky, PhD
油
Guide to Pharmacology in 2018 - Flash Presentation
- 1. Dr. Simon D. Harding, University of Edinburgh Poster P252 www.guidetoimmunopharmacology.org A knowledge-base that connects immunology with pharmacology Targets and ligands linked to immunological processes, cell type and disease IUPHAR/BPS Guide to Pharmacology www.guidetopharmacology.org Open, expert-driven database of pharmacological targets and the substances that act on them: ~1,700 drug targets, ~9,400 ligands, including ~1,300 approved drugs New pharmacology search tool & ligand affinity species comparison display IUPHAR/MMV Guide to Malaria Pharmacology Aim to curate antimalarial compounds and Plasmodium molecular targets for approved drugs