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Heamatinics PPT

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sravya pujitha

This document discusses three hematinic vitamins - iron, vitamin B12, and folic acid. It provides details on how iron is absorbed and distributed in the body, factors that can impede absorption, and effects of deficiency. For vitamin B12, it outlines that it is intricately linked to folate metabolism and involved in various metabolic processes. It notes manifestations of deficiency for both vitamins B12 and folic acid. Finally, it discusses uses of vitamins B12 and folic acid, particularly for megaloblastic anemia.

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RAGHAVENDRA INSTITUTE OF PHARMACEUTICAL EDUCATION & RESEARCH HAEMATINICS GUIDED BY: SUDHEER SIR PRESENTED BY: K.SRAVYA PUJITHA.
HAEMATINICS
Heamatinics PPT
Heamatinics PPT
Heamatinics PPT
Heamatinics PPT
Iron Iron is absorbed all over the intestine. Absorbed Directly At luminal membrane- divalent metal transporter1(DMT1) Basolateral membrane ferroportin (FP) Iron is distributed as haemoglobin in erythrocytes Stored as ferritin and haemosiderin in liver spleen bone marrow as myoglobin in muscles as parenchymal iron in reticuloendothelial cells as transferrin which are iron -binding blood plasma glycoprotein
Factors impeding iron absorption Antacids Egg Phytates (in maize and wheat) Tetracyclines Presence of other foods in the stomach Mucosal block (ferritin curtain) the gut has a mechanism of preventing entry of excess iron in the body
Heamatinics PPT
Effects of deficiency Megaloblastic anaemia Spina bifida of the foetus in case of pregnant women Adverse effects: Allergy Anaphylaxis
Heamatinics PPT
Vitamin B12 : Cyanocobalamin and hydrocobalamine referred to as vit B12 Vit B12 is intricately linked to folate metabolism Involved in protein synthesis Involved in DNA production Involved carbohydrate and lipid metabolism Is utilised in thymidylate synthesis
Vitamin B12 required for the the conversion of homocysteine to methionine conversion of methylmalonyl-CoA to succinyl CoA interconversion of leucine and beta leucine Manifestations of deficiency : Megaloblastic anaemia Epithelial damage Neural tube defect General weakness
Heamatinics PPT
Heamatinics PPT
Folic Acid Source: liver, cereals, nuts, green vegetables Pharmacokinetics: Administered through oral or parenteral routes. Absorbed from the proximal jejunum. Widely distributed and stored in the liver Function of Folic acid It is the parent compound of folates folates act as a cofactor in the formation of purine and pyrimidine which is essential for DNA synthesis. Folate cofactor is also needed in the formation of thymidylic acid.
Uses of vitamin B12 and folic acid Megaloblastic anaemia: Nutrtional folate deficiency Increased demand-pregnancy, lactation, infancy, severe iron deficiency Pernicious anaemia (folate deficiency) Malabsorption syndrome- tropical sprue coeliac disease, Antiepileptic therapy causes megaloblastic anaemia Prophylaxis of folate deficiency Methotrexate toxicity are countered
Heamatinics PPT
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Heamatinics PPT

  • 1. RAGHAVENDRA INSTITUTE OF PHARMACEUTICAL EDUCATION & RESEARCH HAEMATINICS GUIDED BY: SUDHEER SIR PRESENTED BY: K.SRAVYA PUJITHA.
  • 7. Iron Iron is absorbed all over the intestine. Absorbed Directly At luminal membrane- divalent metal transporter1(DMT1) Basolateral membrane ferroportin (FP) Iron is distributed as haemoglobin in erythrocytes Stored as ferritin and haemosiderin in liver spleen bone marrow as myoglobin in muscles as parenchymal iron in reticuloendothelial cells as transferrin which are iron -binding blood plasma glycoprotein
  • 8. Factors impeding iron absorption Antacids Egg Phytates (in maize and wheat) Tetracyclines Presence of other foods in the stomach Mucosal block (ferritin curtain) the gut has a mechanism of preventing entry of excess iron in the body
  • 10. Effects of deficiency Megaloblastic anaemia Spina bifida of the foetus in case of pregnant women Adverse effects: Allergy Anaphylaxis
  • 12. Vitamin B12 : Cyanocobalamin and hydrocobalamine referred to as vit B12 Vit B12 is intricately linked to folate metabolism Involved in protein synthesis Involved in DNA production Involved carbohydrate and lipid metabolism Is utilised in thymidylate synthesis
  • 13. Vitamin B12 required for the the conversion of homocysteine to methionine conversion of methylmalonyl-CoA to succinyl CoA interconversion of leucine and beta leucine Manifestations of deficiency : Megaloblastic anaemia Epithelial damage Neural tube defect General weakness
  • 16. Folic Acid Source: liver, cereals, nuts, green vegetables Pharmacokinetics: Administered through oral or parenteral routes. Absorbed from the proximal jejunum. Widely distributed and stored in the liver Function of Folic acid It is the parent compound of folates folates act as a cofactor in the formation of purine and pyrimidine which is essential for DNA synthesis. Folate cofactor is also needed in the formation of thymidylic acid.
  • 17. Uses of vitamin B12 and folic acid Megaloblastic anaemia: Nutrtional folate deficiency Increased demand-pregnancy, lactation, infancy, severe iron deficiency Pernicious anaemia (folate deficiency) Malabsorption syndrome- tropical sprue coeliac disease, Antiepileptic therapy causes megaloblastic anaemia Prophylaxis of folate deficiency Methotrexate toxicity are countered