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RECTAL CA - VAKALIS . X
RECTAL CA - VAKALIS . Xfondas vakalis
油
Rectal cancer treatment typically involves surgery. Local recurrence after conventional surgery occurs in 15-65% of cases on average. Long course preoperative chemoradiotherapy has been shown to reduce local recurrence rates compared to short course preoperative radiotherapy or radiotherapy alone. It increases local tumor control and survival rates with some toxicities but does not reduce colostomy rates. Preoperative chemoradiotherapy is superior to postoperative chemoradiotherapy in reducing local recurrence rates without affecting overall survival.2012-michael joiner-hypofractionation
2012-michael joiner-hypofractionationfondas vakalis
油
The document discusses how tumor radiobiology may impact the move toward hypofractionation in radiation therapy. It reviews evidence that the classic linear-quadratic model does not fully capture tumor response at high radiation doses, and that other factors like vascular damage and immune effects become more important. Response heterogeneity between different tumor cell populations may also help explain why survival curves appear more linear at higher doses per fraction.
Vakalis breast radiotherapy
Vakalis breast radiotherapyfondas vakalis
油
The document discusses breast cancer treatment recommendations including:
- No radiation therapy is recommended for early stage DCIS or invasive breast cancer.
- A tumor bed boost is recommended for higher risk patients but large trials found no survival difference with or without a boost.
- Hypofractionated whole breast radiation has become a standard option based on trials showing no difference in survival outcomes compared to conventional fractionation.
- Several trials investigated omitting axillary lymph node dissection or radiation with favorable results for select patient groups with low tumor burden.radiotherapy-pancreatic cancer
radiotherapy-pancreatic cancerfondas vakalis
油
This document discusses pancreatic cancer and its treatment. It begins by stating that pancreatic cancer is most commonly diagnosed as locally advanced or metastatic. It then discusses the role of surgery, chemotherapy, and radiation therapy in the treatment of pancreatic cancer. It notes that the majority of surgically treated patients will have a recurrence, with a median survival of 15-20 months. The value of adjuvant and neoadjuvant therapy is debated. The document summarizes several clinical trials investigating chemotherapy and chemoradiation as adjuvant treatment after surgery. It also discusses neoadjuvant therapy and its potential advantages over adjuvant therapy. Emerging strategies discussed include induction chemotherapy followed by localized chemoradiation or second line therapy. The document concludes by describing modern radiation
Rectum & anal canal
Rectum & anal canalMehul Tandel
油
This document summarizes key anatomical features of the rectum and anal canal. It describes the rectum's length, curvature, blood supply, nerve supply and relations to surrounding structures. It discusses the anal canal's measurements and divisions. It also outlines the musculature including the internal and external anal sphincters. Clinical conditions involving the rectum and anal canal like hemorrhoids, anal fissures and fistulas are briefly mentioned.
5 points on twitter with frank brunke
5 points on twitter with frank brunkeFrank Brunke
油
This document provides an overview of Twitter and how it can be used. It discusses that Twitter is a private company founded in 2006 that currently has over 500 million users. It describes common Twitter features like @mentions, hashtags, retweets, and lists. It also notes that while the number of followers is not as important as influence, users should be cautious about following strangers or clicking unknown links due to security risks. Finally, it suggests ways Twitter can be used for self-promotion, getting user feedback, asking questions, participating in real-time discussions, and serving as a second screen experience.
one woman satisfies 12 men
one woman satisfies 12 menfondas vakalis
油
The document discusses how a woman could satisfy 12 men at once but warns the content may not be suitable for all readers and requires an open mind. It claims to contain a revealing photo related to the topic but provides no other useful information.Rockets
RocketsHarvey Utech
油
際際滷s designed to accompany "How Rockets Work" reading, available elsewhere on 際際滷Share.SQL212.3 Introduction to SQL using Oracle Module 3
SQL212.3 Introduction to SQL using Oracle Module 3Dan D'Urso
油
The document is a module on SQL programming that covers:
1) Modifying data through insert, update, and delete statements.
2) Managing database structures like tables, views, and indexes.
3) Security concepts like granting and revoking user privileges.
4) Each section provides examples and explanations of SQL statements.SQL206 SQL Median
SQL206 SQL MedianDan D'Urso
油
The document discusses calculating the median value of a dataset in SQL. It explains that the median is the middle value when values are sorted from lowest to highest. The document provides SQL code to calculate the median by selecting the top and bottom 50% of values, taking the maximum of the top and minimum of the bottom, and averaging those values. It uses the "Parts" table as an example dataset and walks through creating the table, loading sample data, and executing the median calculation query.4005-713 ` XML Architecture, Tools & Technique ` Presentation
4005-713 ` XML Architecture, Tools & Technique ` Presentationlitcigar
油
AJAX allows for asynchronous updating of parts of a web page in the background without reloading the entire page. It uses a combination of technologies including JavaScript, XML, HTML, and CSS to retrieve data from the server and update portions of the web page. This creates a more interactive and responsive experience for the user by reducing page reloads. Some key advantages are that it improves responsiveness, reduces bandwidth usage, and decreases server requests by only updating parts of the page. However, it also has some disadvantages like browser incompatibility issues and difficulties with bookmarking and search engine indexing.How Electricity Works
How Electricity WorksHarvey Utech
油
The document provides an overview of how electricity works. It explains that electricity is the flow of electrons through conductors. Materials like metals have free electrons that allow electricity to flow, while insulators do not. Generators use magnets to induce electron flow, creating electricity. Electrical circuits require a power source, conductor, and load to provide a complete path for electrons to flow through. The voltage pushes electrons through the circuit, while current is the flow of electrons and resistance impedes their flow. Alternating current produced by power plants flows back and forth rather than one direction.Nice Travel
Nice Travelfondas vakalis
油
The document lists the names of various geographic locations around the world in no particular order. Some of the locations mentioned include the Yamuna River in Agra, India, the White House Ruin in Canyon de Chelly National Monument in Arizona, and terraced rice paddies in Ubud Area, Bali, Indonesia. A wide range of places from North America, Asia, Africa, Europe, and Antarctica are referenced.Volcano Powerpt
Volcano Powerptkopchick4141
油
Volcanoes are openings in the Earth's crust where magma and other material erupt from below the surface. There are three main types of volcanoes - shield volcanoes which have broad, gentle slopes; cinder cones which are small and steep sided; and composite or strato-volcanoes which are built up of layers of lava and ash. The type of magma influences the shape of the volcano - basaltic magma forms shield volcanoes, andesitic can form either composite or gentle volcanoes, and rhyolitic magma fuels very explosive eruptions. When magma reaches the surface it is called lava, and eruptions can eject ash, bombs, cinders, pum
Robots
RobotsHarvey Utech
油
These slides provide an overview of robots and are licensed under Creative Commons, allowing sharing and adaptation with attribution. The slides cover how various robots work from industrial robots to mobile robots to homebrew robots. Artificial intelligence is also discussed in the context of robots at movies. The slides are meant to accompany a reading on how robots work and the creator welcomes improvements to be shared.ifilms Company Profile
ifilms Company ProfileTarek Fahim
油
iFilms Media is a regional media production company based in Cairo. With a team of innovative filmmakers and creative entrepreneurs, iFilms focuses on creating products that are entertaining, informative and unique. Our products have been broadcasted on both local and satellite channels across the Arab region. With 5 years of market experience, iFilms ensures its clients the best talent the market has to offer. We offer our services through five main segments of Media Production; Documentary Films, TV Shows, Fillers, News Reports, Motion Graphics and Advertisementsradiotherapy of bone metastases,Vakalis
radiotherapy of bone metastases,Vakalisfondas vakalis
油
This document provides information on the evaluation and treatment of metastatic bone disease and spinal cord compression. It discusses:
1. Common sites of bone metastases from various primary cancers. Imaging tools to evaluate bone metastases like x-rays, bone scans, CT, PET, and MRI scans are described.
2. A multi-disciplinary treatment approach is recommended, including medical treatment, surgery, radiotherapy, radionuclides, chemotherapy, and hormonal therapy.
3. Details are provided on conventional and advanced radiation therapy techniques for treating bone metastases and spinal cord compression, including stereotactic radiosurgery. Overall pain relief rates, time to pain relief, and the benefits of combining surgery and radiation therapy aresbrt for inoperable lung cancer
sbrt for inoperable lung cancerfondas vakalis
油
This document discusses stereotactic body radiotherapy (SBRT) for early stage lung cancer patients who cannot undergo surgery. It describes how SBRT delivers a high radiation dose to the tumor in just 1-5 sessions. Studies show SBRT provides improved tumor control compared to conventional radiotherapy, with surprisingly low toxicity. Early investigations found 3-year tumor control rates of 60-80% with SBRT, similar to surgery. Larger prospective trials of SBRT for medically inoperable early stage lung cancer patients demonstrated 3-year local control of 90-98% and low risks of side effects. SBRT provides an effective non-invasive alternative to surgery for these high-risk patients.Spinal cord compression bhf aos study day mar 2014 final
Spinal cord compression bhf aos study day mar 2014 finalfondas vakalis
油
This document provides an overview of malignant spinal cord compression (MSCC). It begins with a clinical case of a 56-year-old man initially diagnosed with back pain who is later found to have prostate cancer with MSCC. The talk then covers the anatomy of the spinal cord, definition and incidence of MSCC, typical symptoms, investigations including MRI, and treatment options like surgery, radiotherapy, and steroids. Outcomes are discussed, with the median survival being 6 months. The document concludes by outlining the key priorities for implementing NICE guidance on MSCC, including early detection and treatment of suspected cases as emergencies.Vakalis - RT for prostate cancer
Vakalis - RT for prostate cancerfondas vakalis
油
This document discusses recent data on radiation therapy for prostate cancer. It begins by outlining the risk of prostate cancer development and mortality rates over time. It then examines risk stratification systems and treatment options for low, intermediate, and high risk disease. The document focuses on the benefits of dose escalation in radiation therapy, noting several studies that found higher radiation doses improved outcomes with acceptable toxicity when using newer techniques like IMRT. It also discusses hypofractionated regimens and image-guided radiation as ways to further improve the therapeutic ratio. In summary, this document reviews evidence that higher and more precisely delivered radiation doses can improve prostate cancer control while maintaining reasonable side effects.
Second line therapy for nsclc
Second line therapy for nsclcfondas vakalis
油
This document summarizes a presentation on new perspectives on second-line therapy for non-small cell lung cancer (NSCLC). The presentation discusses current standards of care for second-line NSCLC, the unique needs of patients without targetable mutations, and emerging research findings. One study presented was the LUME-Lung 1 trial which found that the addition of the angiogenesis inhibitor nintedanib to docetaxel improved progression-free survival compared to placebo plus docetaxel in second-line NSCLC, with a significant overall survival benefit seen in the adenocarcinoma subgroup. Outstanding issues regarding biomarkers and the role of nintedanib in squamous cell carcinoma were discussed.
Radiobiology behind dose fractionation
Radiobiology behind dose fractionationfondas vakalis
油
The document discusses the radiobiology behind dose fractionation in radiation therapy. It provides an overview of the linear quadratic model which describes how cell survival changes with dose and is used to determine biologically equivalent doses for different fractionation schedules. The model assumes equal effect per fraction but may not be accurate at high or low doses. Fractionation takes advantage of the four R's - repair, repopulation, redistribution, and reoxygenation - to better kill tumors while sparing normal tissues. The alpha/beta ratio indicates a tissue's sensitivity to fractionation and is used to estimate equivalent total doses for different fraction sizes.More Related Content
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5 points on twitter with frank brunke
5 points on twitter with frank brunkeFrank Brunke
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This document provides an overview of Twitter and how it can be used. It discusses that Twitter is a private company founded in 2006 that currently has over 500 million users. It describes common Twitter features like @mentions, hashtags, retweets, and lists. It also notes that while the number of followers is not as important as influence, users should be cautious about following strangers or clicking unknown links due to security risks. Finally, it suggests ways Twitter can be used for self-promotion, getting user feedback, asking questions, participating in real-time discussions, and serving as a second screen experience.one woman satisfies 12 men
one woman satisfies 12 menfondas vakalis
油
The document discusses how a woman could satisfy 12 men at once but warns the content may not be suitable for all readers and requires an open mind. It claims to contain a revealing photo related to the topic but provides no other useful information.Rockets
RocketsHarvey Utech
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際際滷s designed to accompany "How Rockets Work" reading, available elsewhere on 際際滷Share.SQL212.3 Introduction to SQL using Oracle Module 3
SQL212.3 Introduction to SQL using Oracle Module 3Dan D'Urso
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The document is a module on SQL programming that covers:
1) Modifying data through insert, update, and delete statements.
2) Managing database structures like tables, views, and indexes.
3) Security concepts like granting and revoking user privileges.
4) Each section provides examples and explanations of SQL statements.SQL206 SQL Median
SQL206 SQL MedianDan D'Urso
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The document discusses calculating the median value of a dataset in SQL. It explains that the median is the middle value when values are sorted from lowest to highest. The document provides SQL code to calculate the median by selecting the top and bottom 50% of values, taking the maximum of the top and minimum of the bottom, and averaging those values. It uses the "Parts" table as an example dataset and walks through creating the table, loading sample data, and executing the median calculation query.4005-713 ` XML Architecture, Tools & Technique ` Presentation
4005-713 ` XML Architecture, Tools & Technique ` Presentationlitcigar
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AJAX allows for asynchronous updating of parts of a web page in the background without reloading the entire page. It uses a combination of technologies including JavaScript, XML, HTML, and CSS to retrieve data from the server and update portions of the web page. This creates a more interactive and responsive experience for the user by reducing page reloads. Some key advantages are that it improves responsiveness, reduces bandwidth usage, and decreases server requests by only updating parts of the page. However, it also has some disadvantages like browser incompatibility issues and difficulties with bookmarking and search engine indexing.How Electricity Works
How Electricity WorksHarvey Utech
油
The document provides an overview of how electricity works. It explains that electricity is the flow of electrons through conductors. Materials like metals have free electrons that allow electricity to flow, while insulators do not. Generators use magnets to induce electron flow, creating electricity. Electrical circuits require a power source, conductor, and load to provide a complete path for electrons to flow through. The voltage pushes electrons through the circuit, while current is the flow of electrons and resistance impedes their flow. Alternating current produced by power plants flows back and forth rather than one direction.Nice Travel
Nice Travelfondas vakalis
油
The document lists the names of various geographic locations around the world in no particular order. Some of the locations mentioned include the Yamuna River in Agra, India, the White House Ruin in Canyon de Chelly National Monument in Arizona, and terraced rice paddies in Ubud Area, Bali, Indonesia. A wide range of places from North America, Asia, Africa, Europe, and Antarctica are referenced.Volcano Powerpt
Volcano Powerptkopchick4141
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Volcanoes are openings in the Earth's crust where magma and other material erupt from below the surface. There are three main types of volcanoes - shield volcanoes which have broad, gentle slopes; cinder cones which are small and steep sided; and composite or strato-volcanoes which are built up of layers of lava and ash. The type of magma influences the shape of the volcano - basaltic magma forms shield volcanoes, andesitic can form either composite or gentle volcanoes, and rhyolitic magma fuels very explosive eruptions. When magma reaches the surface it is called lava, and eruptions can eject ash, bombs, cinders, pumRobots
RobotsHarvey Utech
油
These slides provide an overview of robots and are licensed under Creative Commons, allowing sharing and adaptation with attribution. The slides cover how various robots work from industrial robots to mobile robots to homebrew robots. Artificial intelligence is also discussed in the context of robots at movies. The slides are meant to accompany a reading on how robots work and the creator welcomes improvements to be shared.ifilms Company Profile
ifilms Company ProfileTarek Fahim
油
iFilms Media is a regional media production company based in Cairo. With a team of innovative filmmakers and creative entrepreneurs, iFilms focuses on creating products that are entertaining, informative and unique. Our products have been broadcasted on both local and satellite channels across the Arab region. With 5 years of market experience, iFilms ensures its clients the best talent the market has to offer. We offer our services through five main segments of Media Production; Documentary Films, TV Shows, Fillers, News Reports, Motion Graphics and AdvertisementsMore from fondas vakalis (20)
radiotherapy of bone metastases,Vakalis
radiotherapy of bone metastases,Vakalisfondas vakalis
油
This document provides information on the evaluation and treatment of metastatic bone disease and spinal cord compression. It discusses:
1. Common sites of bone metastases from various primary cancers. Imaging tools to evaluate bone metastases like x-rays, bone scans, CT, PET, and MRI scans are described.
2. A multi-disciplinary treatment approach is recommended, including medical treatment, surgery, radiotherapy, radionuclides, chemotherapy, and hormonal therapy.
3. Details are provided on conventional and advanced radiation therapy techniques for treating bone metastases and spinal cord compression, including stereotactic radiosurgery. Overall pain relief rates, time to pain relief, and the benefits of combining surgery and radiation therapy aresbrt for inoperable lung cancer
sbrt for inoperable lung cancerfondas vakalis
油
This document discusses stereotactic body radiotherapy (SBRT) for early stage lung cancer patients who cannot undergo surgery. It describes how SBRT delivers a high radiation dose to the tumor in just 1-5 sessions. Studies show SBRT provides improved tumor control compared to conventional radiotherapy, with surprisingly low toxicity. Early investigations found 3-year tumor control rates of 60-80% with SBRT, similar to surgery. Larger prospective trials of SBRT for medically inoperable early stage lung cancer patients demonstrated 3-year local control of 90-98% and low risks of side effects. SBRT provides an effective non-invasive alternative to surgery for these high-risk patients.Spinal cord compression bhf aos study day mar 2014 final
Spinal cord compression bhf aos study day mar 2014 finalfondas vakalis
油
This document provides an overview of malignant spinal cord compression (MSCC). It begins with a clinical case of a 56-year-old man initially diagnosed with back pain who is later found to have prostate cancer with MSCC. The talk then covers the anatomy of the spinal cord, definition and incidence of MSCC, typical symptoms, investigations including MRI, and treatment options like surgery, radiotherapy, and steroids. Outcomes are discussed, with the median survival being 6 months. The document concludes by outlining the key priorities for implementing NICE guidance on MSCC, including early detection and treatment of suspected cases as emergencies.Vakalis - RT for prostate cancer
Vakalis - RT for prostate cancerfondas vakalis
油
This document discusses recent data on radiation therapy for prostate cancer. It begins by outlining the risk of prostate cancer development and mortality rates over time. It then examines risk stratification systems and treatment options for low, intermediate, and high risk disease. The document focuses on the benefits of dose escalation in radiation therapy, noting several studies that found higher radiation doses improved outcomes with acceptable toxicity when using newer techniques like IMRT. It also discusses hypofractionated regimens and image-guided radiation as ways to further improve the therapeutic ratio. In summary, this document reviews evidence that higher and more precisely delivered radiation doses can improve prostate cancer control while maintaining reasonable side effects.Second line therapy for nsclc
Second line therapy for nsclcfondas vakalis
油
This document summarizes a presentation on new perspectives on second-line therapy for non-small cell lung cancer (NSCLC). The presentation discusses current standards of care for second-line NSCLC, the unique needs of patients without targetable mutations, and emerging research findings. One study presented was the LUME-Lung 1 trial which found that the addition of the angiogenesis inhibitor nintedanib to docetaxel improved progression-free survival compared to placebo plus docetaxel in second-line NSCLC, with a significant overall survival benefit seen in the adenocarcinoma subgroup. Outstanding issues regarding biomarkers and the role of nintedanib in squamous cell carcinoma were discussed.Radiobiology behind dose fractionation
Radiobiology behind dose fractionationfondas vakalis
油
The document discusses the radiobiology behind dose fractionation in radiation therapy. It provides an overview of the linear quadratic model which describes how cell survival changes with dose and is used to determine biologically equivalent doses for different fractionation schedules. The model assumes equal effect per fraction but may not be accurate at high or low doses. Fractionation takes advantage of the four R's - repair, repopulation, redistribution, and reoxygenation - to better kill tumors while sparing normal tissues. The alpha/beta ratio indicates a tissue's sensitivity to fractionation and is used to estimate equivalent total doses for different fraction sizes.
Vakalis new techniques in breast radiotherapy
Vakalis new techniques in breast radiotherapyfondas vakalis
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This document discusses therapeutic approaches to breast cancer treatment, focusing on radiotherapy techniques. It provides a historical overview of radiotherapy and highlights results from randomized trials demonstrating the benefits of radiotherapy after lumpectomy in reducing local recurrence rates and improving survival. Modern external beam radiotherapy techniques like 3D conformal radiation therapy and accelerated partial breast irradiation are described. Various techniques for partial breast irradiation including brachytherapy, MammoSite, and 3D-CRT are summarized along with their benefits, limitations, and results from studies. Ongoing trials evaluating partial breast irradiation are also mentioned.
New techniques in breast radiotherapy
New techniques in breast radiotherapyfondas vakalis
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This document discusses new techniques in breast radiotherapy, including partial breast irradiation (PBI). It describes several techniques for PBI including interstitial brachytherapy using catheters, intracavitary brachytherapy using the Mammosite device, and 3D conformal external beam radiation therapy. The document highlights the potential benefits of PBI such as reduced treatment time from 6 weeks to 1 week, decreased toxicity, and increased utilization of breast conserving therapy. However, it also notes limitations including the need for additional surgery with some techniques and the lack of long-term data comparing PBI to standard whole breast irradiation.
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The document discusses standards for precision in radiation oncology, including definitions of target volumes and dose reporting levels according to International Commission on Radiation Units and Measurements (ICRU) reports. It notes unresolved issues for 3D conformal radiation therapy and intensity-modulated radiation therapy, such as margins between gross tumor and clinical target volumes. The document recommends that a new ICRU report is needed to address these modern radiotherapy techniques and provide common guidelines.Neurotoxicity
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Neurotoxicity, commonly caused by cytotoxic cancer therapy, can damage the central or peripheral nervous system. Ifosfamide chemotherapy can cause central neurotoxicity like encephalopathy or myelopathy. It is metabolized into neurotoxic compounds that damage mitochondria. Methylene blue may help restore mitochondrial function and prevent or treat ifosfamide neurotoxicity. Chemotherapy-induced peripheral neuropathy is a common side effect of neurotoxic drugs like platinum analogs, taxanes, and vinca alkaloids. It involves damage to dorsal root ganglia and axons, disrupting transport and causing length-dependent nerve damage. Symptoms include numbness, tingling and pain in hands and feet. Risk factors includeRecently uploaded (20)
Acute & Chronic Inflammation, Chemical mediators in Inflammation and Wound he...
Acute & Chronic Inflammation, Chemical mediators in Inflammation and Wound he...Ganapathi Vankudoth
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A complete information of Inflammation, it includes types of Inflammation, purpose of Inflammation, pathogenesis of acute inflammation, chemical mediators in inflammation, types of chronic inflammation, wound healing and Inflammation in skin repair, phases of wound healing, factors influencing wound healing and types of wound healing.One Health Rabies Control in Indonesia_APCAT meeting May 2022.pptx
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This presentation delves into the latest advancements in non-invasive intracranial pressure (ICP) monitoring techniques, specifically tailored for neurosurgeons. It covers the importance of ICP monitoring in clinical practice, explores various non-invasive methods, and discusses their accuracy, reliability, and clinical applications. Attendees will gain insights into the benefits of non-invasive approaches over traditional invasive methods, including reduced risk of complications and improved patient outcomes. This comprehensive overview is designed to enhance the knowledge and skills of neurosurgeons in managing patients with neurological conditions.
Invasive systems are commonly used for monitoring intracranial pressure (ICP) in traumatic brain injury (TBI) and are considered the gold standard. The availability of invasive ICP monitoring is heterogeneous, and in low- and middle-income settings, these systems are not routinely employed due to high cost or limited accessibility. The aim of this presentation is to develop recommendations to guide monitoring and ICP-driven therapies in TBI using non-invasive ICP (nICP) systems.
legal Rights of individual, children and women.pptx
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