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By
Kevin KF Ng, MD, PhD.
Former Associate Professor of Medicine
Division of Clinical Pharmacology
University of Miami, Miami, FL., USA
Email: kevinng68@gmail.com
A 際際滷 Presentation for HealthCare Providers March 2023
Contents
 Poll results in LinkedIn Post.
 What is chicken soup?
 History of chicken soup.
 Nutrients of chicken soup.
 Ingredients in chicken soup.
 Scientific studies.
 Mechanisms of action.
 Summary.
Poll results on Is chicken soup a good symptom reliever for a common cold? posted
in LinkedIn from 2/15/2023 to 2/23/2023
https://www.linkedin.com/analytics/post-summary/urn:li:activity:7031501858342924289/
https://www.linkedin.com/analytics/post-
summary/urn:li:activity:7031501858342924289/
Poll results on Is chicken soup a good symptom reliever for a common cold? posted
in LinkedIn from 2/15/2023 to 2/23/2023
History of chicken soup
Sources: Internet
What is in a chicken soup?
 Chicken soup is a mixture of chicken meat cooked with
vegetables, fruits, herbs and spices. Noodles and rice
may be added.
 A typical Chinese chicken soup is made with
 chicken meat
 onions
 garlics
 ginger
 salt
 noodles.
 The ingredients vary widely from countries to countries.
Chicken soups around the world in 6 continents








 


 





















 














1. Asia
2. Africa
3. Australasia
4. Europe
5. North America
6. South America.
Sources: Internet
Number of publications on chicken soup in PubMed from
1970 to 2022
https://pubmed.ncbi.nlm.nih.gov/?term=chicken+soup
NUTRIENT COMPOSITION
Composition of Chicken Soup
息DRKEVINNG
Major chemicals in Chinese Chicken Soup
:cysteine
息DRKEVINNG
Major bioactive compounds and their properties
in Chinese chicken soup
息DRKEVINNG
Ingredient variations in chicken soup
across the world
息DRKEVINNG
BIOACTIVE COMPOUNDS
 CYSTEINE
 PHYTOCHEMICALS
What is cysteine in chicken soup?
 Cysteine is a nonessential amino acid important for making proteins.
 Cysteine is present in the chicken meat
 Cysteine is a precursor to glutathione (a three-peptide antioxidant in all cells)
glutathione
Ginger enhanced the release of cysteine in
Chicken Soup (2021)
Adapted from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307344/
n.d.
n.d.=not detected
Reported pharmacological activities of cysteine
 Antibacterial
 Antioxidant
 Anti-inflammatory
 Immuno-modulatory
 Anticancer
 Mucolytic
 Precursor to glutathione
https://link.springer.com/article/10.1007/s00726-021-03062-z
Anti-inflammatory effect of cysteine on nuclear factor-kappa B
(NF-虜B) activation (2012)
Clin Exp Immunol. 2012 Feb; 167(2): 269274.
Nuclear factor kappa B (NF-虜B) is a protein transcription factor and
considered a regulator of innate immunity.
Metabilism of cysteine on passage through the liver
息DRKEVINNG
Fate of cysteine in the human body
 Cysteineis utilized by multiple pathways. Once generated,cysteine is consumed by variousmetabolic pathwayssuch as
protein synthesis, generationof glutathione,taurine, lanthionine,coenzyme A and the gasotransmitter hydrogen sulfide
(H2S).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912966/#:~:text=Metabolism%20
of%20cysteine&text=(B)%20Cysteine%20is%20utilized%20by,sulfide%20(H2S).
PHYTOCHEMICALS IN CHICKEN SOUP INGREDIENTS
Major Bioactive compounds in an onion (Allium cepa)
Adapted from https://www.sciencedirect.com/topics/medicine-and-dentistry/s-allyl-cysteine
N-acetylcysteine (NAC)
4.5 mg/100g*
*https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136759/
Major bioactive compounds in garlic (Allium sativum)
https://lpi.oregonstate.edu/book/export/html/394
a precursor to glutathione (GSH),
Bioactive compounds in ginger (zingiber officinale)
https://www.precisionnutrition.com/all-about-ginger
30%
Pharmacological properties of chicken soup ingredients
(NAC)
息DRKEVINNG
SCIENTIFIC STUDIES
 NASALMUCUS PRODUCTION
 NEUTROPHIL CHEMOTAXIS
 IMMUNO-MODULATION
How chicken soup relieves common cold symptoms
Chicken soup increased nasal mucus secretion in
15 healthy subjects (1978)
https://www.sciencedirect.com/science/article/abs/pii/S0012369215373876
https://journal.chestnet.org/article/S0012-3692%2815%2937721-7/pdf
Grandmas Chicken Soup recipe used in the following study:
Chicken soup inhibits neutrophil chemotaxis in vitro (2000)
https://www.unmc.edu/news/stories/chicken-soup.html https://hal.science/hal-03427686/document
Cell viability and inhibition of chemotaxis by
chicken soup ingredients (2000)
https://journal.chestnet.org/article/S0012-3692%2815%2937721-7/pdf
 
vegetables
% Cell viability Chemotaxis (Cells/PHF)
How chicken soup relieves common cold symptoms
Effects of chicken soups on the serum cytokines in the
immunosuppressed mice. (2022)
Abbreviations:
 CBS, Cobb broiler soup;
 GCS, Gushi chicken soup;
 HCS, Honglashan chicken soup;
 MC, model control;
 NC, normal control.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411684/
Effects of chicken soups on the release of immunoglobulins in
the immunosuppressed mice (2022)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411684/
Normal control (NC), Model control (MC), Gushi Chicken Soup (GCS), Honglashan Chicken Soup (HCS), and Cobb Broiler Soup (CBS)
COMMON COLD
 INCIDENCE
 SYMPTOMS
TREATMENT
Common Cold Virus
Mean annual incidence of respiratory illnesses
per person by age group (2003)
https://www.thelancet.com/journals/lancet/article/PIIS0140673603121629/fulltext
Symptoms of a common cold
 The symptoms of a common cold vary from person to person. They can include:
 A runny nose
 A sore throat
 Sneezing
 Coughing
 Watery eyes
 A headache
https://www.pinterest.com/pin/675258537867740315/
Difference between a cold and a flu (influenza)
Common cold
 Runny nose
 A sore throat
 Sneezing
 Coughing
 Watery eyes
 A headache
Influenza (Flu)
 A cough full of mucus.
 A sore throat can be the
first sign of a flu.
 A blocked nose
 Headaches. They nearly
always come with the flu.
 A fever above 102o
.
 Body aches and pains.
息DRKEVINNG
Treatment for the common cold
 There is no cure for the common cold caused by rhinovirus
 There is no vaccine for the prevention of common cold.
 There is no antiviral drug that targets rhinovirus.
 Fortunately, the illness is self-limiting.
 The symptoms of the common cold are usually relieved by chicken soup.
Over-the-counter medications are generally ineffective
息DRKEVINNG
The question is:
Why is chicken soup commonly used as a home remedy?
息DRKEVINNG
Ineffective
Widely used
Answer:
Synergy of cysteine and phytochemicals in the chicken soup
 Chicken meat:
 cysteine
 Precursor of glutathione
 mucolytic
 Antioxidant
 Anti-inflammatory
 Immuno-modulatory
 Ingredients from vegetable and spice:
 Onion phytochemicals
 Garlic phytochemicals
 Ginger phytochemicals
How does chicken soup relieve the common cold symptoms?
息DRKEVINNG
Effect of chicken soup
Chicken soup reduced severity and duration of cold symptoms
息DRKEVINNG
Examples of some delicious chicken soups
Summary
 Chicken soup became popular in China more than two thousand years ago.
 The soup is made by cooking chicken with vegetables or herbs.
 Chicken soup has now spread to almost every country in the world.
 Scientific studies on how chicken soups affect the commoncold are scarce.
 A few studies show that chicken cooked with vegetables, herbs or spices produced
mucolytic, immuno-modulatory and anti-inflammatory effects.
 The pharmacological effects are attributed to cysteine in the chicken meat and
phytochemicals in the ingredients.
How chicken soup relieves common cold symptoms

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How chicken soup relieves common cold symptoms

  • 1. By Kevin KF Ng, MD, PhD. Former Associate Professor of Medicine Division of Clinical Pharmacology University of Miami, Miami, FL., USA Email: kevinng68@gmail.com A 際際滷 Presentation for HealthCare Providers March 2023
  • 2. Contents Poll results in LinkedIn Post. What is chicken soup? History of chicken soup. Nutrients of chicken soup. Ingredients in chicken soup. Scientific studies. Mechanisms of action. Summary.
  • 3. Poll results on Is chicken soup a good symptom reliever for a common cold? posted in LinkedIn from 2/15/2023 to 2/23/2023 https://www.linkedin.com/analytics/post-summary/urn:li:activity:7031501858342924289/
  • 4. https://www.linkedin.com/analytics/post- summary/urn:li:activity:7031501858342924289/ Poll results on Is chicken soup a good symptom reliever for a common cold? posted in LinkedIn from 2/15/2023 to 2/23/2023
  • 5. History of chicken soup Sources: Internet
  • 6. What is in a chicken soup? Chicken soup is a mixture of chicken meat cooked with vegetables, fruits, herbs and spices. Noodles and rice may be added. A typical Chinese chicken soup is made with chicken meat onions garlics ginger salt noodles. The ingredients vary widely from countries to countries.
  • 7. Chicken soups around the world in 6 continents 1. Asia 2. Africa 3. Australasia 4. Europe 5. North America 6. South America. Sources: Internet
  • 8. Number of publications on chicken soup in PubMed from 1970 to 2022 https://pubmed.ncbi.nlm.nih.gov/?term=chicken+soup
  • 10. Composition of Chicken Soup 息DRKEVINNG
  • 11. Major chemicals in Chinese Chicken Soup :cysteine 息DRKEVINNG
  • 12. Major bioactive compounds and their properties in Chinese chicken soup 息DRKEVINNG
  • 13. Ingredient variations in chicken soup across the world 息DRKEVINNG
  • 15. What is cysteine in chicken soup? Cysteine is a nonessential amino acid important for making proteins. Cysteine is present in the chicken meat Cysteine is a precursor to glutathione (a three-peptide antioxidant in all cells) glutathione
  • 16. Ginger enhanced the release of cysteine in Chicken Soup (2021) Adapted from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307344/ n.d. n.d.=not detected
  • 17. Reported pharmacological activities of cysteine Antibacterial Antioxidant Anti-inflammatory Immuno-modulatory Anticancer Mucolytic Precursor to glutathione https://link.springer.com/article/10.1007/s00726-021-03062-z
  • 18. Anti-inflammatory effect of cysteine on nuclear factor-kappa B (NF-虜B) activation (2012) Clin Exp Immunol. 2012 Feb; 167(2): 269274. Nuclear factor kappa B (NF-虜B) is a protein transcription factor and considered a regulator of innate immunity.
  • 19. Metabilism of cysteine on passage through the liver 息DRKEVINNG
  • 20. Fate of cysteine in the human body Cysteineis utilized by multiple pathways. Once generated,cysteine is consumed by variousmetabolic pathwayssuch as protein synthesis, generationof glutathione,taurine, lanthionine,coenzyme A and the gasotransmitter hydrogen sulfide (H2S). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912966/#:~:text=Metabolism%20 of%20cysteine&text=(B)%20Cysteine%20is%20utilized%20by,sulfide%20(H2S).
  • 21. PHYTOCHEMICALS IN CHICKEN SOUP INGREDIENTS
  • 22. Major Bioactive compounds in an onion (Allium cepa) Adapted from https://www.sciencedirect.com/topics/medicine-and-dentistry/s-allyl-cysteine N-acetylcysteine (NAC) 4.5 mg/100g* *https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136759/
  • 23. Major bioactive compounds in garlic (Allium sativum) https://lpi.oregonstate.edu/book/export/html/394 a precursor to glutathione (GSH),
  • 24. Bioactive compounds in ginger (zingiber officinale) https://www.precisionnutrition.com/all-about-ginger 30%
  • 25. Pharmacological properties of chicken soup ingredients (NAC) 息DRKEVINNG
  • 26. SCIENTIFIC STUDIES NASALMUCUS PRODUCTION NEUTROPHIL CHEMOTAXIS IMMUNO-MODULATION
  • 28. Chicken soup increased nasal mucus secretion in 15 healthy subjects (1978) https://www.sciencedirect.com/science/article/abs/pii/S0012369215373876
  • 30. Grandmas Chicken Soup recipe used in the following study: Chicken soup inhibits neutrophil chemotaxis in vitro (2000) https://www.unmc.edu/news/stories/chicken-soup.html https://hal.science/hal-03427686/document
  • 31. Cell viability and inhibition of chemotaxis by chicken soup ingredients (2000) https://journal.chestnet.org/article/S0012-3692%2815%2937721-7/pdf vegetables % Cell viability Chemotaxis (Cells/PHF)
  • 33. Effects of chicken soups on the serum cytokines in the immunosuppressed mice. (2022) Abbreviations: CBS, Cobb broiler soup; GCS, Gushi chicken soup; HCS, Honglashan chicken soup; MC, model control; NC, normal control. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411684/
  • 34. Effects of chicken soups on the release of immunoglobulins in the immunosuppressed mice (2022) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411684/ Normal control (NC), Model control (MC), Gushi Chicken Soup (GCS), Honglashan Chicken Soup (HCS), and Cobb Broiler Soup (CBS)
  • 35. COMMON COLD INCIDENCE SYMPTOMS TREATMENT
  • 37. Mean annual incidence of respiratory illnesses per person by age group (2003) https://www.thelancet.com/journals/lancet/article/PIIS0140673603121629/fulltext
  • 38. Symptoms of a common cold The symptoms of a common cold vary from person to person. They can include: A runny nose A sore throat Sneezing Coughing Watery eyes A headache https://www.pinterest.com/pin/675258537867740315/
  • 39. Difference between a cold and a flu (influenza) Common cold Runny nose A sore throat Sneezing Coughing Watery eyes A headache Influenza (Flu) A cough full of mucus. A sore throat can be the first sign of a flu. A blocked nose Headaches. They nearly always come with the flu. A fever above 102o . Body aches and pains. 息DRKEVINNG
  • 40. Treatment for the common cold There is no cure for the common cold caused by rhinovirus There is no vaccine for the prevention of common cold. There is no antiviral drug that targets rhinovirus. Fortunately, the illness is self-limiting. The symptoms of the common cold are usually relieved by chicken soup.
  • 41. Over-the-counter medications are generally ineffective 息DRKEVINNG
  • 42. The question is: Why is chicken soup commonly used as a home remedy? 息DRKEVINNG Ineffective Widely used
  • 43. Answer: Synergy of cysteine and phytochemicals in the chicken soup Chicken meat: cysteine Precursor of glutathione mucolytic Antioxidant Anti-inflammatory Immuno-modulatory Ingredients from vegetable and spice: Onion phytochemicals Garlic phytochemicals Ginger phytochemicals
  • 44. How does chicken soup relieve the common cold symptoms? 息DRKEVINNG Effect of chicken soup
  • 45. Chicken soup reduced severity and duration of cold symptoms 息DRKEVINNG
  • 46. Examples of some delicious chicken soups
  • 47. Summary Chicken soup became popular in China more than two thousand years ago. The soup is made by cooking chicken with vegetables or herbs. Chicken soup has now spread to almost every country in the world. Scientific studies on how chicken soups affect the commoncold are scarce. A few studies show that chicken cooked with vegetables, herbs or spices produced mucolytic, immuno-modulatory and anti-inflammatory effects. The pharmacological effects are attributed to cysteine in the chicken meat and phytochemicals in the ingredients.