HVAC1
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This document provides information on the HVAC system of Platinum Pharmaceuticals including: - Specialized HVAC terms used in the system design. - Descriptions of 16 air handling units serving different production areas. - Filtration specifications for different areas based on ISO class requirements. - Key parameters to monitor for HVAC system performance such as air flow, temperature, humidity and microbial testing.
HVAC1
- 1. HVACsystem of PLATINUM PHARMACEUTICALS (PVT) LTD By Engr. M. Arsalan Mustafa B.E. (Industrial Engineer & Management) MBA (Supply Chain Management) 4/21/2015 1Prepared By: Engineering Department
- 2. 4/21/2015 2 HVAC (Heating, Ventilation and Air Conditioning) is a major sub-discipline of Mechanical Engineering. The goal of HVAC design is to balance indoor environmental comfort with other factor such as installation cost, ease of maintenance and energy efficiency. The discipline of HVAC includes a large number of specialized terms, some of which are listed in the next slide. Prepared By: Engineering Department HVAC
- 3. 4/21/2015 3 SPECIALIZED TERMS Operation & Control Units Chiller Cooling towers Condenser Water Circulation Pumps (Chill water & Condenser Water) Piping network Air Handling Units Supply / Return ducting Network Supply / Return Air Diffusers Filtration system Coil Air Conditioner (Quality Control LAB) Constant Air Volume Actuator / Motorize Valve Damper Dehumidifiers Prepared By: Engineering Department
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- 9. 4/21/2015 9 PRE FILTER G4 PRE FILTER 65% (washable at fresh air intake and exhaust) BAG FILTER 85 & 95% (85% on both supply and return and 95% on supply) HEPA FILTRATION 99.995% (HEPA filter integrity test) PROD. AREA DUST COLLECTOR (CLOTH FILTER) Prepared By: Engineering Department
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- 11. 4/21/2015 11 Air Flow in Cubic Feet per Minute (CFM) Test CFM as pre defined supply / Return Air defined limits. Humidity: As per product requirement but in general set the humidity (RH) limits in 45% - 55%. Temperature: As per designed specifications noted room temperature normal (230C +/-20C) / 70F - 74F Air Flow pattern: Test air flow and patterns negative / positive as per designed by consultant according to nature of activity. Pressure Differentials: Across the room/corridor test pressure differentials to minimize product contamination. Particular Count: Test the particle count in the area. Bag filters / HEPA filter integrity: Check the integrity of HEPA filter and monitor through pressure difference across the filter. Prepared By: Engineering Department
- 12. 4/21/2015 12 1. Granulation, Drying, Blending and Milling 2. Compression 3. Encapsulation 4. Dispensing 5. Solid Packaging Hall 6. Quality Control 7. Semi Solid Manufacturing and Filling 8. Liquid Filling with Bottle Blowing 9. Mouth wash Filling with Bottle Blowing 10. Liquid Packing Hall and Coding Area 11. Liquid Corridor 12. Semi Solid Packing Hall and In-Process Qrtn. 13. Blister Cubicle and Corridor, Klockner-1&2, CAM & UPS 14. Technical Office Area 15. Tableting Corridor 16. Dry syrup Area Prepared By: Engineering Department
- 13. 1. AHU # 01 Service Area: GRANULATION & DRYING Total Supply Air (CFM): 3450 Discharge Air Pressure: 750 PA Refrigeration Load: 12.4 RT Filtration: G4, F6 & F8 Chill Water Flow (max.): 30 US GPM 2. AHU# 02 Service Area: COMPRESSION Total Supply Air (CFM): 3450 Discharge Air Pressure: 750 PA Refrigeration Load: 13.1 RT Filtration: G4, F6 & F8 Chill Water Flow (max.): 31 US GPM 3. AHU # 03 Service Area: ENCAPSULATION Total Supply Air (CFM): 3480 Discharge Air Pressure: 700 PA Refrigeration Load: 13.8 RT Filtration: G4-F6-F8 Chill Water Flow (max.): 34 US GPM 4. AHU# 04 Service Area: DISPENSING Total Supply Air (CFM): 1420 Discharge Air Pressure: 625 PA Refrigeration Load: 9.6 RT Filtration: G4, F6 & F8 Chill Water Flow (max.): 23 US GPM Prepared By: Engineering Department4/21/2015 13
- 14. 5. AHU # 05 Service Area: SOLID PACKING HALL Total Supply Air (CFM): 2850 Discharge Air Pressure: 700 PA Refrigeration Load: 5.4 RT Filtration: G4-F6-F8 Chill Water Flow (max.): 32 GPM 6. AHU# 06 Service Area: OLD QC Total Supply Air (CFM): 3200 Discharge Air Pressure: 700 PA Permissible Air Flow: 500 FPM Filtration:F6-F8 Chill Water Flow (max.): 32 GPM 7. AHU # 07 Service Area: SEMI-SOLID MANUFACTURING AND FILLING Total Supply Air (CFM): 7150 Discharge Air Pressure: 1400 PA Refrigeration Load: 27.25 RT Filtration: G4-F6-F9-H13 Chill Water Flow (max.): 55 GPM 8. AHU# 08 Service Area: LIQUID FILLING WITH BOTTLE BLOWING Total Supply Air (CFM): 2420 Discharge Air Pressure: 1400 PA Refrigeration Load: 9.42 RT Filtration: G4-F6-F9-H13 Chill Water Flow (max.): 16 GPM4/21/2015 14
- 15. 9. AHU # 09 Service Area: MOUTH WASH FILLING WITH BOTTLE BLOWING Total Supply Air (CFM): 1950 Discharge Air Pressure: 1400 PA Refrigeration Load: 6.31 RT Filtration: G4-F6-F9-H13 Chill Water Flow (max.): 15 GPM 10. AHU# 10 Service Area: LIQUID PACKING HALL & COADING Total Supply Air (CFM): 4270 Discharge Air Pressure: 975 PA Refrigeration Load: 24.42 RT Filtration: G4-F6-F9 Chill Water Flow (max.): 49 GPM 11.AHU # 11 Service Area: LIQUID CORRIDOR Total Supply Air (CFM): 2650 Discharge Air Pressure: 975 PA Refrigeration Load: 16.42 RT Filtration: G4-F6-F9 Chill Water Flow (max.): 33 GPM 12. AHU# 12 Service Area: SEMI-SOLID PACKING HALL AND IN PROCESS QRTN. Total Supply Air (CFM): 3820 Discharge Air Pressure: 1575 PA Refrigeration Load: 10.36 RT Filtration: G4-F6-F9 Chill Water Flow (max.): 21 GPM 4/21/2015 15
- 16. 13. AHU # 13 Service Area: BLISTER, KLOCKNER 1,2, CAM BLISTER Total Supply Air (CFM): 5070 Discharge Air Pressure: 1300 PA Refrigeration Load: 20.5 RT Filtration: G4-F6-F9-H13 Chill Water Flow (max.): 43 GPM 14. AHU# 14 Service Area: TECH. OFFICE AREA Total Supply Air (CFM): 3450 Discharge Air Pressure: 200PA Refrigeration Load: 6.8 RT Filtration: F6-F8 Chill Water Flow (max.): 14.20 GPM 15. AHU # 15 Service Area: TABLETING CORRIDOR Total Supply Air (CFM): 3200 Discharge Air Pressure: 200 PA Refrigeration Load: 20.5 RT Filtration: F6-F8 Chill Water Flow (max.): 16.40 GPM 16. AHU# 16 Service Area: POWDER FILLING Total Supply Air (CFM): 2850 Discharge Air Pressure: 150 PA Refrigeration Load: 20.5 RT Filtration: G4-F6-F8-H13 Chill Water Flow (max.): 13.10 GPM Prepared By: Engineering Department4/21/2015 16
- 17. 4/21/2015 17 05 NOS AHUS (CEPH) & SINGLE CENTRAL DEHUMIDIFIER 1. Corridor, Conventional Coating Pan & Quality Control AHU # 01 2. Supervisor Room, Corridor, Compression, Encapsulation, Milling, Blending, Granulation & In-Process Qrtn. AHU# 02 3. Packaging Hall , Corridor & Qrtn. AHU # 03 4. Raw Material store & Dispensing. AHU# 04 5. Dry Syrup, Blister and Bottle Blowing. AHU # 05 Prepared By: Engineering Department
- 18. 1. AHU # 01 Service Area: In-Process Qrtn, Control Room, Coating & Passage. Total Supply Air (CFM): 2030 Discharge Air Pressure: 1650 PA Refrigeration Load: 12.25 RT Filtration: G4-F6-F8-H13 Chill Water Flow (max.): 24 US GPM 2. AHU# 02 Service Area: Milling, Granulation, Supervisor Room, Corridor, Compression, Encapsulation, Blending, & In-Process Qrtn. Total Supply Air (CFM): 10430 Discharge Air Pressure: 1650 PA Refrigeration Load: 33.75 RT Filtration: G4-F6-F8-H13 Chill Water Flow (max.): 68 US GPM 3. AHU # 03 Service Area: Packaging Hall , Corridor & Qrtn. Total Supply Air (CFM): 3350 Discharge Air Pressure: 1000 PA Refrigeration Load: 13.58 RT Filtration: G4-F6-F8-H13 Chill Water Flow (max.): 27 US GPM 4. AHU# 04 Service Area: Raw Material Store & Dispensing Total Supply Air (CFM): 1190 Discharge Air Pressure: 1650 PA Refrigeration Load: 3.8 RT Filtration: G4-F6-F8-H13 Chill Water Flow (max.): 08 US GPM Prepared By: Engineering Department4/21/2015 18
- 19. 5. AHU # 05 Service Area: Dry Syrup, Blister and Bottle Blowing Total Supply Air (CFM): 3830 Discharge Air Pressure: 1650 PA Refrigeration Load: 12.4 RT Filtration: G4-F6-F8-H13 Chill Water Flow (max.): 25 US GPM Prepared By: Engineering Department4/21/2015 19
- 20. 1. Blister AHU # 01 2. Compression & Encapsulation AHU# 04 3. Corridor AHU # 05 4. Granulation, Drying & Blending AHU# 06 5. Finished Goods store AHU # 07 6. Packing Hall & Corridor AHU # 09 7. Physician sample Store AHU# 10 4/21/2015 20 7 NOS AHUS (HARMONE) Prepared By: Engineering Department
- 21. 1. AHU # 01 Service Area: BLISTER Total Supply Air (CFM): 2850 Discharge Air Pressure: 150 PA Refrigeration Load: 4.3 RT Filtration: G4, F6 & F8 Chill Water Flow (max.): 13.10 GPM 2. AHU# 04 Service Area: COMPRESSION & ENCAPSULATION Total Supply Air (CFM): 3350 Discharge Air Pressure: 200 PA Refrigeration Load: 6.8 RT Filtration: G4, F6 & F8 Chill Water Flow (max.): 4.70 GPM 3. AHU # 05 Service Area: CORRIDOR Total Supply Air (CFM): 1400 Discharge Air Pressure: 1250PA Refrigeration Load: 2.5 RT Filtration: G4-F6-F8 Chill Water Flow (max.): 6 GPM 4. AHU# 06 Service Area: GRANULATION, DRYING & BLENDING Total Supply Air (CFM): 4100 Discharge Air Pressure: 200 PA Refrigeration Load: 10 RT Filtration: G4, F6 & F8 Chill Water Flow (max.): 24 GPM 4/21/2015 21
- 22. 6. AHU # 09 Service Area: PACKING HALL & CORRIDOR Total Supply Air (CFM): 5700 Discharge Air Pressure: 200 PA Refrigeration Load: 10.9 RT Filtration: G4-F6-F8 Chill Water Flow (max.): 26.20 GPM 7. AHU# 10 Service Area: PHYSCIAN SAMPLE Total Supply Air (CFM): 2850 Discharge Air Pressure: 150 PA Refrigeration Load: 5.5 RT Filtration: G4-F6-F8 Chill Water Flow (max.): 13 GPM 5. AHU # 07 Service Area: FINISHED GOOD STORE Total Supply Air (CFM): 7200 Discharge Air Pressure: 200 PA Refrigeration Load: 11.5 RT Filtration: G4-F6-F8 Chill Water Flow (max.): 30 GPM 4/21/2015 22
- 23. 4/21/2015 23 ISO Class S.No Area Class 1 Solid Manufacturing 100,000 2 Liquid Manufacturing 10,000 3 Solid Packing 100,000 4 Liquid Packing 10,000 5 Raw Material Store 100,000 6 Dispensing 100,000 7 Buffer 100,000 8 Dry Syrup Filling & Packing 10,000 9 Semi Solid Manufacturing 10,000 10 Semi Solid Packing 10,000 Prepared By: Engineering Department
- 24. 4/21/2015 24 In-coming / Return Air Air Changes of the area Direction of flow / pressure differentials Temperature Humidity Microbial contamination Testing Prepared By: Engineering Department
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- 27. OPERATION PARAMETER UNITED STATES EU COMMUNITY NON- STERILIZED PRODUCT OR CONTAINER (CONTROLLED AREA) AIR FLOW RATE Minimum 20 air changes/hr Higher than 20 air changes / hr. 4/21/2015 27Prepared By: Engineering Department
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- 29. 4/21/2015 29 Air Velocity Meter Pressure Differential Meter Physcrometer RPM Meter Prepared By: Engineering Department
- 30. 4/21/2015 30 On the Behalf of Technical Team Prepared By: Engineering Department