This document discusses essential hypertension and drug therapy for lowering blood pressure. It notes that thiazide diuretics are first-choice drugs for treating hypertension by excreting sodium and water from the body to initially lower blood pressure through vasodilation over the long term. While single drugs may not control blood pressure due to compensatory mechanisms, thiazides remain an important first-line treatment option for essential hypertension.
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39. Thiazides-
Like other diuretics they also excrete Na+ &
water which lowers blood pressure initially
Long term antihypertensive action is due to
vasodilation
40. DRUG THERAPY
Thiazides - first choice drugs in HTN unless
contra-indicated
BP may not be controlled by single drug due
to activation of compensatory mechanism
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