This document provides information on several immunologic disorders:
- Lyme disease, which is caused by a bacterial infection from an infected tick bite and can cause symptoms from a target rash to joint and neurological problems over time.
- Myasthenia gravis, an autoimmune disease that causes muscle weakness and fatigue and can be tested for using a Tensilon test.
- Guillain-Barr└ syndrome, an acute immune-mediated polyneuropathy where the immune system attacks the peripheral nerve myelin, causing weakness that typically starts in the legs and can involve respiratory muscles. Diagnosis involves lumbar puncture and electromyography.
4. LYME DISEASE
?Lyme disease is a bacterial infection person get from
the bite of an infected tick The first symptom is usually a
red rash, which may look like a bull's eye
6. Early disseminated
infection
days to weeks
?migrating pain in muscles,
joints, and tendons
?heart palpitations
?dizziness
?facial palsy
?meningitis
?Mild encephalitis
?memory loss
?sleep disturbances
?mood changes
Early localized
infection
3 C 30 days
?Target Lesion
?Rash is
generally
painless.
? flu-like symptoms
?Headache
?muscle soreness
?Fever
?malaise
Late disseminated
infection
After several months
the brain, nerves, eyes,
joints and heart.
?Profound fatigue
?Depression
? Fibromyalgia
?encephalomyelitis
Cognitive impairment,
?Facial palsy,
?Schizophrenia
?Bipolar disorder
?Panic attacks
?Anxiety delusions,
? Painful joints
16. Cause of Myasthenia Gravis
* Unknown
* One of many ^autoimmune diseases ̄
* A basic problem with the immune system - parts of it are overactive
* Individuals with MG and their family members more likely to have
one of these other autoimmune diseases
22. GBS
? acute immune-mediated
polyneuropathies
? Peripheral nerve myelin is target of an immune
attack
? Starts at level of nerve root=conduction blocks &
muscle weakness
? Eventually get widespread patchy demyelination=
increased paralysis
23. Risk Factor
? More in men
? Recent vaccination
? Recent GIT or Respiratory system infection
? Recent surgery
24. Clinical Features:
?Progressive, fairly symmetric muscle
weakness
-typically starts in proximal legs
-10% will 1st develop weakness in face or arms
? Diminished DTR
? severe resp muscle weakness in 10-
30% pts
? oropharyngeal weakness in ~ 50%
25. Diagnosis:
elevated CSF protein w/ normal WBC
(80-90% pts)
? Electromyography (EMG) helps
confirm diagnosis = prolonged or
absent F waves