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INCIDENCE OF HELICOBACTER PYLORI IN PATIENTS WITH GASTRITIS

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Sarvoday Sinha

This document summarizes a study that examined the incidence of Helicobacter pylori in 50 patients with gastritis. Endoscopy and CLO testing found H. pylori present in 21 of 50 patients (42% incidence). A chi-square test showed a significant association between H. pylori and gastritis (p=0.017). The study concludes that H. pylori is significantly associated with gastritis and that anti-H. pylori treatment is more effective than proton pump inhibitors alone.

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INCIDENCE OF Helicobacter pylori IN PATIENTS WITH GASTRITISGUIDED BY:-Dr. Girish D. BakhshiASSOCIATE PROFESSOR DEPARTMENT OF SURGERY,GRANT MEDICAL COLLEGEPRESENTATION BY:-Sarvodayai SinhaIII/III MBBSGRANT MEDICAL COLLEGE
Is Gastritis becoming a common problem? Ref: National Institute of Diabetes and Digestive and Kidney Diseases
HISTORY
HISTORY J. Robin Warren and Barry Marshall(1982)discovered the association of Helicobacter pylori with gastritis and peptic ulcers.Ref: Marshall & Barry, ＾Helicobacter Pioneers￣
INCIDENCE OF HELICOBACTER PYLORI IN PATIENTS WITH GASTRITIS
MATERIALS & METHODSSample size = 50 patients.Total duration = 3 months. Approved by Institutional Ethics Committee (IEC).
INCLUSION CRITERIAHeartburn Water brashNausea/Vomiting
EXCLUSION CRITERIAPatients < 18 years of age.Pregnant women.Patients on NSAIDs.Patients on AKT.
EXCLUSION CRITERIASystemic illness like DM/IHD/HTN.Complications of ulcer.Previous acid lowering surgery/oesophagus surgery.
MATERIALS & METHODSEndoscopy performed after the prior consent.Extraction of gastric antral tissue.CLO(Campylobacter Like Organisms) test performed.
MATERIALS & METHODSDuration of observation : 48 hours.Comparison with the histopathological report.Patients administered with drugs.
STATISTICAL ANALYSIS PLANChi square test with Yates¨ correction.
OBSERVATIONS & RESULTS21/50 patients positive for the H.pylori test; incidence = 42%Colour of the PYLOTEST kit: yellowpinkH.pylori present
NEGATIVEPOSITIVE
INCIDENCE OF HELICOBACTER PYLORI IN PATIENTS WITH GASTRITIS
INCIDENCE OF HELICOBACTER PYLORI IN PATIENTS WITH GASTRITIS
SEX DISTRIBUTION
APPROACH TO GASTRITIS PATIENTS
Anti H.pylori regimenClarithromycin 500 mgPantoprazole 40 mgAmoxicillin 750 mgTwice daily (morning & evening) for 14 days
INCIDENCE OF HELICOBACTER PYLORI IN PATIENTS WITH GASTRITIS
CHI SQUARE TEST RESULTUsing the formula of Chi square test with Yates¨ correction :- where O = observed value E = expected value df = degree of freedomRef: Yates F (1934);"Contingency table involving small numbers and the χ2 test", Journal of the Royal Statistical Society
CHI SQUARE TEST RESULTAt p=0.05 (Fischer¨s table) ; On calculation;Corresponding p value = 0.017 (<0.05)
CONCLUSIONSignificant association of Helicobacter pylori with gastritis. Consistency of CLO test (pylotest)being consistent with histopathologic studies.Anti-H.pylori regimen being more promising than the proton-pump inhibitors alone.
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INCIDENCE OF HELICOBACTER PYLORI IN PATIENTS WITH GASTRITIS

  • 1. INCIDENCE OF Helicobacter pylori IN PATIENTS WITH GASTRITISGUIDED BY:-Dr. Girish D. BakhshiASSOCIATE PROFESSOR DEPARTMENT OF SURGERY,GRANT MEDICAL COLLEGEPRESENTATION BY:-Sarvodayai SinhaIII/III MBBSGRANT MEDICAL COLLEGE
  • 2. Is Gastritis becoming a common problem? Ref: National Institute of Diabetes and Digestive and Kidney Diseases
  • 4. HISTORY J. Robin Warren and Barry Marshall(1982)discovered the association of Helicobacter pylori with gastritis and peptic ulcers.Ref: Marshall & Barry, ＾Helicobacter Pioneers￣
  • 6. MATERIALS & METHODSSample size = 50 patients.Total duration = 3 months. Approved by Institutional Ethics Committee (IEC).
  • 7. INCLUSION CRITERIAHeartburn Water brashNausea/Vomiting
  • 8. EXCLUSION CRITERIAPatients < 18 years of age.Pregnant women.Patients on NSAIDs.Patients on AKT.
  • 9. EXCLUSION CRITERIASystemic illness like DM/IHD/HTN.Complications of ulcer.Previous acid lowering surgery/oesophagus surgery.
  • 10. MATERIALS & METHODSEndoscopy performed after the prior consent.Extraction of gastric antral tissue.CLO(Campylobacter Like Organisms) test performed.
  • 11. MATERIALS & METHODSDuration of observation : 48 hours.Comparison with the histopathological report.Patients administered with drugs.
  • 12. STATISTICAL ANALYSIS PLANChi square test with Yates¨ correction.
  • 13. OBSERVATIONS & RESULTS21/50 patients positive for the H.pylori test; incidence = 42%Colour of the PYLOTEST kit: yellowpinkH.pylori present
  • 19. Anti H.pylori regimenClarithromycin 500 mgPantoprazole 40 mgAmoxicillin 750 mgTwice daily (morning & evening) for 14 days
  • 21. CHI SQUARE TEST RESULTUsing the formula of Chi square test with Yates¨ correction :- where O = observed value E = expected value df = degree of freedomRef: Yates F (1934);"Contingency table involving small numbers and the χ2 test", Journal of the Royal Statistical Society
  • 22. CHI SQUARE TEST RESULTAt p=0.05 (Fischer¨s table) ; On calculation;Corresponding p value = 0.017 (<0.05)
  • 23. CONCLUSIONSignificant association of Helicobacter pylori with gastritis. Consistency of CLO test (pylotest)being consistent with histopathologic studies.Anti-H.pylori regimen being more promising than the proton-pump inhibitors alone.