2. Dr.
Shivankan
Kakkar,
MD
2
Introduction to Insect Repellents
Definition: Substances applied to skin, clothing, or
surfaces to deter insects.
Primary Use: Protection against mosquitoes and other
pests (flies, fleas, cockroaches).
Importance: Reduces risk of mosquito-borne diseases
like malaria and dengue.
3. Dr.
Shivankan
Kakkar,
MD
3
Mechanism of Action
Host Attraction: Mosquitoes use smell to locate hosts
(human body odour & CO ).
Repellent Action: Interact with insect odorant
receptors to deter mosquitoes.
Efficacy Assays: Host-attraction inhibition and other
methods to measure effectiveness.
4. Dr.
Shivankan
Kakkar,
MD
4
Common Synthetic Repellents
1. DEET (N,N-diethyl-m-toluamide)
o Widely used for over 70 years.
o Effective for 1-6 hours.
o Absorbed through skin; may cause irritation.
2. Picaridin
o Synthetic equivalent of piperine.
o Offers 6-12 hours of protection; less irritation compared to DEET.
3. Pyrethroids (Prallethrin, Transfluthrin)
o Fast-acting, effective in vapor form.
o Potential side effects include nausea and dizziness.
5. Dr.
Shivankan
Kakkar,
MD
5
Natural Repellents
Essential Oils: Generally less effective and shorter lasting.
Common Types:
o Citronella Oil: Effective for ~2 hours.
o Lemon-Eucalyptus Oil: Active against mosquitoes.
o Neem Oil: Effective for up to 12 hours; has a strong odor.
Safety: Typically considered nontoxic for children and pregnant
women.
6. Dr.
Shivankan
Kakkar,
MD
6
Safety & Precautions
Side Effects of DEET:
o Skin irritation, insomnia, mood disturbances.
o Neurotoxicity and seizures in rare cases.
Usage Tips:
o Avoid contact with eyes/mucous membranes.
o Reapply as needed, but avoid overuse.