2. 2
By the end of this lecture you will be able to:
?Describe the process of infectious diseases transmission (Chain
of infection)
?List the types of RESERVOIR of infectious diseases of human
?Define a CARRIER and list its types.
?Define ZOONOSES and list examples.
?Identify the different MODE OF TRANSMISSION of the organisms
from the reservoir to the susceptible host.
September 22, 2014 2
OBJECTIVES OF THE LECTURE
4. 4
A process that begins when an agent leaves its
reservoir through a portal of exit, and is
conveyed by some mode of transmission, then
enters through an appropriate portal of entry to
infect a susceptible host.
Cycle of infection
September 22, 2014
5. September 22, 2014 5
The essential elements for Communicable Disease
Transmission:
1. Presence of microbiological agent.
2. Presence of reservoir.
3. Portal of exit.
4. Mode of transmission.
5. Portal of entry (inlet).
6. Presence of susceptible host.
Factors affecting perpetuation/spread of
Communicable diseases
6. September 22, 2014 6
Agent
? Microorganisms are responsible for disease production
(viruses, bacteria, protozoa, parasites, fungi,..
? Agent characteristics that affect disease transmission:
C Infectivity
C Pathogenicity
C Virulence
C Antigenicity
C Toxicity, dose of inoculums, resistance strains,´´
7. September 22, 2014 7
The ability of an agent to invade and multiply (produce infection) in
The ability of an agent to invade and multiply (produce infection) in
a susceptible host.
a susceptible host.
How to measure
How to measure (
(Infectivity);
Infectivity); ease & spread of infection?
ease & spread of infection?
Secondary Attack Rate
Secondary Attack Rate
The proportion of exposed susceptible persons who become
The proportion of exposed susceptible persons who become
infected.
infected.
Examples: High infectivity: Measles, Chickenpox
Examples: High infectivity: Measles, Chickenpox
Low infectivity: Leprosy
Low infectivity: Leprosy
100
sec
x
es
susceptibl
of
Number
cases
ondary
of
Number
rate
attack
Secondary ?
Infectivity
8. September 22, 2014 8
Is the ability of the organisms to produce specific clinical reaction after
infection
It refers to the proportion of infected persons who develop clinical
disease.
Examples:
? High pathogenicity: Measles, Chickenpox (Class B)
? Low pathogenicity: Polio, Tuberculosis, Hepatitis A, Meningitis,
AIDS (Class A)
It can be measured by:
cases
l
Subclinica
cases
Clinical
Ratio of clinical to sub-clinical case
Ratio of clinical to sub-clinical case=
=
Pathogenicity
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The ability of an infectious agent to cause severe disease, measured as
the proportion of persons with the disease who become severely
ill or die.
Examples: Rabies, Hemorrhagic fevers caused by Ebola and Murberg
viruses. (Class C)
100
disease
that
of
cases
of
number
Total
disease
a
from
deaths
of
number
Total
rate
fatality
Case x
?
Virulence is measured by: Case fatality rate
Virulence
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The ability of the organism to produce specific immunity
(antibodies or antitoxin).
It can be measured by:
Second attack frequency:
Second attack frequency:
Second attacks are rare: measles, mumps and chickenpox.
measles, mumps and chickenpox.
Re-infection occurs frequently: common cold, syphilis and
common cold, syphilis and
gonorrhea.
gonorrhea.
Antigenicity (Immunogenicity)
11. 2. Reservoir of infection
Types of Reservoir
Human
reservoir
Animal
reservoir
Non-living
reservoir
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The reservoir of an agent is the habitat in which an
infectious agent normally lives, grows, and multiplies.
12. Human reservoirs
Two types of human reservoirs exist:
? Case
? Carrier: A person that harbors the infectious agent for a
disease and can transmit it to others, but does not
demonstrate signs of the disease.
C Temporary OR Chronic (such as Salmonella typhi,´
C Carriers have no symptoms, not diagnosed, so can infect
others, causing infection control difficult.
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13. September 22, 2014 13
Zoonoses: An infection or infectious disease transmissible under
natural conditions from vertebrate animals to humans.
More than 100 Zoonotic diseases such as Brucellosis (sheep, goats
and pigs), Bovine tuberculosis (cattle), Rabies (bats, dogs, and other
mammals).
Environmental reservoirs: For example: Soil may harbor spores that
causes tetanus and anthrax. Pools of water are the primary
reservoir of Legionnaires¨ bacillus.
Reservoirs
14. 3. Portal of exit
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Portal of exit is the path by which an agent leaves the
source host. E.g.
Examples:
? Urinary tract
? Intestinal tract
? Respiratory tract
? Skin and mucous membrane
? Blood
16. Direct Transmission
Direct modes: reservoir & susceptible host are physically
present together resulting in immediate transfer of
infectious agent:
1- Direct contact: e.g. Sexually Transmitted Infections
2- Droplet infection: e.g. Sneezing leading to ARI
3-Contact with soil: e.g. Tetanus, hookworm larvae
4-Inoculation into skin or mucosa: e.g. Rabies, Hep B
5- Trans-placental: Mother to her fetus, e.g. HIV
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17. Indirect transmission
1- Vehicle-borne: The agent may multiply in the vehicle before
transmission. FOOD (e.g. Hep A), WATER (e.g. Cholera),
MILK (e.g. TB), BLOOD (e.g Hep B)
2- Vector-borne: arthropod or other living carrier e.g. Flies
carrying Shigella, and Mosquito propagating malaria
parasites
3- Airborne: e.g TB transmitted indirectly through airborne
transmission, than directly through direct droplet spread.
Legionnaires¨ disease and fungal spores also spread through
airborne transmission.
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18. 4- Fomite-borne: e.g. clothes, cups, door handles, surgical
dressings and instruments. Disease examples Hep A,
Influenza, Eye infections
5- Unclean hands & fingers: causing, e.g., typhoid, staph. &
strept. infection, hepatitis A
Indirect transmission
September 22, 2014 18
19. 5. Portal of entry
? An agent enters a susceptible host through a portal
of entry. The portal of entry must provide access to
tissues in which the agent can multiply or a toxin can
act.
? Often, organisms use the same portal to enter a new
host as that they use to exit the source host.
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20. 6. Susceptible host
Host that doesn't have resistance against a particular pathogenic
agent is liable to contract the disease when exposed to such agent
(i.e. susceptible).
Resistance: is total body mechanisms which interpose barriers to
progression of invasion& or multiplication of infectious agent.
Susceptibility depends on:
? Genetic factors
? Malnutrition, Alcoholism, Disease, Therapy which impairs the
immune response (e.g. cortisone, cytotoxic drugs, ...)
? Acquired Immunity (natural/Artificial)
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21. September 22, 2014 21
o Skin, Mucous membranes, Gastric acidity, Cilia in the
respiratory tract, Cough reflex
o Nonspecific immune response; phagocytes
o Specific immune response. i.e protective antibodies
that are directed against a specific agent.
Body defense mechanism against infection
22. Herd immunity
It is the state of immunity of a group or a community.
Also it is;
＾The resistance of a group to invasion and spread of an infectious
agent, based on the immunity of a high proportion of individual
members of the group￣.
September 22, 2014 22
23. Factors Affecting Herd Immunity:
? The extent of coverage of the immunization program.
? The degree of resistance to infection afforded by the
vaccine.
? Duration and degree of infectivity of the organism.
? Past experience with different infections.
? Overcrowding and environmental sanitation.
September 22, 2014 23
24. September 22, 2014 24
Reference books
? Principles of Epidemiology in Public Health Practice. Third
Edition. An Introduction to Applied Epidemiology and
Biostatistics. Centers for Disease Control and Prevention
(CDC)
? Porta M. A dictionary of epidemiology. 5th
Edition. Oxford,
New York: Oxford University Press, 2008.
? Gordis L. Epidemiology. 4th
edition. Philadelphia,
Pennsylvania: Elsevier Science, 2008
? Beaglehole R, Bonita R, Kjellstrom T. Basic epidemiology.
2nd
edition. Geneva: World Health Organization, 2006
