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 Highlights ASBMR 2021  San Diego
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Prof. Dr. Joop van den Bergh
 Highlights ASBMR 2021  San Diego
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Prof. Dr. Joop van den Bergh
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Prof. Dr. Joop van den Bergh
Relations that could be relevant for the meeting Company name

 Research funds


 Speaker board / consultancy


 Stakeholder


 Stock or other

 Amgen, UCB, Eli Lilly


 Amgen, UCB


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Disclosures
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Fracture risk
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Treatment - BMD
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Total Hip BMD

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Total Hip BMD

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Spine
Total Hip
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Treatment  drug holiday
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ASBMR/ECTS Clinical Debate: Intermittent Drug Holidays Are
Mandatory for Long Term Bisphosphonate Treatment of
Osteoporosis?
ASBMR  in support
ECTS - against
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Prof. Dr. Joop van den Bergh
ASBMR/ECTS Clinical Debate: Intermittent Drug Holidays Are
Mandatory for Long Term Bisphosphonate Treatment of
Osteoporosis?
ASBMR  in support
	
	
	
	
Winner: ECTS - against
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Mandatory = obligatory, binding
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Treatment: new and real-world data
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A Six-month Phase 2 Study of Oral PTH in Postmenopausal Women with Low
Bone Mass  6 Month Bone Mineral Density (BMD) results

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Teriparatide / Abaloparatide
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Treatment  safety
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ONJ
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AFF
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 The cohort consists of 60 AFF patients (almost all treated with BPs)


 The AFF patients were classified into three groups:


 group 1, clinically suspected of a monogenic bone disorder and genetically
confirmed with a pathogenic variant through NGS gene panel testing as routine
medical care


 group 2, clinically suspected of a monogenic bone disorder without genetic
confirmation


 group 3, no clinical suspicion of monogenic bone disorders


 Whole exome sequencing (WES) was performed in all patients and
variants were classified based on the American College of Medical
Genetics and Genomics (ACMG) classification guideline
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Vitamin D
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Artificial Intelligence
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Scoliosis and spine shape
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