The document appears to be a presentation on highlights from the ASBMR 2021 conference in San Diego. It discusses several topics that were covered at the conference, including fracture risk assessment, the effects of various osteoporosis treatments on bone mineral density, safety issues like osteonecrosis of the jaw and atypical femoral fractures, the role of vitamin D, and applications of artificial intelligence. The entire document is copyrighted by Prof. Dr. Joop van den Bergh.
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IWO Meeting 17 November 2021 - Prof. Dr. Joop van den Bergh
1. Highlights ASBMR 2021 San Diego
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Prof. Dr. Joop van den Bergh
2. Highlights ASBMR 2021 San Diego
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Prof. Dr. Joop van den Bergh
4. Relations that could be relevant for the meeting Company name
Research funds
Speaker board / consultancy
Stakeholder
Stock or other
Amgen, UCB, Eli Lilly
Amgen, UCB
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Disclosures
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Prof. Dr. Joop van den Bergh
31. Treatment drug holiday
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Prof. Dr. Joop van den Bergh
32. ASBMR/ECTS Clinical Debate: Intermittent Drug Holidays Are
Mandatory for Long Term Bisphosphonate Treatment of
Osteoporosis?
ASBMR in support
ECTS - against
Copyright
Prof. Dr. Joop van den Bergh
33. ASBMR/ECTS Clinical Debate: Intermittent Drug Holidays Are
Mandatory for Long Term Bisphosphonate Treatment of
Osteoporosis?
ASBMR in support
Winner: ECTS - against
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Prof. Dr. Joop van den Bergh
37. Treatment: new and real-world data
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Prof. Dr. Joop van den Bergh
38. A Six-month Phase 2 Study of Oral PTH in Postmenopausal Women with Low
Bone Mass 6 Month Bone Mineral Density (BMD) results
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Prof. Dr. Joop van den Bergh
58. The cohort consists of 60 AFF patients (almost all treated with BPs)
The AFF patients were classified into three groups:
group 1, clinically suspected of a monogenic bone disorder and genetically
confirmed with a pathogenic variant through NGS gene panel testing as routine
medical care
group 2, clinically suspected of a monogenic bone disorder without genetic
confirmation
group 3, no clinical suspicion of monogenic bone disorders
Whole exome sequencing (WES) was performed in all patients and
variants were classified based on the American College of Medical
Genetics and Genomics (ACMG) classification guideline
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Prof. Dr. Joop van den Bergh