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In Drug Metabolism is the process of converting a drug into product or inert substances after or before reaching at the site of action.
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1.Metabolic transformation ( biotransformation ) and
2.Conjugation
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Reaction type of Phase-I:
1.Oxidation
2.Reduction
3.Hydrolysis
Most drugs are metabolised ,atleast to some extent , by both phases of metabolism.
Example: Metabolism of Aspirin
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In Phase-II the metabolites formed in Phase-II are converted to more polar and water soluble product by attaching polar and ionisable moiety such as
1.Glucuronic acid
2.Glycine
3.Glutamine
4.Glutathione conjugation
5.Acetylation
6.Methylation
7.Sulfate conjugation
8.Nucleoside and Nucleotide formation
9.Amino Acid Conjugation
10.Fatty Acid and Cholesterol Conjugation
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Drug design considers metabolism to optimize pharmaco kinects ( ADME: Absorption , Distribution , Metabolism , Excretion )
Cytochrome CYP450 enzyme in Drug Metabolism is vital in drug design to enhance efficacy , reduce toxicity and improve bioavailability.
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Cytochrome P-450 activity in various organs like Liver,Lung ,Kidney , Intestine,Placenta
Adrenal and Skin and they shows the relative activity with repect to their organs in the process of drug metabolism.
Most important CYP450 enzymes are CYP1A2 , CYP2C9 , CYP2E1
,etc...
Toxic Effects of Drug Metabolism
Toxicity: Accumulation of Excess of medications in the Blood Stream.
Ariens (1948) and Mitchell and Horning (1984) deal with this topic.
Some examples of Metabolism-Linked Toxicity are
1.Acetaminophen (paracetmol)
2.Isoniazid ( TB drug)
3.Chloroform
4.Dapsone
5.Diazepam
6.Salicylate
7.Halothane (Anesthetic)
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Technology
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Hispanics may have a built-in defense against the isolation technology breeds, owing to their large, multigenerational households, strong social support systems, and tendency to use social media to stay connected with relatives abroad.
Age and Gender
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As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).AI Trends in Creative Operations 2024 by Artwork Flow.pdf
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Metabolism plays an important role in elimination of drugs and foreign substance from the body.
The metabolism of any drug is generally characterised by two phases of reaction
1.Metabolic transformation ( biotransformation ) and
2.Conjugation
The Principal site of drug metabolism is the liver, but the kidney, lungs, and GIT also are important metabolic sites.
The enzymatic bio transformations of drugs is known as Drug Metabolism. Because many drugs have structures similar to those of endogenous compounds , drugs may get metabolised by specific enzymes for the related natural substrates as well as by non-specific enzymes.
Reaction type of Phase-I:
1.Oxidation
2.Reduction
3.Hydrolysis
Most drugs are metabolised ,atleast to some extent , by both phases of metabolism.
Example: Metabolism of Aspirin
Acetyl Salicylic acid undergoes hydrolysis to salicylic acid ( metabolic transformation ), which is then conjugated with glycine to form Salicyluric acid ( Conjugation ).
In Phase-II the metabolites formed in Phase-II are converted to more polar and water soluble product by attaching polar and ionisable moiety such as
1.Glucuronic acid
2.Glycine
3.Glutamine
4.Glutathione conjugation
5.Acetylation
6.Methylation
7.Sulfate conjugation
8.Nucleoside and Nucleotide formation
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Drug design considers metabolism to optimize pharmaco kinects ( ADME: Absorption , Distribution , Metabolism , Excretion )
Cytochrome CYP450 enzyme in Drug Metabolism is vital in drug design to enhance efficacy , reduce toxicity and improve bioavailability.
Cytochrome P450 enzymes (CYPs) are a superfamily of heme -containing proteins found from bacteria to human.
Cytochrome P-450 activity in various organs like Liver,Lung ,Kidney , Intestine,Placenta
Adrenal and Skin and they shows the relative activity with repect to their organs in the process of drug metabolism.
Most important CYP450 enzymes are CYP1A2 , CYP2C9 , CYP2E1
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Toxic Effects of Drug Metabolism
Toxicity: Accumulation of Excess of medications in the Blood Stream.
Ariens (1948) and Mitchell and Horning (1984) deal with this topic.
Some examples of Metabolism-Linked Toxicity are
1.Acetaminophen (paracetmol)
2.Isoniazid ( TB drug)
3.Chloroform
4.Dapsone
5.Diazepam
6.Salicylate
7.Halothane (Anesthetic)
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To better understand how Americans are feeling and their attitudes towards mental health in general, ThinkNow conducted a nationally representative quantitative survey of 1,500 respondents and found some interesting differences among ethnic, age and gender groups.
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A report by thenetworkone and Kurio.
The contributing experts and agencies are (in an alphabetical order): Sylwia Rytel, Social Media Supervisor, 180heartbeats + JUNG v MATT (PL), Sharlene Jenner, Vice President - Director of Engagement Strategy, Abelson Taylor (USA), Alex Casanovas, Digital Director, Atrevia (ES), Dora Beilin, Senior Social Strategist, Barrett Hoffher (USA), Min Seo, Campaign Director, Brand New Agency (KR), Desh辿 M. Gully, Associate Strategist, Day One Agency (USA), Francesca Trevisan, Strategist, Different (IT), Trevor Crossman, CX and Digital Transformation Director; Olivia Hussey, Strategic Planner; Simi Srinarula, Social Media Manager, The Hallway (AUS), James Hebbert, Managing Director, Hylink (CN / UK), Mundy lvarez, Planning Director; Pedro Rojas, Social Media Manager; Pancho Gonz叩lez, CCO, Inbrax (CH), Oana Oprea, Head of Digital Planning, Jam Session Agency (RO), Amy Bottrill, Social Account Director, Launch (UK), Gaby Arriaga, Founder, Leonardo1452 (MX), Shantesh S Row, Creative Director, Liwa (UAE), Rajesh Mehta, Chief Strategy Officer; Dhruv Gaur, Digital Planning Lead; Leonie Mergulhao, Account Supervisor - Social Media & PR, Medulla (IN), Aurelija Plioplyt, Head of Digital & Social, Not Perfect (LI), Daiana Khaidargaliyeva, Account Manager, Osaka Labs (UK / USA), Stefanie Sohnchen, Vice President Digital, PIABO Communications (DE), Elisabeth Winiartati, Managing Consultant, Head of Global Integrated Communications; Lydia Aprina, Account Manager, Integrated Marketing and Communications; Nita Prabowo, Account Manager, Integrated Marketing and Communications; Okhi, Web Developer, PNTR Group (ID), Kei Obusan, Insights Director; Daffi Ranandi, Insights Manager, Radarr (SG), Gautam Reghunath, Co-founder & CEO, Talented (IN), Donagh Humphreys, Head of Social and Digital Innovation, THINKHOUSE (IRE), Sarah Yim, Strategy Director, Zulu Alpha Kilo (CA).Trends In Paid Search: Navigating The Digital Landscape In 2024
Trends In Paid Search: Navigating The Digital Landscape In 2024Search Engine Journal
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The search marketing landscape is evolving rapidly with new technologies, and professionals, like you, rely on innovative paid search strategies to meet changing demands.
Its important that youre ready to implement new strategies in 2024.
Check this out and learn the top trends in paid search advertising that are expected to gain traction, so you can drive higher ROI more efficiently in 2024.
Youll learn:
- The latest trends in AI and automation, and what this means for an evolving paid search ecosystem.
- New developments in privacy and data regulation.
- Emerging ad formats that are expected to make an impact next year.
Watch Sreekant Lanka from iQuanti and Irina Klein from OneMain Financial as they dive into the future of paid search and explore the trends, strategies, and technologies that will shape the search marketing landscape.
If youre looking to assess your paid search strategy and design an industry-aligned plan for 2024, then this webinar is for you.5 Public speaking tips from TED - Visualized summary
5 Public speaking tips from TED - Visualized summarySpeakerHub
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From their humble beginnings in 1984, TED has grown into the worlds most powerful amplifier for speakers and thought-leaders to share their ideas. They have over 2,400 filmed talks (not including the 30,000+ TEDx videos) freely available online, and have hosted over 17,500 events around the world.
With over one billion views in a year, its no wonder that so many speakers are looking to TED for ideas on how to share their message more effectively.
The article 5 Public-Speaking Tips TED Gives Its Speakers, by Carmine Gallo for Forbes, gives speakers five practical ways to connect with their audience, and effectively share their ideas on stage.
Whether you are gearing up to get on a TED stage yourself, or just want to master the skills that so many of their speakers possess, these tips and quotes from Chris Anderson, the TED Talks Curator, will encourage you to make the most impactful impression on your audience.
See the full article and more summaries like this on SpeakerHub here: https://speakerhub.com/blog/5-presentation-tips-ted-gives-its-speakers
See the original article on Forbes here:
http://www.forbes.com/forbes/welcome/?toURL=http://www.forbes.com/sites/carminegallo/2016/05/06/5-public-speaking-tips-ted-gives-its-speakers/&refURL=&referrer=#5c07a8221d9bChatGPT and the Future of Work - Clark Boyd 
ChatGPT and the Future of Work - Clark Boyd Clark Boyd
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Everyone is in agreement that ChatGPT (and other generative AI tools) will shape the future of work. Yet there is little consensus on exactly how, when, and to what extent this technology will change our world.
Businesses that extract maximum value from ChatGPT will use it as a collaborative tool for everything from brainstorming to technical maintenance.
For individuals, now is the time to pinpoint the skills the future professional will need to thrive in the AI age.
Check out this presentation to understand what ChatGPT is, how it will shape the future of work, and how you can prepare to take advantage. Getting into the tech field. what next 
Getting into the tech field. what next Tessa Mero
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The document provides career advice for getting into the tech field, including:
- Doing projects and internships in college to build a portfolio.
- Learning about different roles and technologies through industry research.
- Contributing to open source projects to build experience and network.
- Developing a personal brand through a website and social media presence.
- Networking through events, communities, and finding a mentor.
- Practicing interviews through mock interviews and whiteboarding coding questions.Google's Just Not That Into You: Understanding Core Updates & Search Intent
Google's Just Not That Into You: Understanding Core Updates & Search IntentLily Ray
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1. Core updates from Google periodically change how its algorithms assess and rank websites and pages. This can impact rankings through shifts in user intent, site quality issues being caught up to, world events influencing queries, and overhauls to search like the E-A-T framework.
2. There are many possible user intents beyond just transactional, navigational and informational. Identifying intent shifts is important during core updates. Sites may need to optimize for new intents through different content types and sections.
3. Responding effectively to core updates requires analyzing "before and after" data to understand changes, identifying new intents or page types, and ensuring content matches appropriate intents across video, images, knowledge graphs and more.How to have difficult conversations 
How to have difficult conversations Rajiv Jayarajah, MAppComm, ACC
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Stop putting off having difficult conversations. Seven practical tips to ensure your next difficult conversation go smoothly. Introduction to Data Science
Introduction to Data ScienceChristy Abraham Joy
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A brief introduction to DataScience with explaining of the concepts, algorithms, machine learning, supervised and unsupervised learning, clustering, statistics, data preprocessing, real-world applications etc.
It's part of a Data Science Corner Campaign where I will be discussing the fundamentals of DataScience, AIML, Statistics etc.Time Management & Productivity - Best Practices
Time Management & Productivity - Best PracticesVit Horky
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Here's my presentation on by proven best practices how to manage your work time effectively and how to improve your productivity. It includes practical tips and how to use tools such as Slack, Google Apps, Hubspot, Google Calendar, Gmail and others.The six step guide to practical project management
The six step guide to practical project managementMindGenius
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The six step guide to practical project management
If you think managing projects is too difficult, think again.
Weve stripped back project management processes to the
basics to make it quicker and easier, without sacrificing
the vital ingredients for success.
If youre looking for some real-world guidance, then The Six Step Guide to Practical Project Management will help.
Dr Andrew Makar, Tactical Project ManagementBeginners Guide to TikTok for Search - Rachel Pearson - We are Tilt __ Bright...
Beginners Guide to TikTok for Search - Rachel Pearson - We are Tilt __ Bright...RachelPearson36
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A presentation for absolute beginners who have never touched TikTok and may be a bit scared of it!Unlocking the Power of ChatGPT and AI in Testing - A Real-World Look, present...
Unlocking the Power of ChatGPT and AI in Testing - A Real-World Look, present...Applitools
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During this webinar, Anand Bagmar demonstrates how AI tools such as ChatGPT can be applied to various stages of the software development life cycle (SDLC) using an eCommerce application case study. Find the on-demand recording and more info at https://applitools.info/b59
Key takeaways:
Learn how to use ChatGPT to add AI power to your testing and test automation
Understand the limitations of the technology and where human expertise is crucial
Gain insight into different AI-based tools
Adopt AI-based tools to stay relevant and optimize work for developers and testers
* ChatGPT and OpenAI belong to OpenAI, L.L.C.12 Ways to Increase Your Influence at Work
12 Ways to Increase Your Influence at WorkGetSmarter
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To succeed in your career, you need a strategy for sending out ripples of influence. Here are 12 ways you can start doing just that. ChatGPT webinar slides
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The document discusses various AI tools from OpenAI like GPT-3 and DALL-E 2, as well as ChatGPT. It explores how search engines are using AI and things to consider around AI-generated content. Potential SEO uses of ChatGPT are also presented, such as generating content at scale, conducting topic research, and automating basic coding tasks. The document encourages further reading on using ChatGPT for SEO purposes.John allen
- 1. John allen
- 2. rocks